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C16, a PKR inhibitor, suppresses cell proliferation by regulating the cell cycle via p21 in colorectal cancer
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Statine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV‑2 Mpro)
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Affinity chromatography reveals direct binding of the GATA4–NKX2-5 interaction inhibitor (3i-1000) with GATA4
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Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC
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Dissolution and antioxidant potential of apigenin self nanoemulsifying drug delivery system (SNEDDS) for oral delivery
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In silico exploration of phenolics as modulators of penicillin binding protein (PBP) 2× of Streptococcus pneumoniae
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Sirolimus-coated Eustachian tube balloon dilatation for treating Eustachian tube dysfunction in a rat model
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Molecular modelling studies and in vitro enzymatic assays identified A 4-(nitrobenzyl)guanidine derivative as inhibitor of SARS-CoV-2 Mpro
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Development of a high throughput system to screen compounds that revert the activated hepatic stellate cells to a quiescent-like state
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Molecular identification of Proteus mirabilis, Vibrio species leading to CRISPR-Cas9 modification of tcpA and UreC genes causing cholera and UTI
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Design, synthesis, biological assessment and molecular modeling studies of novel imidazothiazole-thiazolidinone hybrids as potential anticancer and anti-inflammatory agents
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Using Mendelian randomization provides genetic insights into potential targets for sepsis treatment
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Anticancer, antioxidant, and antibacterial activity of chemically fingerprinted extract from Cyclamen persicum Mill.
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Translational research of boron neutron capture therapy for spinal cord gliomas using rat model
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DP2 receptor activity sensor suited for antagonist screening and measurement of receptor dynamics in real-time
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Development of chitosan lipid nanoparticles to alleviate the pharmacological activity of piperine in the management of cognitive deficit in diabetic rats
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TDF and TAF inhibit liver cancer cell migration, invasion via p7TP3
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Inferring molecular inhibition potency with AlphaFold predicted structures
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Hibiscus manihot L. flower extract induces anticancer activity through modulation of apoptosis and autophagy in A549 cells
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Investigation into safflower injection as a prophylactic treatment for retinal vein occlusion in a rabbit model
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EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy
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Nobiletin alleviates cisplatin-induced ototoxicity via activating autophagy and inhibiting NRF2/GPX4-mediated ferroptosis
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AI is a viable alternative to high throughput screening: a 318-target study
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Rosemary and neem: an insight into their combined anti-dandruff and anti-hair loss efficacy
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The antihyperglycemic potential of pyrazolobenzothiazine 1, 1-dioxide novel derivative in mice using integrated molecular pharmacological approach
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UTRN as a potential biomarker in breast cancer: a comprehensive bioinformatics and in vitro study
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Anethole as a promising antidepressant for maternal separation stress in mice by modulating oxidative stress and nitrite imbalance
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A combination of virtual screening, molecular dynamics simulation, MM/PBSA, ADMET, and DFT calculations to identify a potential DPP4 inhibitor
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B-Myb deficiency boosts bortezomib-induced immunogenic cell death in colorectal cancer
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Synthesis and biological evaluation of echinomycin analogues as potential colon cancer agent
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Tenovin 3 induces apoptosis and ferroptosis in EGFR 19del non small cell lung cancer cells
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Comparison of efficacy and safety of equivalent doses of remimazolam versus propofol for gastroscopy anesthesia in elderly patients
- Di Chen
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Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell
- Ashraf H. F. Abd El-Wahab
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Podocalyxin promotes the formation of compact and chemoresistant cancer spheroids in high grade serous carcinoma
- Ngoc Le Tran
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Network pharmacology, computational biology integrated surface plasmon resonance technology reveals the mechanism of ellagic acid against rotavirus
- Jiangang Zheng
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A new DNA aptamer which binds to SARS-CoV-2 spike protein and reduces pro-inflammatory response
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Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors
- Mina Sadeghi Ganjeh
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Real-time analysis of osteoclast resorption and fusion dynamics in response to bone resorption inhibitors
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Effect of sulfasalazine on ferroptosis during intestinal injury in rats after liver transplantation
- Wei Wu
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Escherichia coli has an undiscovered ability to inhibit the growth of both Gram-negative and Gram-positive bacteria
- Ertan Kastrat
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GEFormerDTA: drug target affinity prediction based on transformer graph for early fusion
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Overcoming radioresistance of breast cancer cells with MAP4K4 inhibitors
- Yun-Suk Kwon
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Potential diagnostic and drug target markers in glioblastoma
- Hina Ahsan
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Network pharmacology analysis and experimental validation to explore the mechanism of kaempferol in the treatment of osteoporosis
- Qi Dong
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Background and clinical significance of biomarker-based patient enrichment in non-small-cell lung cancer drug development
- Kenji Harada
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Nuciferine reduces vascular leakage and improves cardiac function in acute myocardial infarction by regulating the PI3K/AKT pathway
- Wei Xie
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- & Dongjin Wang
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Fully connected-convolutional (FC-CNN) neural network based on hyperspectral images for rapid identification of P. ginseng growth years
- Xingfeng Chen
- , Hejuan Du
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A comprehensive computational study to explore promising natural bioactive compounds targeting glycosyltransferase MurG in Escherichia coli for potential drug development
- Amneh Shtaiwi
- , Shafi Ullah Khan
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Correlation analysis of disulfidptosis-related gene signatures with clinical prognosis and immunotherapy response in sarcoma
- Juan Xu
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Narazaciclib, a novel multi-kinase inhibitor with potent activity against CSF1R, FLT3 and CDK6, shows strong anti-AML activity in defined preclinical models