Cytotoxic T cells

Cytotoxic T cells are CD8-postive T cells that are specialized for the direct killing of cells that are infected (particularly with viruses), cancerous or damaged in other ways. They express the glycoprotein CD8, as well as T cell receptors that recognize antigenic peptides presented by MHC class I molecules. There are two effector phenotypes: TC1 and TC2.

Latest Research and Reviews

  • Research
    | Open Access

    The inhibitory receptors PD-1, Tim-3 and Lag-3 act as negative feedback regulators of T cell responses. Here the authors improve CAR T cell antitumor efficacy by triple knockdown of these receptors, show it requires CD56, and correlate CD56-mediated homophilic cell interactions with CAR T cell efficacy.

    • Fan Zou
    • , Lijuan Lu
    • , Jun Liu
    • , Baijin Xia
    • , Wanying Zhang
    • , Qifei Hu
    • , Weiwei Liu
    • , Yiwen Zhang
    • , Yingtong Lin
    • , Shuliang Jing
    • , Mei Huang
    • , Bifen Huang
    • , Bingfeng Liu
    •  & Hui Zhang
  • Research
    | Open Access

    Lymphocytes are considered one of the most radiosensitive cell types in the body. Here the authors show that unlike circulating lymphocytes, tumor-infiltrating T cells survive therapeutic doses of irradiation, remaining functional and contributing to radiotherapy induced anti-tumor immunity.

    • Ainhoa Arina
    • , Michael Beckett
    • , Christian Fernandez
    • , Wenxin Zheng
    • , Sean Pitroda
    • , Steven J. Chmura
    • , Jason J. Luke
    • , Martin Forde
    • , Yuzhu Hou
    • , Byron Burnette
    • , Helena Mauceri
    • , Israel Lowy
    • , Tasha Sims
    • , Nikolai Khodarev
    • , Yang-Xin Fu
    •  & Ralph R. Weichselbaum
  • Research
    | Open Access

    Severe cutaneous adverse reactions (SCAR) is a T cell-mediated, potentially lethal drug hypersensitivity (DH). Here, the authors identify a carbamazepine-specific TCR common among patients with carbamazepine-induced SCAR that confers SCAR-like pathology in mice upon carbamazepine exposure, thereby implicating specific TCRs in DH etiology.

    • Ren-You Pan
    • , Mu-Tzu Chu
    • , Chuang-Wei Wang
    • , Yun-Shien Lee
    • , Francois Lemonnier
    • , Aaron W. Michels
    • , Ryan Schutte
    • , David A. Ostrov
    • , Chun-Bing Chen
    • , Elizabeth Jane Phillips
    • , Simon Alexander Mallal
    • , Maja Mockenhaupt
    • , Teresa Bellón
    • , Wichittra Tassaneeyakul
    • , Katie D. White
    • , Jean-Claude Roujeau
    • , Wen-Hung Chung
    •  & Shuen-Iu Hung
  • Research
    | Open Access

    CTL responses are critical in protection against pathogens. Here, using mass spectrometry and flow cytometry, the authors characterize the kinetics of influenza A virus class I MHC epitopes cross-presented in professional antigen presenting cells and identify new epitopes that elicit T cell responses in infected mice.

    • Ting Wu
    • , Jing Guan
    • , Andreas Handel
    • , David C. Tscharke
    • , John Sidney
    • , Alessandro Sette
    • , Linda M. Wakim
    • , Xavier Y. X. Sng
    • , Paul G. Thomas
    • , Nathan P. Croft
    • , Anthony W. Purcell
    •  & Nicole L. La Gruta
  • Research
    | Open Access

    Viral rebound following discontinuation of antiretroviral therapy (ART) is a major obstacle for HIV cure. Here, the authors show that adoptive cellular therapy using autologous Env-specific T cells augmented by therapeutic vaccination can control viral rebound after ART interruption in a SHIV macaque model.

    • Jin Fan
    • , Hua Liang
    • , Xiaolin Ji
    • , Shuo Wang
    • , Jing Xue
    • , Dan Li
    • , Hong Peng
    • , Chuan Qin
    • , Cassian Yee
    •  & Yiming Shao
  • Research |

    Exhausted cytotoxic T lymphocytes (CTLs) express the receptor PD-1 as a key signature. Haining and colleagues show that there are different ‘depths’ of exhaustion with a subset of exhausted CTLs that retain polyfunctionality and are responsive to PD-1 blockade.

    • Brian C. Miller
    • , Debattama R. Sen
    • , Rose Al Abosy
    • , Kevin Bi
    • , Yamini V. Virkud
    • , Martin W. LaFleur
    • , Kathleen B. Yates
    • , Ana Lako
    • , Kristen Felt
    • , Girish S. Naik
    • , Michael Manos
    • , Evisa Gjini
    • , Juhi R. Kuchroo
    • , Jeffrey J. Ishizuka
    • , Jenna L. Collier
    • , Gabriel K. Griffin
    • , Seth Maleri
    • , Dawn E. Comstock
    • , Sarah A. Weiss
    • , Flavian D. Brown
    • , Arpit Panda
    • , Margaret D. Zimmer
    • , Robert T. Manguso
    • , F. Stephen Hodi
    • , Scott J. Rodig
    • , Arlene H. Sharpe
    •  & W. Nicholas Haining
    Nature Immunology 20, 326-336

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