Disease prevention

  • Article
    | Open Access

    Uninterrupted monitoring of pressure and temperature at skin interfaces can help to minimize the potential for pressure injuries in hospitalized or bedridden patients. Here, the authors introduce a soft, skin-mountable sensor that can continuously provide readings via antennas mounted under bedding, and demonstrate the functionality and robustness of the devices on patients.

    • Yong Suk Oh
    • , Jae-Hwan Kim
    •  & John A. Rogers
  • Article
    | Open Access

    Estimating the effectiveness of COVID-19 control measures requires large prospective data including symptoms and personal risk factors. Here, the authors used data from smartphone-based application and found that individual face mask use was associated with a 64% reduced risk of COVID-19 symptoms.

    • Sohee Kwon
    • , Amit D. Joshi
    •  & Andrew T. Chan
  • Article
    | Open Access

    Keratitis is the main cause of corneal blindness worldwide, but most vision loss caused by keratitis can be avoidable via early detection and treatment, which are challenging in resource-limited settings. Here, the authors develop a deep learning system for the automated classification of keratitis and other cornea abnormalities.

    • Zhongwen Li
    • , Jiewei Jiang
    •  & Wei Chen
  • Article
    | Open Access

    Non-pharmaceutical interventions (NPIs) implemented to interrupt COVID-19 transmission may also impact the spread of other infectious diseases. Here, the authors estimate that influenza activity in China and the United States reduced by up to 80% when NPIs were in place in the 2019–2020 season.

    • Luzhao Feng
    • , Ting Zhang
    •  & George F. Gao
  • Article
    | Open Access

    In response to COVID-19, many states have implemented social distancing orders, but the effect of these orders on population mobility has not been fully quantified. Here, the authors use data from the US to show that state-level social distancing orders substantially reduced mobility and limited the spread of disease.

    • Gregory A. Wellenius
    • , Swapnil Vispute
    •  & Evgeniy Gabrilovich
  • Article
    | Open Access

    Contact tracing is critical to controlling COVID-19, but most protocols only “forward-trace” to notify people who were recently exposed. Using a stochastic branching-process model, the authors show that “bidirectional” tracing to identify infector individuals and their other infectees robustly improves outbreak control.

    • William J. Bradshaw
    • , Ethan C. Alley
    •  & Kevin M. Esvelt
  • Article
    | Open Access

    Rap1, a member of the Ras family of small guanine triphosphatases, mediates lymphocyte adhesion to high endothelial venules. Here the authors show that depending on its activation status Rap1 plays a dual role in T cell adhesion and by regulating T cell homeostasis is involved in the protection from colitis.

    • Sayaka Ishihara
    • , Akihiko Nishikimi
    •  & Koko Katagiri
  • Article
    | Open Access

    Long-chain omega-3 polyunsaturated fatty acids are essential for neural development and lack of these fatty acids has been implicated in a number of mental health conditions. Here the authors report the longer-term efficacy of a randomized, double-blind, placebo-controlled clinical trial assessing the effects of fish oil capsules in individuals at ultrahigh risk for psychosis.

    • G. Paul Amminger
    • , Miriam R. Schäfer
    •  & Patrick D. McGorry
  • Article
    | Open Access

    Membrane repair of myocytes is important to prevent such disease as muscular dystrophy but the properties of this repair are not well characterised. In this study, vitamin E is shown to be important in the repair of myocyte cell membranes in cultured cells and in intact muscle.

    • Amber C. Howard
    • , Anna K. McNeil
    •  & Paul L. McNeil