Drug discovery articles from across Nature Portfolio

Drug discovery is the process through which potential new medicines are identified. It involves a wide range of scientific disciplines, including biology, chemistry and pharmacology.

Featured

News & Views | 27 March 2023

Illuminating anti-ageing
- Yunjie Xu
- , Jong Seung Kim
- & Mingle Li
Nature Chemistry, 1-2
News & Views | 15 March 2023

Inhibition of the protein menin shows early promise in leukaemia

Nature

Latest Research and Reviews

Research
30 March 2023 | Open Access

Results of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder
- Lauren M. Schmitt
- , Elizabeth G. Smith
- & Craig A. Erickson
Scientific Reports 13, 5192
Reviews | 30 March 2023

Peptidomics

Peptidomics employs techniques of genomics, modern proteomics, state-of-the-art analytical chemistry and computational biology. In this Primer, Hellinger et al. describe the techniques and workflows required for peptide discovery and characterization and give an overview of biological and clinical applications of peptidomics.
- Roland Hellinger
- , Arnar Sigurdsson
- & Christian W. Gruber
Nature Reviews Methods Primers 3, 25
Research
30 March 2023 | Open Access

ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation
- Huiting Deng
- , Hailin Liu
- & Yahui Ding
Oncogenesis 12, 19
Research | 29 March 2023

Comprehensive analysis of biosynthetic gene clusters in bacteria and discovery of Tumebacillus as a potential producer of natural products
- Yuta Kikuchi
- , Miku Kawashima
- & Yuki Inahashi
The Journal of Antibiotics, 1-8
Reviews
29 March 2023 | Open Access

Evolving regulatory perspectives on digital health technologies for medicinal product development
- Seya Colloud
- , Thomas Metcalfe
- & Francesca Cerreta
npj Digital Medicine 6, 56
Research
29 March 2023 | Open Access

Automated high-throughput image processing as part of the screening platform for personalized oncology
- Marcel P. Schilling
- , Razan El Khaled El Faraj
- & Markus Reischl
Scientific Reports 13, 5107

All Research & Reviews

News and Comment

News | 28 March 2023

Antibody-patent row could have far-reaching impact on biotech

The results of a US case could dictate how broad patents are, and have knock-on effects for those developing drugs.
- Heidi Ledford
Nature
Comments & Opinion | 27 March 2023

Cell membrane anchoring strategies for HIV gene therapy
- Yani Gong
- & Yuxian He
Cellular & Molecular Immunology, 1-3
News & Views | 27 March 2023

Illuminating anti-ageing

Therapies that destroy senescent cells could be used to alleviate age-related disease, yet conventional drugs often suffer from low selectivity and unwanted side effects. Now, a photosensitive agent has been developed that is activated in situ in senescent cells, enabling their selective elimination.
- Yunjie Xu
- , Jong Seung Kim
- & Mingle Li
Nature Chemistry, 1-2
Comments & Opinion | 15 March 2023

Distinguishing and predicting drug patents

Drug patents are different. To improve their quality ex ante, regulators can use predictive models.
- Colleen V. Chien
- , Nicholas Halkowski
- & Jeffrey Kuhn
Nature Biotechnology 41, 317-321
News & Views | 15 March 2023

Inhibition of the protein menin shows early promise in leukaemia

Leukaemias characterized by the rearrangement of the gene KMT2A or mutation of the NPM1 gene depend on the protein menin. In a first-in-human trial, the menin inhibitor revumenib had minimal severe adverse effects and showed promising clinical activity in individuals with these types of leukaemia.

Nature
Research Highlights | 10 March 2023

Organoids illuminate NAFLD pathogenesis
- M. Teresa Villanueva
Nature Reviews Drug Discovery

All News & Comment

Drug discovery articles from across Nature Portfolio

Featured

Illuminating anti-ageing

Inhibition of the protein menin shows early promise in leukaemia

Latest Research and Reviews

Results of a phase Ib study of SB-121, an investigational probiotic formulation, a randomized controlled trial in participants with autism spectrum disorder

Peptidomics

ACT001 inhibited CD133 transcription by targeting and inducing Olig2 ubiquitination degradation

Comprehensive analysis of biosynthetic gene clusters in bacteria and discovery of Tumebacillus as a potential producer of natural products

Evolving regulatory perspectives on digital health technologies for medicinal product development

Automated high-throughput image processing as part of the screening platform for personalized oncology

News and Comment

Antibody-patent row could have far-reaching impact on biotech

Cell membrane anchoring strategies for HIV gene therapy

Illuminating anti-ageing

Distinguishing and predicting drug patents

Inhibition of the protein menin shows early promise in leukaemia

Organoids illuminate NAFLD pathogenesis

Search

Quick links

Drug discovery articles from across Nature Portfolio

Featured

Related Subjects

Latest Research and Reviews

News and Comment

Search

Quick links