Developmental neurogenesis

Developmental neurogenesis is the formation of functional, mature neurons from neural stem cells during development of an organism. Understanding developmental neurogenesis helps in the understanding of congenital neurological disorders.

Latest Research and Reviews

  • Research
    | Open Access

    During embryonic development, neural progenitor cells undergo numerous cell divisions. Here, the authors show that ABHD4-mediated developmental anoikis distinguishes the physiological delamination and the pathological detachment of progenitor cells with relevance to fetal alcohol-induced apoptosis.

    • Zsófia I. László
    • , Zsolt Lele
    • , Miklós Zöldi
    • , Vivien Miczán
    • , Fruzsina Mógor
    • , Gabriel M. Simon
    • , Ken Mackie
    • , Imre Kacskovics
    • , Benjamin F. Cravatt
    •  & István Katona
  • Research
    | Open Access

    The diversity of primary sensory neurons and how fate choice is determined is unclear. Here, the authors use single cell RNA sequencing analysis of early murine somatosensory neurons to show that sensory neuron diversity is achieved by a transition through a bi-potential intermediate state.

    • Louis Faure
    • , Yiqiao Wang
    • , Maria Eleni Kastriti
    • , Paula Fontanet
    • , Kylie K. Y. Cheung
    • , Charles Petitpré
    • , Haohao Wu
    • , Lynn Linyu Sun
    • , Karen Runge
    • , Laura Croci
    • , Mark A. Landy
    • , Helen C. Lai
    • , Gian Giacomo Consalez
    • , Antoine de Chevigny
    • , François Lallemend
    • , Igor Adameyko
    •  & Saida Hadjab
  • Research
    | Open Access

    Myelination by Schwann cells (SC) in the peripheral nervous system is essential for motor function, and dysregulation of SC myelination can lead to various neuropathies. Here the authors describe a critical role of CCCTC-binding factor (CTCF)-dependent chromatin reorganization in peripheral myelination and myelin regeneration after injury.

    • Jincheng Wang
    • , Jiajia Wang
    • , Lijun Yang
    • , Chuntao Zhao
    • , Laiman Natalie Wu
    • , Lingli Xu
    • , Feng Zhang
    • , Qinjie Weng
    • , Michael Wegner
    •  & Q. Richard Lu
  • Research
    | Open Access

    Columns are the functional and morphological unit of the brain, but how neurons assemble into this structure was unclear. Here, the authors show that Dscam gene rewires neurons that derive from the same stem cell to establish columns through the process of lineage-dependent repulsion.

    • Chuyan Liu
    • , Olena Trush
    • , Xujun Han
    • , Miaoxing Wang
    • , Rie Takayama
    • , Tetsuo Yasugi
    • , Takashi Hayashi
    •  & Makoto Sato
  • Research
    | Open Access

    Polycomb repressive complex 2 (PRC2) methylates H3K27 and suppresses RNA polymerase II transcription by promoting a closed chromatin. Here the authors identify the transcription factor Ybx1 as an interactor that regulates the binding of PRC2 to chromatin and H3K27 methylation to promote the genetic programs underlying neural lineages and neural progenitor self-renewal–differentiation choices.

    • Myron K. Evans
    • , Yurika Matsui
    • , Beisi Xu
    • , Catherine Willis
    • , Jennifer Loome
    • , Luis Milburn
    • , Yiping Fan
    • , Vishwajeeth Pagala
    •  & Jamy C. Peng
  • Research
    | Open Access

    The hypothalamus performs a wide range of vital physiological functions, including growth and reproductive behaviors, and circadian rhythms. The authors identify and characterize hypothalamic radial glial and hypothalamic mantle zone radial glial cells as the neural progenitors in the hypothalamus.

    • Xin Zhou
    • , Suijuan Zhong
    • , Honghai Peng
    • , Jing Liu
    • , Wenyu Ding
    • , Le Sun
    • , Qiang Ma
    • , Zeyuan Liu
    • , Ruiguo Chen
    • , Qian Wu
    •  & Xiaoqun Wang

News and Comment