Double-strand DNA breaks articles from across Nature Portfolio

A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation. They are particularly deleterious as the DNA ends can promote potentially lethal chromosomal rearrangements, and can be repaired by homologous recombination (HR) or non-homologous-end joining (NHEJ).


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