Drug regulation articles within Nature Communications

Featured

  • Article
    | Open Access

    Microneedle patches that can actively address individual needles are challenging to realize. Here, the authors introduce a spatiotemporal on-demand patch for precise and personalized drug delivery, utilizing electrically triggered control with drug-loaded microneedles and biocompatible metallic membranes.

    • Yihang Wang
    • , Zeka Chen
    •  & Wubin Bai

  • Article
    | Open Access

    CCAAT/enhancer binding protein α (C/EBPα) regulates myeloid differentiation, and its dysregulation contributes to acute myeloid leukaemia progress. Here the authors show that homodimer-mediated phosphorylation of C/EBPα-p42 modulates acute myeloid leukaemia cell differentiation by liquid-liquid phase separation.

    • Dongmei Wang
    • , Tao Sun
    •  & Chunyan Ji

  • Article
    | Open Access

    Leishmania is a unicellular protozoan that has limited transcriptional control. Here, the authors show that translational control is a major mechanism of antimony drug resistance in Leishmania. They observe a dramatic translatome reprogramming during development of resistance to the drug and report translational control as a major driver of antimony-resistant phenotypes.

    • Sneider Alexander Gutierrez Guarnizo
    • , Elena B. Tikhonova
    •  & Zemfira N. Karamysheva

  • Article
    | Open Access

    Here the authors propose an RNA interference-based switch for dynamic control of AAV transgene expression. In this approach, transgene expression may be silenced by RNAi and subsequently recovered using REVERSIR oligonucleotides.

    • Megha Subramanian
    • , James McIninch
    •  & Vasant Jadhav

  • Article
    | Open Access

    Chemodynamic therapy relies on Fenton or Fenton-like reactions to produce hydroxyl radical in the tumor region. Here the authors design a two-dimensional interplanar heterojunction with in situ hydroxyl radical generation under ultrasound irradiation, showing anti-cancer activity in preclinical models.

    • Yong Kang
    • , Zhuo Mao
    •  & Xiaoyuan Ji

  • Article
    | Open Access

    The circadian clock is an internal mechanism that controls various physiological processes, such as the sleep-wake cycle, but its precise regulation is challenging. Here, the authors develop a visible light-responsive inhibitor of casein kinase I which controls the period and phase of cellular and tissue circadian rhythms in a reversible manner.

    • Dušan Kolarski
    • , Carla Miró-Vinyals
    •  & Ben L. Feringa

  • Article
    | Open Access

    Generics contribute to increased availability of antibiotics, benefiting healthcare systems but potentially leading to increased consumption with implications for antibiotic stewardship and resistance. Here, the authors found no consistent changes in prescribing patterns of the 13 antibiotics that entered the US market as generics from 2000–2012.

    • Cecilia Kållberg
    • , Jemma Hudson
    •  & Ramanan Laxminarayan

  • Article
    | Open Access

    Triple negative breast cancer is a deadly form of breast cancer with limited therapeutic options. Here the authors show the efficacy of GLUT1 pharmacological inhibition against a subset of tumors expressing RB1, thereby identifying RB1 protein level as a biomarker of sensitivity to anti-GLUT1 therapy.

    • Qin Wu
    • , Wail ba-alawi
    •  & Cheryl H. Arrowsmith

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