Embryogenesis

Cheng, Mittnenzweig et al. demonstrate the cellular role of the major DNA demethylation machinery, ten-eleven translocation (TET) dioxygenases, in early mammalian development.

Marta Shahbazi recounts the work by Lewis and Rossant (1982) that pioneered research on size regulation in mammalian embryos.

Luciano Marcon discusses the revolutionary work by Alan Turing proposing that embryogenesis could be entirely a self-organizing process.

A recent study reports the development of Stereo-seq (spatial enhanced resolution omics-sequencing) and its application to generate a spatiotemporal transcriptomic atlas of mouse organogenesis.

The first single-cell transcriptome of the gastrulating human embryo.

Blastoids (blastocyst-like structures) that accurately model human blastocyst development and are capable of implantation are generated, potentially opening up new avenues for basic and clinical research.