Enzyme mechanisms : nature.com subject feedshttps://www.nature.com/subjects/enzyme-mechanisms.atom2024-03-28T16:02:21+00:00Methyl transfer in psilocybin biosynthesishttps://www.nature.com/articles/s41467-024-46997-z2024-03-28T00:00:00+00:002024-03-28T00:00:00+00:00Jesse Hudspeth et al.The reaction mechanism of the Ideonella sakaiensis PETase enzymehttps://www.nature.com/articles/s42004-024-01154-x2024-03-27T00:00:00+00:002024-03-27T00:00:00+00:00Tucker Burgin et al.Non-modular fatty acid synthases yield distinct N-terminal acylation in ribosomal peptideshttps://www.nature.com/articles/s41557-024-01491-32024-03-25T00:00:00+00:002024-03-25T00:00:00+00:00Hengqian Ren et al.Activation and friction in enzymatic loop opening and closing dynamicshttps://www.nature.com/articles/s41467-024-46723-92024-03-20T00:00:00+00:002024-03-20T00:00:00+00:00Kirill Zinovjev et al.Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomainhttps://www.nature.com/articles/s41467-024-46649-22024-03-19T00:00:00+00:002024-03-19T00:00:00+00:00Zhengrui Zhang et al.Two DOT1 enzymes cooperatively mediate efficient ubiquitin-independent histone H3 lysine 76 tri-methylation in kinetoplastidshttps://www.nature.com/articles/s41467-024-46637-62024-03-19T00:00:00+00:002024-03-19T00:00:00+00:00Victoria S. Frisbie et al.Mesoscale DNA features impact APOBEC3A and APOBEC3B deaminase activity and shape tumor mutational landscapeshttps://www.nature.com/articles/s41467-024-45909-52024-03-18T00:00:00+00:002024-03-18T00:00:00+00:00Ambrocio Sanchez et al.A signal transmission strategy driven by gap-regulated exonuclease hydrolysis for hierarchical molecular networkshttps://www.nature.com/articles/s42003-024-06036-52024-03-16T00:00:00+00:002024-03-16T00:00:00+00:00Xin Liu et al.Structural and mechanistic insights into activation of the human RNA ligase RTCB by Archeasehttps://www.nature.com/articles/s41467-024-46568-22024-03-16T00:00:00+00:002024-03-16T00:00:00+00:00Janina Lara Gerber et al.Substrate-induced condensation activates plant TIR domain proteinshttps://www.nature.com/articles/s41586-024-07183-92024-03-13T00:00:00+00:002024-03-13T00:00:00+00:00Wen Song et al.Substrate recognition mechanism of the endoplasmic reticulum-associated ubiquitin ligase Doa10https://www.nature.com/articles/s41467-024-46409-22024-03-11T00:00:00+00:002024-03-11T00:00:00+00:00Kevin Wu et al.A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12Dhttps://www.nature.com/articles/s41467-024-46363-z2024-03-08T00:00:00+00:002024-03-08T00:00:00+00:00Zhihong Xiao et al.Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexeshttps://www.nature.com/articles/s41467-024-46207-w2024-03-07T00:00:00+00:002024-03-07T00:00:00+00:00Sowmiya Palani et al.Author Correction: Shifted PAMs generate DNA overhangs and enhance SpCas9 post-catalytic complex dissociationhttps://www.nature.com/articles/s41594-024-01247-02024-03-05T00:00:00+00:002024-03-05T00:00:00+00:00Jinglong Wang et al.DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydridehttps://www.nature.com/articles/s41467-024-46391-92024-03-05T00:00:00+00:002024-03-05T00:00:00+00:00Aizhan Akhmadi et al.A non-canonical nucleophile unlocks a new mechanistic pathway in a designed enzymehttps://www.nature.com/articles/s41467-024-46123-z2024-03-04T00:00:00+00:002024-03-04T00:00:00+00:00Amy E. Hutton et al.Filament formation drives catalysis by glutaminase enzymes important in cancer progressionhttps://www.nature.com/articles/s41467-024-46351-32024-03-04T00:00:00+00:002024-03-04T00:00:00+00:00Shi Feng et al.Structural insight into an Arl1–ArfGEF complex involved in Golgi recruitment of a GRIP-domain golginhttps://www.nature.com/articles/s41467-024-46304-w2024-03-02T00:00:00+00:002024-03-02T00:00:00+00:00H. Diessel Duan et al.A unified view on enzyme catalysis by cryo-EM study of a DNA topoisomerasehttps://www.nature.com/articles/s42004-024-01129-y2024-02-28T00:00:00+00:002024-02-28T00:00:00+00:00Chiung-Wen Mary Chang et al.Substrate binding and catalytic mechanism of the Se-glycosyltransferase SenB in the biosynthesis of selenoneinehttps://www.nature.com/articles/s41467-024-46065-62024-02-23T00:00:00+00:002024-02-23T00:00:00+00:00Wei Huang et al.Epistasis arises from shifting the rate-limiting step during enzyme evolution of a β-lactamasehttps://www.nature.com/articles/s41929-024-01117-42024-02-23T00:00:00+00:002024-02-23T00:00:00+00:00Christopher Fröhlich et al.Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesishttps://www.nature.com/articles/s41594-024-01237-22024-02-22T00:00:00+00:002024-02-22T00:00:00+00:00Kexin Hu et al.The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER transloconshttps://www.nature.com/articles/s41586-024-07093-w2024-02-21T00:00:00+00:002024-02-21T00:00:00+00:00Linda Makhlouf et al.Distinct functional constraints driving conservation of the cofilin N-terminal regulatory tailhttps://www.nature.com/articles/s41467-024-45878-92024-02-16T00:00:00+00:002024-02-16T00:00:00+00:00Joel A. Sexton et al.Carotenoid cleavage enzymes evolved convergently to generate the visual chromophorehttps://www.nature.com/articles/s41589-024-01554-z2024-02-14T00:00:00+00:002024-02-14T00:00:00+00:00Yasmeen J. Solano et al.An intramolecular macrocyclase in plant ribosomal peptide biosynthesishttps://www.nature.com/articles/s41589-024-01552-12024-02-14T00:00:00+00:002024-02-14T00:00:00+00:00Lisa S. Mydy et al.Selenium abandons selenoproteins to inhibit ferroptosis rapidlyhttps://www.nature.com/articles/s42255-024-00980-62024-02-13T00:00:00+00:002024-02-13T00:00:00+00:00Ian G. Chambers et al.Biocatalytic strategy for the construction of sp3-rich polycyclic compounds from directed evolution and computational modellinghttps://www.nature.com/articles/s41557-023-01435-32024-02-13T00:00:00+00:002024-02-13T00:00:00+00:00David A. Vargas et al.Selenium reduction of ubiquinone via SQOR suppresses ferroptosishttps://www.nature.com/articles/s42255-024-00974-42024-02-13T00:00:00+00:002024-02-13T00:00:00+00:00Namgyu Lee et al.Poly-γ-glutamylation of biomoleculeshttps://www.nature.com/articles/s41467-024-45632-12024-02-12T00:00:00+00:002024-02-12T00:00:00+00:00Ghader Bashiri et al.