Ebola virus

Ebola virus is an infectious agent and one of the viruses that can cause haemorraghic fever, a severe infectious disease characterized by high fever and bleeding, in humans and some monkeys. The first infections with this viral genus were reported in Zaire, close to the river Ebola.

Latest Research and Reviews

  • Research
    | Open Access

    During an ongoing Ebola virus outbreak, infection before onset of protective immunity from vaccination is a possible scenario. Here the authors show in non-human primates that vaccination shortly before treatment with a monoclonal antibody does not negatively affect effectiveness of the antibody therapy.

    • Robert W. Cross
    • , Zachary A. Bornholdt
    • , Abhishek N. Prasad
    • , Joan B. Geisbert
    • , Viktoriya Borisevich
    • , Krystle N. Agans
    • , Daniel J. Deer
    • , Kevin Melody
    • , Karla A. Fenton
    • , Heinz Feldmann
    • , Armand Sprecher
    • , Larry Zeitlin
    •  & Thomas W. Geisbert
  • Reviews |

    Bats harbour a large number of different viruses, some of which have spilled over to cause human disease. In this Review, Letko, Munster and colleagues discuss the diversity of bat viruses and the factors that determine the emergence of zoonotic viruses from bats.

    • Michael Letko
    • , Stephanie N. Seifert
    • , Kevin J. Olival
    • , Raina K. Plowright
    •  & Vincent J. Munster
  • Research
    | Open Access

    Here, Kuroda et al. screen a library of nearly 400 interferon-stimulated genes (ISGs) and identify several ISGs that inhibit Ebola virus entry, viral transcription/replication, or virion formation. The study provides insights into interactions between Ebola and the host cells.

    • Makoto Kuroda
    • , Peter J. Halfmann
    • , Lindsay Hill-Batorski
    • , Makoto Ozawa
    • , Tiago J. S. Lopes
    • , Gabriele Neumann
    • , John W. Schoggins
    • , Charles M. Rice
    •  & Yoshihiro Kawaoka
  • Reviews |

    Filoviruses such as Ebola virus pose a substantial health risk to humans. Advances in genomic technologies have enabled the rapid, large-scale generation of virus sequence data at the location of disease outbreaks and thus the use of reverse functional genomics to swiftly characterize the threat of, and treatment for, filovirus disease.

    • Nicholas Di Paola
    • , Mariano Sanchez-Lockhart
    • , Xiankun Zeng
    • , Jens H. Kuhn
    •  & Gustavo Palacios
  • Reviews |

    Ebola virus disease (EVD) is caused by the filovirus Ebola virus (EBOV). Although the natural host of EBOV is undefined, a single zoonotic transmission is the probable start of most EVD outbreaks. EVD is characterized by gastrointestinal manifestations and multiple organ dysfunction syndrome and has a high case–fatality rate.

    • Shevin T. Jacob
    • , Ian Crozier
    • , William A. Fischer II
    • , Angela Hewlett
    • , Colleen S. Kraft
    • , Marc-Antoine de La Vega
    • , Moses J. Soka
    • , Victoria Wahl
    • , Anthony Griffiths
    • , Laura Bollinger
    •  & Jens H. Kuhn
  • Research
    | Open Access

    • Lisa Evans DeWald
    • , Joshua C. Johnson
    • , Dawn M. Gerhardt
    • , Lisa M. Torzewski
    • , Elena Postnikova
    • , Anna N. Honko
    • , Krisztina Janosko
    • , Louis Huzella
    • , William E. Dowling
    • , Ann E. Eakin
    • , Blaire L. Osborn
    • , Janet Gahagen
    • , Liang Tang
    • , Carol E. Green
    • , Jon C. Mirsalis
    • , Michael R. Holbrook
    • , Peter B. Jahrling
    • , Julie Dyall
    •  & Lisa E. Hensley

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