Endoplasmic reticulum

The endoplasmic reticulum (ER) is a compartment (organelle) in eukaryotic cells that consists of membrane sacs called cisternae. Because of the bound ribosomes, the 'rough' ER is the site of synthesis of various proteins and is where newly synthesized proteins are modified by glycosylation. The 'smooth' ER is a site for lipid and carbohydrate metabolism.

Latest Research and Reviews

Research
10 August 2022 | Open Access

Molecular basis of MHC I quality control in the peptide loading complex

The immune system monitors the health status of cells by surveilling fragments of foreign molecules from invaders presented on MHC I complexes at the cell surface. Here, the authors investigate the sequence of events of MHC I assembly and quality control cycle.
- Alexander Domnick
- , Christian Winter
- & Robert Tampé
Nature Communications 13, 4701
Research
25 July 2022 | Open Access

Empagliflozin mitigates endothelial inflammation and attenuates endoplasmic reticulum stress signaling caused by sustained glycocalyx disruption
- Marc-Antoine Campeau
- & Richard L. Leask
Scientific Reports 12, 12681
Research
13 July 2022 | Open Access

Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability
- Takumi Taketomi
- , Takunori Yasuda
- & Fuminori Tsuruta
Scientific Reports 12, 11891
Research
28 June 2022 | Open Access

Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites

The ER-mitochondria contact sites are crucial for exchanging phospholipids. Here, Kim et al. present crystal structures of mitoguardin-2 (MIGA2) which reveal that MIGA2 directly binds phospholipids and transfers them between the ER and mitochondria.
- Hyunwoo Kim
- , Seowhang Lee
- & Changwook Lee
Nature Communications 13, 3702
Research
24 May 2022 | Open Access

Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells
- Hiroki Tanemura
- , Kenji Masuda
- & Ryo Ushioda
Scientific Reports 12, 7239
Research
19 May 2022 | Open Access

Shielding of actin by the endoplasmic reticulum impacts nuclear positioning

The nucleus connects to the actin cytoskeleton for nuclear movement in migrating cells. Here, the authors show that the endoplasmic reticulum shields actin cables to generate asymmetric nucleo-cytoskeleton connections for nuclear positioning.
- Cátia Silva Janota
- , Andreia Pinto
- & Edgar R. Gomes
Nature Communications 13, 2763

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News and Comment

Research Highlights | 07 June 2022

End of the road: from the ER to the proteasome

James Olzmann discusses the groundbreaking work of Ron Kopito and colleagues, which demonstrated that a CFTR mutant is ubiquitinated and degraded by the cytosolic 26S proteasome. This discovery contributed to our understanding of ERAD and had important implications for the development of therapeutic agents for cystic fibrosis.
- James A. Olzmann
Nature Reviews Molecular Cell Biology 23, 520
News & Views | 25 April 2022

Sustainable bioimaging using a fluorescent protein with unprecedented photostability

The jellyfish-derived green fluorescent protein StayGold is bright and hardly fades, contributing to improving spatiotemporal resolution and dramatically extending the observation period. To fully benefit from the rich photon budget, we tried some unusual illumination modalities for sustainable, quantitative live-cell or volumetric imaging.

Nature Biotechnology 40, 1011-1012
News & Views | 11 April 2022

Membranes regulate biomolecular condensates

Biomolecular condensation has emerged as a fundamental mechanism for cellular organization, but less is known about the regulation of condensate subcellular location and size. A new study reports that membrane tethering of protein and RNA directly influences the assembly, size and material properties of ribonucleic condensates.
- Lindsay B. Case
Nature Cell Biology 24, 404-405
Correspondence
13 September 2021 | Open Access

TMEM151A variants cause paroxysmal kinesigenic dyskinesia
- Hong-Fu Li
- , Yu-Lan Chen
- & Zhi-Ying Wu
Cell Discovery 7, 83
Research Highlights | 25 August 2021

Neuronal organelle contacts
- Jake Rogers
Nature Reviews Neuroscience 22, 591
Research Highlights | 25 June 2021

Reshape to survive
- Majda Bratovič
Nature Chemical Biology 17, 749

All News & Comment

Endoplasmic reticulum

Latest Research and Reviews

Molecular basis of MHC I quality control in the peptide loading complex

Empagliflozin mitigates endothelial inflammation and attenuates endoplasmic reticulum stress signaling caused by sustained glycocalyx disruption

Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability

Structural basis for mitoguardin-2 mediated lipid transport at ER-mitochondrial membrane contact sites

Development of a stable antibody production system utilizing an Hspa5 promoter in CHO cells

Shielding of actin by the endoplasmic reticulum impacts nuclear positioning

News and Comment

End of the road: from the ER to the proteasome

Sustainable bioimaging using a fluorescent protein with unprecedented photostability

Membranes regulate biomolecular condensates

TMEM151A variants cause paroxysmal kinesigenic dyskinesia

Neuronal organelle contacts

Reshape to survive

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