ESCRT articles within Nature Communications

Featured

  • Article
    | Open Access

    Completion of cell division requires severing both the microtubules and the plasma membrane that connects daughter cells. Here, the authors show that branched actin regulates ESCRT localization to promote the microtubule cut, which happens before membrane scission.

    • Tamara Advedissian
    • , Stéphane Frémont
    •  & Arnaud Echard
  • Article
    | Open Access

    Lack of CD8+ T-cell infiltration into solid tumors is associated with poor responsiveness to immune checkpoint therapy (ICT). Here, the authors show that blocking the phosphorylation of HRS to reduce the induction of immunosuppressive exosomes promotes CD8+ T-cell infiltration into tumors and enhances the efficacy of ICT in mouse melanoma models.

    • Lei Guan
    • , Bin Wu
    •  & Wei Guo
  • Article
    | Open Access

    T cells communicate with antigen-presenting cells (APC) via the signaling crosstalk at the immunological synapse (IS). Here the authors use bead-supported lipid bilayers as synthetic APCs to find that trans-synaptic vesicles produced by T cells in the IS carry specialized cargos distinct from constitutive extracellular vesicles to serve as intercellular messengers.

    • Pablo F. Céspedes
    • , Ashwin Jainarayanan
    •  & Michael L. Dustin
  • Article
    | Open Access

    Snf7 is the major component of the ESCRTIII membrane deformation system. Here, the authors used high-speed AFM to study Snf7 on nano-patterned and soft supports and show that loaded Snf7 spiral springs are curvature sensitive and deform membranes.

    • Nebojsa Jukic
    • , Alma P. Perrino
    •  & Simon Scheuring
  • Article
    | Open Access

    The fungal pathogen Candida albicans can release extracellular vesicles that promote biofilm formation and antifungal resistance. Here, Zarnowski et al. define functions for numerous vesicle cargo proteins in biofilm matrix assembly and drug resistance, as well as in fungal cell adhesion and dissemination.

    • Robert Zarnowski
    • , Andrea Noll
    •  & David R. Andes
  • Article
    | Open Access

    ESCRT-III complexes assemble in vivo inside membrane structures with a negative Gaussian curvature, but how membrane shape influences ESCRT-III polymerization remains unclear. Here authors use structural and biophysical methods to show how human ESCRT-III polymers assemble on positively curved membranes and induce helical membrane tube formation.

    • Aurélie Bertin
    • , Nicola de Franceschi
    •  & Patricia Bassereau
  • Article
    | Open Access

    The endosomal sorting complex required for transport-III (ESCRT-III) has been implicated in the packaging of HIV and HSV-1 viruses in the cytoplasm. Here the authors show that ESCRT-III proteins are required for the transport of HSV-1 nucleocapsids from nucleoplasm to cytosol through the nuclear envelope and confirm that the same mechanism is also used for the nucleocytoplasmic transport of RNP in Drosophila cells.

    • Jun Arii
    • , Mizuki Watanabe
    •  & Yasushi Kawaguchi
  • Article
    | Open Access

    Intraluminal vesicles are formed by the endosomal sorting complex required for transport (ESCRT) machinery. Here, the authors unravel the timing of vesicle budding, and that endosomal clathrin regulates concerted recruitment of ESCRT subcomplexes, required for efficient membrane remodeling.

    • Eva Maria Wenzel
    • , Sebastian Wolfgang Schultz
    •  & Camilla Raiborg
  • Article
    | Open Access

    During autophagy, phagophores elongate to form double-membrane vesicles but the mechanism behind their closure is unknown. Here, the authors develop an autophagy assay and find a role for the endosomal sorting complexes required for transport component CHMP2A as a phagophore closure regulator.

    • Yoshinori Takahashi
    • , Haiyan He
    •  & Hong-Gang Wang
  • Article |

    Mechanical activity predisposes muscle cell membranes to damage, which is repaired by a poorly defined Ca2+-dependent mechanism. Scheffer et al. describe the machinery for Ca2+-induced assembly of ESCRT III membrane remodelling complex at damaged cell membranes, which facilitates repair.

    • Luana L. Scheffer
    • , Sen Chandra Sreetama
    •  & Jyoti K. Jaiswal