Epigenetics in immune cells articles from across Nature Portfolio

Epigenetics in immune cells is the study of changes in gene activity that persist following immune cell division and do not involve alteration of the nucleotide sequence. Epigenetic mechanisms include DNA methylation and chromatic remodelling and they provide a molecular basis for cellular memory.

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  • News & Views |

    The immune system is not immune to sex differences. New research now uncovers the molecular mechanisms that underlie sex-based differences during antiviral immune responses.

    • Alexandros Galaras
    •  & Mihalis Verykokakis
    Nature Immunology 24, 738-740
  • News & Views |

    During T cell activation, tRNA-m1A ‘writers’ TRMT61A and TRMT6 are upregulated to modify a group of early tRNA species and promote efficient translation of certain pre-cell-cycling proteins, thus ensuring rapid T cell proliferation and a timely adaptive immune response.

    Nature Immunology 23, 1408-1409
  • News & Views |

    Using high-resolution molecular and optical mapping of the three-dimensional genome, we found that the transcription factor TCF-1 is linked to changes in the structure of topologically associating domains in T cell progenitors that lead to interactions between previously insulated regulatory elements and target genes at late stages of T cell development.

    Nature Immunology 23, 1000-1001
  • News & Views |

    Alveolar macrophages (AMs), the resident macrophages of the lung, can be expanded ex vivo to generate large numbers of cells but show culture adaptations related to epigenetic and transcriptional changes. After transplantation into the lungs of mice, however, culture-expanded AMs lose these adaptations, fully restore in vivo identity and functionally reconstitute the AM pool.

    Nature Immunology 23, 358-359
  • News & Views |

    In the colonic environment, sustained Wnt–β-catenin activation in regulatory T cells promotes epigenetic rewiring toward proinflammatory RORγt+ Treg cells, whose expansion parallels the disease progression from inflammatory bowel disease (IBD) to manifest colorectal cancer (CRC).

    • Stefania Canè
    •  & Vincenzo Bronte
    Nature Immunology 22, 400-401