Cytoskeletal proteins

Cytoskeletal proteins are proteins that make up the cytoskeleton, flagella or cilia of cells. Generally, cytoskeletal proteins are polymers, and include tubulin (the protein component of microtubules), actin (the component of microfilaments) and lamin (the component of intermediate filaments).

Latest Research and Reviews

News and Comment

  • Research Highlights |

    Metabolic labeling enables researchers to spatiotemporally assess nascent protein deposition in 3D hydrogels and then study how nascent proteins influence cell behaviors.

    • Lei Tang
    Nature Methods 16, 358
  • Research Highlights |

    A recent study makes the surprising observation that autophagosomes can still form in the absence of the core conjugation machinery. Furthermore, while such autophagosomes can fuse with lysosomes, their degradation is delayed, and this is associated with delayed destruction of the inner autophagosomal double membrane, highlighting a new role for proteins thought to act exclusively in the formation of autophagosomes in late stages of the autophagic itinerary within autolysosomes.

    • Maurizio Renna
    •  & David C Rubinsztein
    Cell Research 27, 5-6
  • Research Highlights |

    The autophagy-related process LC3-Associated Phagocytosis, or LAP, is known to control the degradation of engulfed cells and microorganisms. Now Martinez et al. discover that LAP controls immune responses to dying cells and its inhibition leads to development of Systemic Lupus Erythematosus-like disease.

    • Urmi Bandyopadhyay
    •  & Michael Overholtzer
    Cell Research 26, 865-866
  • News & Views |

    Dynactin is an essential cofactor for the microtubule-based motor cytoplasmic dynein. Two recent papers report structures obtained by cryo-EM of dynactin, the dynein–dynactin complex and dynein–dynactin bound to its track, the microtubule.

    • Samara L Reck-Peterson