Cytological techniques articles from across Nature Portfolio

A protocol for the generation of induced blastoids, an in vitro integrated model of the human blastocyst derived via somatic reprogramming. This model overcomes restrictions associated with the use of human blastocysts in embryology research.

Characterising interactions between proteins that are large and poorly soluble remains challenging. Here, the authors describe ReLo, a rapid and versatile eukaryotic cell culture-based method for detecting and studying direct interactions between structurally complex proteins.

The field of spatial omics is developing rapidly, with a potentially transformative effect across many areas of biology. Nature Genetics invites authors to submit papers that use these techniques to answer questions of broad interest to researchers working in genetics and genomics.

A new study combining experimental treatments of human blood cells from thousands of individuals with flow-cytometry-based phenotyping and then genome-wide association analyses identifies genetic loci associated with non-resting cell states. Integrating the results with disease association signals yields insights into the underlying biology.

Barcoding cells with microparticles that emit near-infrared laser light enables the use of flow cytometry to track the dynamics of single cells by using more markers and fewer colours.

DARLIN enables the generation of a massive diversity of barcodes for in vivo lineage tracing and the combination with single-cell multi-omics measurements.

New traceability and reporting standards aim to improve transparency in stem cell research.