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Depression refers to a state of low mood that can be accompanied with loss of interest in activities that the individual normally perceived as pleasurable, altered appetite and sleep/wake balance. Its severe form, major depression is classified as a mood disorder.
Using stereotactic electroencephalography, the authors identified differential amygdala activation in response to emotional faces in participants with treatment-resistant depression compared with non-depressed participants with epilepsy, suggesting possible deep brain stimulation targets.
Wastewater analysis can quantify the pharmaceuticals used to treat mental health disorders, providing data for policy development. This Comment highlights the potential of such wastewater-based epidemiology to enhance the estimation of treated mental health disorders at the community level.
Increased levels of matrix metalloproteinase 8, expressed by circulating myeloid cells, may have a role in stress-induced changes in social behaviour in mice.
Combining accelerometry, electronic diaries and neuroimaging, we found that physical activity is reproducibly linked to better wellbeing in people lacking social contact in everyday life, especially in people at neural and psychological risk of affective disorders.
