DNA nanotechnology

DNA-based dynamic networks show adaptation to external stimuli toward the generation of the fittest constituent. This selection principle has now been implemented to control the catalytic efficiency of an enzymatic reaction.

Programmable DNA building blocks hosting diverse nano-objects assemble into three-dimensional nanoparticle lattices whose geometry is determined by the shape and valence of the DNA block.

The complexity of DNA-programmed nanoparticle assemblies has reached an unprecedented level owing to recent advances that enable delicate and comprehensive control over the formation of DNA bonds.

A molecular reaction network translated from a computer-trained classifier can distinguish lung cancer patients from healthy individuals based on specific microRNAs in the blood.

A rod-shaped molecular motor constructed from DNA rolls in a straight line across an RNA-functionalized surface.

RNA has multiple roles in biology, enabled by its structural diversity. Now, artificially grafted RNA motifs have been encoded in a single RNA strand to form self-assembling nanostructures with controlled geometry and function.