Diabetic nephropathy

Diabetic nephropathy is a progressive kidney disease associated with diabetes mellitus – type 1 and type 2 – affecting kidney glomeruli, arterioles, tubules and the interstitium. Clinical features include macroalbuminuria and a reduction in glomerular filtration rate that may lead to end-stage renal disease, requiring dialysis or kidney transplantation.

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  • Research | | open

    Sphingomyelin phosphodiesterase acid-like 3b (SMPDL3b) is a lipid raft enzyme known to affect membrane lipid composition. Here, Mitrofanova et al. show that increased expression of SMPDL3b in diabetes impairs insulin signaling and ceramide-1-phosphate (C1P) availability in podocytes, and that C1P supplementation protects mice from diabetic kidney disease.

    • A. Mitrofanova
    • , S. K. Mallela
    • , G. M. Ducasa
    • , T. H. Yoo
    • , E. Rosenfeld-Gur
    • , I. D. Zelnik
    • , J. Molina
    • , J. Varona Santos
    • , M. Ge
    • , A. Sloan
    • , J. J. Kim
    • , C. Pedigo
    • , J. Bryn
    • , I. Volosenco
    • , C. Faul
    • , Y. H. Zeidan
    • , C. Garcia Hernandez
    • , A. J. Mendez
    • , I. Leibiger
    • , G. W. Burke
    • , A. H. Futerman
    • , L. Barisoni
    • , Y. Ishimoto
    • , R. Inagi
    • , S. Merscher
    •  & A. Fornoni
  • Research | | open

    Patients with diabetes commonly develop diabetic kidney disease (DKD). Here Gluck et al. identify a set of probes differentially methylated in renal samples from patients with DKD, and find that inclusion of these methylation probes improves current prediction models of renal function decline.

    • Caroline Gluck
    • , Chengxiang Qiu
    • , Sang Youb Han
    • , Matthew Palmer
    • , Jihwan Park
    • , Yi-An Ko
    • , Yuting Guan
    • , Xin Sheng
    • , Robert L. Hanson
    • , Jing Huang
    • , Yong Chen
    • , Ae Seo Deok Park
    • , Maria Concepcion Izquierdo
    • , Ioannis Mantzaris
    • , Amit Verma
    • , James Pullman
    • , Hongzhe Li
    •  & Katalin Susztak
  • Research | | open

    Diabetes is a major cause of kidney disease. Here Kikuchi et al. show that phenol sulfate, a gut microbiota-derived metabolite, is increased in diabetic kidney disease and contributes to the pathology by promoting kidney injury, suggesting phenyl sulfate could be used a marker and therapeutic target for the treatment of diabetic kidney disease.

    • Koichi Kikuchi
    • , Daisuke Saigusa
    • , Yoshitomi Kanemitsu
    • , Yotaro Matsumoto
    • , Paxton Thanai
    • , Naoto Suzuki
    • , Koki Mise
    • , Hiroaki Yamaguchi
    • , Tomohiro Nakamura
    • , Kei Asaji
    • , Chikahisa Mukawa
    • , Hiroki Tsukamoto
    • , Toshihiro Sato
    • , Yoshitsugu Oikawa
    • , Tomoyuki Iwasaki
    • , Yuji Oe
    • , Tomoya Tsukimi
    • , Noriko N. Fukuda
    • , Hsin-Jung HO
    • , Fumika Nanto-Hara
    • , Jiro Ogura
    • , Ritsumi Saito
    • , Shizuko Nagao
    • , Yusuke Ohsaki
    • , Satoshi Shimada
    • , Takehiro Suzuki
    • , Takafumi Toyohara
    • , Eikan Mishima
    • , Hisato Shima
    • , Yasutoshi Akiyama
    • , Yukako Akiyama
    • , Mariko Ichijo
    • , Tetsuro Matsuhashi
    • , Akihiro Matsuo
    • , Yoshiaki Ogata
    • , Ching-Chin Yang
    • , Chitose Suzuki
    • , Matthew C. Breeggemann
    • , Jurgen Heymann
    • , Miho Shimizu
    • , Susumu Ogawa
    • , Nobuyuki Takahashi
    • , Takashi Suzuki
    • , Yuji Owada
    • , Shigeo Kure
    • , Nariyasu Mano
    • , Tomoyoshi Soga
    • , Takashi Wada
    • , Jeffrey B. Kopp
    • , Shinji Fukuda
    • , Atsushi Hozawa
    • , Masayuki Yamamoto
    • , Sadayoshi Ito
    • , Jun Wada
    • , Yoshihisa Tomioka
    •  & Takaaki Abe

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