Embryonic stem cells

Embryonic stem cells are pluripotent cells isolated from the inner cell mass of a blastocyst, the early mammalian embryo that implants into the uterus. Embryonic stem cells self-renew by dividing and can differentiate into any specialised cell of the body, but not extra-embryonic tissues such as the placenta.

Latest Research and Reviews

  • Research | | open

    Transposable elements (TEs) fulfill essential but poorly understood roles in genome organization and gene expression control. Here the authors show that the regulation of TEs occurs through overlapping epigenetic mechanisms that control the expression and chromatin signatures at TEs.

    • Jiangping He
    • , Xiuling Fu
    • , Meng Zhang
    • , Fangfang He
    • , Wenjuan Li
    • , Mazid Md. Abdul
    • , Jianguo Zhou
    • , Li Sun
    • , Chen Chang
    • , Yuhao Li
    • , He Liu
    • , Kaixin Wu
    • , Isaac A. Babarinde
    • , Qiang Zhuang
    • , Yuin-Han Loh
    • , Jiekai Chen
    • , Miguel A. Esteban
    •  & Andrew P. Hutchins
  • Research | | open

    Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a ground-state pluripotency-like gene network.

    • Derrick C. Wan
    • , Stefanie L. Morgan
    • , Andrew L. Spencley
    • , Natasha Mariano
    • , Erin Y. Chang
    • , Gautam Shankar
    • , Yunhai Luo
    • , Ted H. Li
    • , Dana Huh
    • , Star K. Huynh
    • , Jasmine M. Garcia
    • , Cole M. Dovey
    • , Jennifer Lumb
    • , Ling Liu
    • , Katharine V. Brown
    • , Abel Bermudez
    • , Richard Luong
    • , Hong Zeng
    • , Victoria L. Mascetti
    • , Sharon J. Pitteri
    • , Jordon Wang
    • , Hua Tu
    • , Marco Quarta
    • , Vittorio Sebastiano
    • , Roel Nusse
    • , Thomas A. Rando
    • , Jan E. Carette
    • , J. Fernando Bazan
    •  & Kevin C. Wang
  • Research | | open

    Reprogramming of mitochondria metabolism occurs during naïve to primed pluripotency differentiation in mouse embryonic stem cells (ESCs). Here the authors show that mitochondrial MTCH2 regulates mitochondrial fusion and that this fusion is required for naïve to primed pluripotency conversion

    • Amir Bahat
    • , Andres Goldman
    • , Yehudit Zaltsman
    • , Dilshad H. Khan
    • , Coral Halperin
    • , Emmanuel Amzallag
    • , Vladislav Krupalnik
    • , Michael Mullokandov
    • , Alon Silberman
    • , Ayelet Erez
    • , Aaron D. Schimmer
    • , Jacob H. Hanna
    •  & Atan Gross
  • Research | | open

    Diseases such as diabetes and Parkinson's manifest based on interactions between genes and environment. Here, the authors find among a panel of cell types that propargite, a common pesticide, induces pancreatic β-cell and dopamine neuron death and that loss of the gene GSTT1 confers hypersensitivity.

    • Ting Zhou
    • , Tae Wan Kim
    • , Chi Nok Chong
    • , Lei Tan
    • , Sadaf Amin
    • , Zohreh Sadat Badieyan
    • , Suranjit Mukherjee
    • , Zaniar Ghazizadeh
    • , Hui Zeng
    • , Min Guo
    • , Miguel Crespo
    • , Tuo Zhang
    • , Reyn Kenyon
    • , Christopher L. Robinson
    • , Effie Apostolou
    • , Hui Wang
    • , Jenny Zhaoying Xiang
    • , Todd Evans
    • , Lorenz Studer
    •  & Shuibing Chen
  • Research | | open

    Self-renewal and pluripotency of human embryonic stem cells (hESCs) depends upon the function of the transcription factor OCT4. Here, the authors identified proteins associated with the OCT4 enhancer, notably ZNF207 that maintains both pluripotency and differentiation towards ectoderm through isoform switching.

    • Fang Fang
    • , Ninuo Xia
    • , Benjamin Angulo
    • , Joseph Carey
    • , Zackery Cady
    • , Jens Durruthy-Durruthy
    • , Theo Bennett
    • , Vittorio Sebastiano
    •  & Renee A. Reijo Pera

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