Outlook |
Featured
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Nature Podcast |
Polio could be eradicated within 3 years — what happens then?
How to ensure polio doesn’t return after eradication, and the space explosion that’s baffling scientists.
- Benjamin Thompson
- & Shamini Bundell
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Article |
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease
A large fraction of patients with APS-1 and coeliac disease develop enamel dystrophy, characterized by the presence of autoantibodies against the enamel matrix, which are generated through the breakdown of either central (APS-1) or peripheral (coeliac) tolerance to a battery of ameloblast-sepecific proteins.
- Yael Gruper
- , Anette S. B. Wolff
- & Jakub Abramson
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World View |
Only 0.5% of neuroscience studies look at women’s health. Here’s how to change that
A new initiative challenges the severe neglect of women’s brain health from puberty through to pregnancy and menopause.
- Emily G. Jacobs
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News |
Massive genetic study finds genes linked to cannabis addiction
Data from more than one million genomes offer fresh insights into excessive cannabis use and its relationship to other diseases.
- Lilly Tozer
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News Explainer |
How wild monkeys ‘laundered’ for science could undermine research
Demand is fuelling an illegal trade. But smuggled monkeys carry diseases that can disrupt experiments and lead to unreliable data.
- Gemma Conroy
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Nature Podcast |
Massive study assesses benefits of lifestyle changes on diabetes risk
A large diabetes prevention programme in the UK is put to the test, with promising results.
- Benjamin Thompson
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News & Views |
Diabetes prevention programme put to the test
Causal evidence shows that referring people who are at risk of developing diabetes to a nationwide lifestyle-change programme can result in health improvements — but only if programme participation can be sustained.
- Edward W. Gregg
- & Naomi Holman
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Nature Podcast |
How to 3D print fully formed robots
Printing multi-material objects in a single run, and the effectiveness of lifestyle interventions for preventing type 2 diabetes.
- Benjamin Thompson
- & Shamini Bundell
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News |
Giant UK programme to lower people’s blood-sugar levels really works
One of the world’s biggest campaigns to prevent diabetes through behaviour change holds promise for public-health gains.
- Heidi Ledford
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Outlook |
Tropical diseases move north
As Earth warms, the creatures that spread neglected tropical diseases are gaining a foothold in Europe. Wealthy countries must prepare themselves for more cases.
- Claire Ainsworth
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Perspective |
The power and potential of mitochondria transfer
The mechanisms by which mitochondria are transferred between cells and how intercellular mitochondria transfer regulates physiological processes and disease pathogenesis are discussed.
- Nicholas Borcherding
- & Jonathan R. Brestoff
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Article
| Open Access
Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes
Single-cell transcriptomic and proteomic data from synovial tissue from individuals with rheumatoid arthritis classify patients into groups based on abundance of cell states that can provide insights into pathology and predict individual treatment responses.
- Fan Zhang
- , Anna Helena Jonsson
- & Soumya Raychaudhuri
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News |
Spinal implant helps man with advanced Parkinson’s to walk without falling
Electrical stimulation improved his mobility, although researchers say that a larger study is needed to assess the device.
- Emily Waltz
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News Feature |
Psychedelic treatments are speeding towards approval — but no one knows how they work
Many questions remain about the formerly taboo chemicals that are being used to treat trauma and depression.
- Sara Reardon
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News Explainer |
Dengue is spreading in Europe: how worried should we be?
The post-COVID travel boom combined with a warm summer have led to dengue outbreaks in Italy and France.
- Miryam Naddaf
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Nature Podcast |
Audio long read: Why BMI is flawed — and how to redefine obesity
Although body mass index is the main diagnostic test for obesity, it leaves out many factors that can affect how healthy someone is.
- McKenzie Prillaman
- & Benjamin Thompson
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News |
Dengue rates drop after release of modified mosquitoes in Colombia
Largest-ever deployment of Wolbachia-infected mosquitoes yields ‘encouraging’ results in three densely populated cities.
- Mariana Lenharo
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Article
| Open Access
An ON-type direction-selective ganglion cell in primate retina
Transcriptomic data and functional experiments on macaque retina are used to identify the ON-type direction-selective ganglion cells responsible for detecting moving images and initiating gaze-stabilization mechanisms.
- Anna Y. M. Wang
- , Manoj M. Kulkarni
- & Teresa Puthussery
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Comment |
Long COVID research risks losing momentum – we need a moonshot
Investing US$1 billion every year for the next ten years into long COVID research could improve the lives of millions and save trillions in economic costs.
- Lisa McCorkell
- & Michael J. Peluso
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News |
How the current bird flu strain evolved to be so deadly
Genetic changes to avian influenza viruses have led to spread among many wild species, creating an uncontrollable global outbreak.
- Miryam Naddaf
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Article |
The episodic resurgence of highly pathogenic avian influenza H5 virus
Recent resurgences of highly pathogenic avian influenza H5 viruses have different origins and virus ecologies as their epicentres shift and viruses evolve, with changes indicating increased adaptation among domestic birds.
- Ruopeng Xie
- , Kimberly M. Edwards
- & Vijaykrishna Dhanasekaran
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Article
| Open Access
The burden and dynamics of hospital-acquired SARS-CoV-2 in England
Data from acute hospitals in England are used to quantify hospital-acquired SARS-CoV-2 infections, evaluate likely pathways of spread and factors associated with heightened transmission risk, and explore the impact on community transmission.
- Ben S. Cooper
- , Stephanie Evans
- & Gwenan M. Knight
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News Explainer |
Anti-obesity drugs’ side effects: what we know so far
Recent studies evaluate risks associated with drugs such as Wegovy and Mounjaro.
- Mariana Lenharo
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Outlook |
Mental health: The invisible effects of neglected tropical diseases
The psychological burden of disability and stigma has been overlooked, to the detriment of those affected and their carers.
- Simon Makin
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Editorial |
Half a million children die of malaria every year. Finally we can change that
With two vaccines available, this killer disease could now be eliminated — but will the world pull together to make it happen?
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News Feature |
Why BMI is flawed — and how to redefine obesity
The main diagnostic test for obesity — the body mass index — accounts for only height and weight, leaving out a slew of factors that influence body fat and health.
- McKenzie Prillaman
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World View |
Nipah virus is deadly — but smart policy changes can help quell pandemic risk
Repeated outbreaks increase the risk of a Nipah strain emerging that is better at spreading.
- Thekkumkara Surendran Anish
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News |
Second malaria vaccine to win global approval is cheaper and easier to make
The World Health Organization has recommended a shot called R21 to prevent the disease in children.
- Miryam Naddaf
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News |
The brain cells linked to protection against dementia
People with an abundance of specific neurons are more likely to escape cognitive decline despite having signs of Alzheimer’s in their brains.
- Sara Reardon
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Article
| Open Access
The sex-specific factor SOA controls dosage compensation in Anopheles mosquitoes
A newly identified gene, sex chromosome activation (SOA), is a master regulator of dosage compensation in Anopheles gambiae.
- Agata Izabela Kalita
- , Eric Marois
- & Claudia Isabelle Keller Valsecchi
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Outlook |
The search for a connection between RSV and asthma
The consequences of respiratory syncytial virus infection sometimes linger for years — and scientists are trying to work out whether there’s a causal link.
- Sandy Ong
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Where I Work |
‘If I drop this, I’ll kill the queen’: how I launched a veterinary practice for bees
Elizabeth Hilborn is among just a handful of people in the United States who are medically trained to treat honey bees.
- Fern Reiss
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News |
Is depression lifting? AI that interprets brain waves has answers
A pattern of brain activity linked with recovery from severe depression could be used to improve therapies such as deep-brain stimulation
- Max Kozlov
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News |
Nipah virus outbreak: what scientists know so far
India is taking urgent steps to halt the transmission of a rare but deadly virus that spreads from bats to humans.
- Gemma Conroy
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Nature Podcast |
Why does cancer spread to the spine? Newly discovered stem cells might be the key
A stem cell vital for vertebral growth also drives spine metastases, and the use of MDMA in the treatment of PTSD.
- Benjamin Thompson
- & Shamini Bundell
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Article
| Open Access
Cingulate dynamics track depression recovery with deep brain stimulation
This study demonstrates how activity in the cingulate cortex tracks depression recovery, providing symptom relief using deep brain stimulation.
- Sankaraleengam Alagapan
- , Ki Sueng Choi
- & Christopher J. Rozell
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Article |
Reductive carboxylation epigenetically instructs T cell differentiation
Reductive carboxylation of glutamine by isocitrate dehydrogenase 2 (IDH2) has a role in determining the fate of T cells, and inhibiting this enzyme promotes the differentiation of memory T cells.
- Alison Jaccard
- , Tania Wyss
- & Mathias Wenes
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News |
AlphaFold tool pinpoints protein mutations that cause disease
Researchers have adapted the AI network to search for genetic changes linked to ill health.
- Ewen Callaway
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Book Review |
Geneticist J. Craig Venter: ‘I consider retirement tantamount to death’
The human genome ‘maverick’ talks sequencing the ocean, setting up a health-screening company after checking his own genes — and why he has no plans to stop.
- Heidi Ledford
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News |
First global survey reveals who is doing ‘gain of function’ research on pathogens and why
An analysis of the controversial work indicates that a one-size-fits-all regulation strategy will have consequences.
- Max Kozlov
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News |
Psychedelic drug MDMA moves closer to US approval following success in PTSD trial
Long-awaited trial data show drug is effective at treating post-traumatic stress disorder in a diversity of people.
- Sara Reardon
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News |
Life-changing cystic fibrosis treatment wins US$3-million Breakthrough Prize
Trio of scientists who developed the combination drug Trikafta are among the winners of five major awards in life sciences, physics and mathematics.
- Zeeya Merali
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Article
| Open Access
A foundation model for generalizable disease detection from retinal images
RETFound, a foundation model for retinal images that learns generalizable representations from unlabelled images, is trained on 1.6 million unlabelled images by self-supervised learning and then adapted to disease detection tasks with explicit labels.
- Yukun Zhou
- , Mark A. Chia
- & Pearse A. Keane
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Article
| Open Access
Causes and consequences of child growth faltering in low-resource settings
Analysis of data from 33 longitudinal cohorts from low- and middle-income countries indicates that conditions during pre-conception, pregnancy and the first few months of life are crucial in determining the risk of growth faltering in young children.
- Andrew Mertens
- , Jade Benjamin-Chung
- & Pablo Penataro Yori
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Article
| Open Access
Child wasting and concurrent stunting in low- and middle-income countries
An analysis of longitudinal cohort data across diverse populations suggests that the incidence of wasting between birth and 24 months is higher than previously thought, and highlights the role of seasonal factors that affect child growth.
- Andrew Mertens
- , Jade Benjamin-Chung
- & Pablo Penataro Yori
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Article
| Open Access
Early-childhood linear growth faltering in low- and middle-income countries
A pooled analysis of longitudinal studies in low- and middle-income countries identifies the typical age of onset of linear growth faltering and investigates recurrent faltering in early life.
- Jade Benjamin-Chung
- , Andrew Mertens
- & Pablo Penataro Yori
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World View |
A new model for public health in Africa can become a reality
As Africa emerges from the COVID pandemic, combating infectious diseases must be a priority — along with treating non-communicable and mental health conditions.
- Jean Kaseya
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