Endosomes are membrane-delimited intracellular transport carriers. Three main endosome compartments exist: early, late and recycling endosomes. Early endosomes mature into late endosomes that subsequently fuse with lysosomes. Recycling endosomes are a sub-compartment of early endosomes that return material to the plasma membrane. Endosomes form at the plasma membrane or the Golgi.

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News and Comment

  • News and Views |

    Membrane trafficking specificity between distinct compartments ensures that cargo proteins and lipids are delivered to their target organelle. However, accurate recognition of cargo carriers by tethering factors on target membranes is poorly understood. TBC1D23 is now identified as an adaptor that links endosome-derived vesicles with golgins at the trans-Golgi.

    • J. Christopher Fromme
    •  & Mary Munson
    Nature Cell Biology 19, 1384-1386
  • News and Views |

    Recycling from endosomes to the plasma membrane is an important step in cell homeostasis. The retromer/SNX27/WASH complex recycles numerous receptors, but key ones are still unaccounted for. Now a related conserved heterotrimer, called retriever, has been identified that, together with SNX17, the CCC complex and WASH, mediates the recycling of α5β1 integrins.

    • Catherine Rabouille
    Nature Cell Biology 19, 1144-1146
  • News and Views |

    The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.

    • Elena Rainero
    •  & Jim C. Norman
    Nature Cell Biology 17, 1373-1375
  • News and Views |

    How proteins migrate through the interconnected organelles of the endolysosomal system is poorly understood. A piece of the puzzle has been added with the identification of a complex of tethering factors that functions in the recycling of proteins towards the cell surface.

    • Yann Desfougères
    • , Massimo D'Agostino
    •  & Andreas Mayer
    Nature Cell Biology 17, 540-541