DNA damage and repair articles from across Nature Portfolio

DNA damage and repair refers to the creation and correction of DNA lesions that threaten genome integrity. Because DNA replication errors or environmental agents that damage DNA can introduce mutations if not corrected, multiple cellular DNA repair mechanisms exist to remove damaged regions of chromosomes to prevent these potentially deleterious effects.

Latest Research and Reviews

Research
23 March 2023 | Open Access

The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities

In this work, the authors show that the DREAM complex suppresses the expression of numerous DNA-repair proteins in somatic cells. Suppression of the DREAM complex, either by altering individual components in Caenorhabditis elegans or chemical inhibition in human cells and progeroid mice, results in increased resistance to various DNA-damage sources during development and aging.
- Arturo Bujarrabal-Dueso
- , Georg Sendtner
- & Björn Schumacher
Nature Structural & Molecular Biology, 1-14
Research
15 March 2023 | Open Access

Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells
- Miriana Cardano
- , Martina Magni
- & Laura Zannini
Cell Death & Disease 14, 197
Research
13 March 2023 | Open Access

Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Polymerase (POL) θ inhibitors display synthetic lethality in tumours with homologous recombination repair deficiency. Here, the authors demonstrate that POLθ inhibition with novobiocin activates the cGAS/STING pathway in BRCA-deficient cancers.
- Jeffrey Patterson-Fortin
- , Heta Jadhav
- & Geoffrey I. Shapiro
Nature Communications 14, 1390
Research | 13 March 2023

Revisiting mutagenesis at non-B DNA motifs in the human genome

The authors perform a computational analysis of mutagenesis at non-B DNA structures formed by repetitive sequences. Having removed confounding factors, they present a landscape of mutagenesis different than previously thought, in which mechanisms such as the formation of abnormal secondary structures, polymerase slippage and occasional takeover by error-prone polymerases play an important role within, but not surrounding, the motifs.
- R. J. McGinty
- & S. R. Sunyaev
Nature Structural & Molecular Biology, 1-8
Research
11 March 2023 | Open Access

Short-term molecular consequences of chromosome mis-segregation for genome stability

Chromosomal instability leads to aneuploidy, a state of karyotype imbalance. By inducing controlled chromosome mis-segregation, Santaguida and colleagues show that aneuploidy can also instigate chromosomal instability.
- Lorenza Garribba
- , Giuseppina De Feudis
- & Stefano Santaguida
Nature Communications 14, 1353
Research
09 March 2023 | Open Access

Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres

Here, the authors show that replication protein A (RPA) tends to self-assemble into dynamic condensates, in a manner that is stimulated by ssDNA and regulated by RPA2 phosphorylation. RPA condensates are functionally important for telomere clustering and RAD52-dependent telomere maintenance.
- Vincent Spegg
- , Andreas Panagopoulos
- & Matthias Altmeyer
Nature Structural & Molecular Biology, 1-12

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News and Comment

Correspondence
01 March 2023 | Open Access

Aspirin protects against genotoxicity by promoting genome repair
- Hui Jiang
- , Patrycja Swacha
- & Nelson O Gekara
Cell Research, 1-3
Correspondence
28 February 2023 | Open Access

Excess folic acid intake increases DNA de novo point mutations
- Xuanye Cao
- , Jianfeng Xu
- & Yunping Lei
Cell Discovery 9, 22
Comments & Opinion | 22 February 2023

DNA modifications walk a fine line between epigenetics and mutagenesis

Fleming and Burrows discuss similarities between a gene-regulating DNA modification and a mutagenic one, which share a common intermediate when removed through base excision repair.
- Aaron M. Fleming
- & Cynthia J. Burrows
Nature Reviews Molecular Cell Biology, 1-2
News & Views | 10 February 2023

Breaking the loop: RNA–DNA hybrids escape to the cytoplasm
- Dimitris Typas
Nature Structural & Molecular Biology 30, 134
News & Views | 30 January 2023

Topoisomerase II and etoposide — a tangled tale

Etoposide, a chemotherapeutic poison of type IIA eukaryotic topoisomerases (topo IIs), promotes topo II to compact DNA by trapping DNA loops, creates DNA double-strand breaks, causes topo II to resist relocation, and pauses the ability of topoisomerases to relax DNA supercoiling. Through these mechanisms, etoposide converts topo II into a roadblock to DNA processing.

Nature Chemical Biology, 1-2
Research Highlights | 19 January 2023

Too much DNA demethylation breaks post-mitotic cells
- Dimitris Typas
Nature Structural & Molecular Biology 30, 1

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DNA damage and repair articles from across Nature Portfolio

Latest Research and Reviews

The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities

Sex specific regulation of TSPY-Like 2 in the DNA damage response of cancer cells

Polymerase θ inhibition activates the cGAS-STING pathway and cooperates with immune checkpoint blockade in models of BRCA-deficient cancer

Revisiting mutagenesis at non-B DNA motifs in the human genome

Short-term molecular consequences of chromosome mis-segregation for genome stability

Phase separation properties of RPA combine high-affinity ssDNA binding with dynamic condensate functions at telomeres

News and Comment

Aspirin protects against genotoxicity by promoting genome repair

Excess folic acid intake increases DNA de novo point mutations

DNA modifications walk a fine line between epigenetics and mutagenesis

Breaking the loop: RNA–DNA hybrids escape to the cytoplasm

Topoisomerase II and etoposide — a tangled tale

Too much DNA demethylation breaks post-mitotic cells

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DNA damage and repair articles from across Nature Portfolio

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