Diagnostics articles within Nature Communications

Featured

• Article
  04 April 2024 | Open Access

  The CRISPR-Cas13a Gemini System for noncontiguous target RNA activation

  CRISPR-Cas13a based methods currently use contiguous target RNA activation, which only enables single-target detection or editing. Here the authors propose a noncontiguous target RNA activation approach which can provide rapid, simultaneous and sensitive detection of two RNAs in a single readout, as well as parallel dual transgene knockdown.

  • Hongrui Zhao
  • , Yan Sheng
  •  & Jiaming Hu

• Article
  20 November 2023 | Open Access

  Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation

  The SARS-CoV-2 pandemic highlighted our need for methods that allow rapid viral surveillance. Here, authors report a wireless, battery-free and wearable self-diagnosis platform that can continuously capture viral particles, diagnose infection status and evaluate symptom severity via breath and blow.

  • Hu Li
  • , Huarui Gong
  •  & Xinge Yu

• Article
  28 October 2023 | Open Access

  Near-infrared-II photoacoustic imaging and photo-triggered synergistic treatment of thrombosis via fibrin-specific homopolymer nanoparticles

  The near-infrared-II (NIR-II) window has shown great promise for in vivo imaging and therapy. Here, the authors integrate a homopolymer and thermo-sensitive nitric oxide prodrug into nanoparticles for long-wavelength NIR-II photoacoustic imaging and synergistic treatment in preclinical thrombosis models.

  • Jianwen Song
  • , Xiaoying Kang
  •  & Ji Qi

• Article
  17 July 2023 | Open Access

  Multiplexed RNA profiling by regenerative catalysis enables blood-based subtyping of brain tumors

  Current methods to subtype brain tumors rely on invasive biopsies. Here, the authors develop a digital platform to regeneratively convert and catalytically enhance signals from rare circulating RNAs for blood-based characterization of brain tumors.

  • Yan Zhang
  • , Chi Yan Wong
  •  & Huilin Shao

• Article
  17 May 2023 | Open Access

  High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays

  A peptide was developed that binds to calprotectin, a marker of major inflammatory disorders, and found to be suited for diagnostic tests. The use of synthetic peptides in assays is of great interest due to their high precision, robustness and low price.

  • Cristina Díaz-Perlas
  • , Benjamin Ricken
  •  & Christian Heinis

• Article
  17 March 2023 | Open Access

  CRISPR-induced DNA reorganization for multiplexed nucleic acid detection

  Nucleic acid sensing involving CRISPR technologies is powerful but has certain limitations, such as PAM sequence requirements and limited multiplexing. Here, authors report a CRISPR-based barcoding technology which enables multiple outputs from any target sequence, based on cis- and trans-cleavage.

  • Margot Karlikow
  • , Evan Amalfitano
  •  & Keith Pardee

• Article
  24 February 2023 | Open Access

  Molecular imaging of liver inflammation using an anti-VCAM-1 nanobody

  Here, the authors present a noninvasive tool to detect liver inflammation using nuclear imaging, as an alternative to biopsy. The prove the diagnostic power of this tool to detect liver inflammation in preclinical models of chronic liver disease.

  • Maxime Nachit
  • , Christopher Montemagno
  •  & Pascale Perret

• Article
  10 November 2016 | Open Access

  Theranostic barcoded nanoparticles for personalized cancer medicine

  Determining the most effective treatment for each cancer patient is a key challenge in cancer therapy. In this article, the authors show, in a mouse model of breast cancer, that DNA barcoded nanoparticles can be used for pre-screening the efficacy of anticancer drugs.

  • Zvi Yaari
  • , Dana da Silva
  •  & Avi Schroeder

• Article
  13 March 2015 | Open Access

  Sensitive β-galactosidase-targeting fluorescence probe for visualizing small peritoneal metastatic tumours in vivo

  Surgical removal of the metastases remains a life-extending approach to ovarian cancer, but the nodules are difficult to detect. Here the authors show that a new cell-permeable probe for β-galactosidase can sensitively and specifically detect peritoneal metastases in mouse models of ovarian cancer.

  • Daisuke Asanuma
  • , Masayo Sakabe
  •  & Yasuteru Urano

• Article | 23 September 2014

  Rapid in vivo detection of isoniazid-sensitive Mycobacterium tuberculosis by breath test

  There is an urgent need for rapid point-of-care tools for tuberculosis diagnosis and antibiotic sensitivity analysis. Here, the authors describe a breath test that, within minutes, detects isoniazid-susceptible Mycobacterium tuberculosisin infected animals.

  • Seong W. Choi
  • , Mamoudou Maiga
  •  & Graham S. Timmins