Epigenetics in immune cells

Epigenetics in immune cells is the study of changes in gene activity that persist following immune cell division and do not involve alteration of the nucleotide sequence. Epigenetic mechanisms include DNA methylation and chromatic remodelling and they provide a molecular basis for cellular memory.

Latest Research and Reviews

  • Research | | open

    The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD8 T cell differentiation via the Phf19/PRC2 axis, thereby implicating a novel aspect of cancer immunity regulation.

    • Yun Ji
    • , Jessica Fioravanti
    • , Wei Zhu
    • , Hongjun Wang
    • , Tuoqi Wu
    • , Jinhui Hu
    • , Neal E. Lacey
    • , Sanjivan Gautam
    • , John B. Le Gall
    • , Xia Yang
    • , James D. Hocker
    • , Thelma M. Escobar
    • , Shan He
    • , Stefania Dell’Orso
    • , Nga V. Hawk
    • , Veena Kapoor
    • , William G. Telford
    • , Luciano Di Croce
    • , Stefan A. Muljo
    • , Yi Zhang
    • , Vittorio Sartorelli
    •  & Luca Gattinoni
  • Research | | open

    Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4+ FoxP3+ Treg lineage, results in a dominant pathology in which ex-Treg cells and bystander T cells gain aberrant effector function.

    • Xiaojing Yue
    • , Chan-Wang J. Lio
    • , Daniela Samaniego-Castruita
    • , Xiang Li
    •  & Anjana Rao
  • Research | | open

    Here the authors examine how m6A modification is involved in innate immunity. They show that RNA methyltransferase Mettl3-mediated mRNA m6A methylation promotes dendritic cell (DC) activation and function, and in promoting DC-based T cells responses.

    • Huamin Wang
    • , Xiang Hu
    • , Mingyan Huang
    • , Juan Liu
    • , Yan Gu
    • , Lijia Ma
    • , Qi Zhou
    •  & Xuetao Cao
  • Reviews |

    Cells in the innate immune system can display adaptive characteristics that lead to increased responsiveness to secondary stimulation by pathogens. This innate immune memory has been termed ‘trained immunity’. Here, Mulder and colleagues describe the mechanisms responsible for the induction of trained immunity and propose strategies to regulate it as a potential treatment of immune-related diseases.

    • Willem J. M. Mulder
    • , Jordi Ochando
    • , Leo A. B. Joosten
    • , Zahi A. Fayad
    •  & Mihai G. Netea

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