Diseases of the nervous system

Definition

Diseases of the nervous system refer to disorders that affect any part of the central nervous system (brain, spinal cord or cranial nerves) or peripheral nervous system.

Latest Research and Reviews

  • Research | | open

    Stress is recognized as risk factor for the development of type 2 diabetes. Here Balsevich et al. show that the stress responsive co-chaperone FKBP5 regulates glucose metabolism in mice by modulating AS160 phosphorylation, glucose transporter expression and muscle glucose uptake.

    • Georgia Balsevich
    • , Alexander S. Häusl
    • , Carola W. Meyer
    • , Stoyo Karamihalev
    • , Xixi Feng
    • , Max L. Pöhlmann
    • , Carine Dournes
    • , Andres Uribe-Marino
    • , Sara Santarelli
    • , Christiana Labermaier
    • , Kathrin Hafner
    • , Tianqi Mao
    • , Michaela Breitsamer
    • , Marily Theodoropoulou
    • , Christian Namendorf
    • , Manfred Uhr
    • , Marcelo Paez-Pereda
    • , Gerhard Winter
    • , Felix Hausch
    • , Alon Chen
    • , Matthias H. Tschöp
    • , Theo Rein
    • , Nils C. Gassen
    •  & Mathias V. Schmidt
  • Research | | open

    The Alzheimer protein Tau interacts with biological membranes, but the role of these interactions in regulating Tau function in health and disease remains unexplored. Here, the authors report on the discovery and characterization of neurotoxic oligomeric protein/phospholipid complexes.

    • Nadine Ait-Bouziad
    • , Guohua Lv
    • , Anne-Laure Mahul-Mellier
    • , Shifeng Xiao
    • , Gizem Zorludemir
    • , David Eliezer
    • , Thomas Walz
    •  & Hilal A. Lashuel
  • Research | | open

    Cholinergic neurons in the diagonal band of Broca degenerate early in Alzheimer’s disease. Here the authors show that in healthy mice, these cholinergic inputs innervate newborn neurons in the hippocampus, and that loss of this innervation in an Alzheimer’s disease model leads to impairments in spatial memory.

    • Houze Zhu
    • , Huanhuan Yan
    • , Na Tang
    • , Xinyan Li
    • , Pei Pang
    • , Hao Li
    • , Wenting Chen
    • , Yu Guo
    • , Shu Shu
    • , You Cai
    • , Lei Pei
    • , Dan Liu
    • , Min-Hua Luo
    • , Hengye Man
    • , Qing Tian
    • , Yangling Mu
    • , Ling-Qiang Zhu
    •  & Youming Lu
  • Research |

    Apicco and colleagues show that reducing TIA1 inhibits tau-mediated neurodegeneration and improves survival in a mouse model of tauopathy. This rescue occurs with a transition in tau aggregation from oligomeric to fibrillar forms of tau. These findings suggest a key role for RNA binding proteins in the pathophysiology of tau.

    • Daniel J. Apicco
    • , Peter E. A. Ash
    • , Brandon Maziuk
    • , Chelsey LeBlang
    • , Maria Medalla
    • , Ali Al Abdullatif
    • , Antonio Ferragud
    • , Emily Botelho
    • , Heather I. Ballance
    • , Uma Dhawan
    • , Samantha Boudeau
    • , Anna Lourdes Cruz
    • , Daniel Kashy
    • , Aria Wong
    • , Lisa R. Goldberg
    • , Neema Yazdani
    • , Cheng Zhang
    • , Choong Y. Ung
    • , Yorghos Tripodis
    • , Nicholas M. Kanaan
    • , Tsuneya Ikezu
    • , Pietro Cottone
    • , John Leszyk
    • , Hu Li
    • , Jennifer Luebke
    • , Camron D. Bryant
    •  & Benjamin Wolozin

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