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| Open AccessReal-time holographic lensless micro-endoscopy through flexible fibers via fiber bundle distal holography
Fiber-based micro-endoscopes are minimally invasive, but 3D imaging is limited by the need for bulky optical elements or rigid fibers. Here, the authors demonstrate holographic imaging through flexible and dynamically bent multi-core fibers by adding partially reflecting mirror to the distal fiber-tip.
- Noam Badt
- & Ori Katz
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Article
| Open AccessFlexible-type ultrathin holographic endoscope for microscopic imaging of unstained biological tissues
Lensless fibre endoscopes are minimally invasive, but are often rigid and require calibration and fluorescence labelling. Here, the authors present a flexible endoscope based on a bare fibre bundle and a lensless Fourier holographic imaging configuration to detect weak reflections from unstained biological tissues.
- Wonjun Choi
- , Munkyu Kang
- & Wonshik Choi
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Article
| Open AccessA neurovascular high-frequency optical coherence tomography system enables in situ cerebrovascular volumetric microscopy
High resolution intravascular imaging in the brain is limited by the high tortuosity of the vasculature. Here the authors present a fiber optic imaging technology using high-frequency optical coherence tomography (HF-OCT) to provide volumetric high resolution images in the highly tortuous cerebral vasculature.
- Giovanni J. Ughi
- , Miklos G. Marosfoi
- & Ajit S. Puri
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| Open AccessHeterogeneity in tumor chromatin-doxorubicin binding revealed by in vivo fluorescence lifetime imaging confocal endomicroscopy
The engagement of DNA-binding drugs to their target is difficult to study, particularly in vivo. Here the authors develop an in vivo fluorescence lifetime imaging confocal laparo/endomicroscope to show intra- and inter-tumor heterogeneity in doxorubicin binding to peritoneal metastases, which depends on the route of administration.
- Hugh Sparks
- , Hiroshi Kondo
- & Erik Sahai
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| Open AccessLongitudinal intravital imaging of the femoral bone marrow reveals plasticity within marrow vasculature
Longitudinal imaging of bone marrow would shed insight into long-term cellular dynamics within this compartment. Here, the authors develop a multi-photon imaging approach for the mouse femur and reveal extensive vascular plasticity within the bone marrow during bone healing and steady-state homeostasis.
- David Reismann
- , Jonathan Stefanowski
- & Raluca A. Niesner
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| Open AccessSuper-achromatic monolithic microprobe for ultrahigh-resolution endoscopic optical coherence tomography at 800 nm
Optical coherence tomography is an established optical tool for in vivo clinical imaging and diagnosis applications, but endoscopic technologies remain limited. Here, Yuan et al. develop a flexible, narrow diameter, super-achromatic endoscopic probe for ultrahigh-resolution in vivo OCT imaging of small luminal organs or narrow constrictions.
- Wu Yuan
- , Robert Brown
- & Xingde Li