Epilepsy articles from across Nature Portfolio

Epileptic seizure is one of the symptoms in patients with NGLY1 deficiency, a congenital disorder of deglycosylation. Here the authors show suppressive effects of oxytocin on seizure-like behaviors in a mouse model of NGLY1 deficiency.

SV2A is a receptor for botulinum neurotoxin (BoNT) and new generation antiepileptic drugs (AEDs). Here the authors report cryo-EM structures of SV2A in complex with BoNT receptor binding domain and AEDs highlighting the difference in the binding affinity between AEDs.

The posterior hippocampal tail is an important seizure node in humans and may be a promising interventional target in epilepsy.

Costa et al. designed a modular spiking neural network in a neuromorphic device with heterogeneous silicon neurons that remotely detects epileptiform discharges and High Frequency Oscillations in intra-operative EEG during epilepsy surgery in real-time.

Repetitive audio-visual stimulation, or sensory flicker, can modulate oscillations in a non-invasive manner. Here the authors demonstrate the potential of flicker in individuals with epilepsy undergoing intracranial seizure monitoring.

Status epilepticus is associated with changes in metabolic pathways, a new study has shown.

Brain somatic mosaicism is linked to several neurological disorders and is thought to arise post-zygotically. A study suggests that pre-zygotic aneuploidy followed by post-zygotic partial reversion leads to a recurrent form of brain mosaicism-related epilepsy.

A new study using the UK Biobank database has shown that people with epilepsy are at an increased risk of developing dementia. The results demonstrate that this risk is multiplied in individuals who also have high cardiovascular risk, highlighting the importance of addressing modifiable cardiovascular risk factors.