Cytogenetics articles within Nature Communications

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  • Article
    | Open Access

    The centromere is required for the segregation of chromosomes. Here, the authors report the organization and dynamic of holocentric chromosomes, each containing 7 to 11 evenly spaced megabase-sized centromere-specific histone H3-positive units.

    • Yi-Tzu Kuo
    • , Amanda Souza Câmara
    •  & Andreas Houben

  • Article
    | Open Access

    The effect of sequence polymorphisms on recombination is not fully understood. Here, the authors develop the seed-typing method to map crossovers (COs) by sequencing and show that COs occur preferentially within polymorphic hotspots and that this effect depends on the mismatch repair gene MSH2 in Arabidopsis.

    • Maja Szymanska-Lejman
    • , Wojciech Dziegielewski
    •  & Piotr A. Ziolkowski

  • Article
    | Open Access

    During meiosis, the number and distribution of crossovers (COs) are tightly controlled, but the mechanistic basis of this control is unclear. Here, by combining experimental data and mathematical modeling, the study advocates a CO patterning model via coarsening through the diffusion of HEI10 along the synaptonemal complex.

    • Stéphanie Durand
    • , Qichao Lian
    •  & Raphael Mercier

  • Article
    | Open Access

    The frequency of recombination varies along chromosomes and highly correlates with sequence divergence. Here, the authors show that polymorphisms are not a major determinant of the megabase-scale recombination landscape in Arabidopsis, which is rather determined by chromatin accessibility and DNA methylation.

    • Qichao Lian
    • , Victor Solier
    •  & Raphael Mercier

  • Article
    | Open Access

    The FANCM helicase functions in limiting crossovers (COs) by unwinding inter-homolog repair intermediates. Here, the authors generate null mutants of fancm in tetraploid and hexaploid wheat and show that FANCM promotes class I interfering COs and suppresses class II noninterfering COs in wheat meiosis.

    • Stuart D. Desjardins
    • , James Simmonds
    •  & James D. Higgins

  • Article
    | Open Access

    Crossover numbers and positions are tightly controlled but the mechanism involved is still obscure. Here, the authors, using quantitative super-resolution cytogenetics and mathematical modelling, show that diffusion mediated coarsening of HEI10, an E3-ligase domain containing protein, may explain meiotic crossover positioning in Arabidopsis.

    • Chris Morgan
    • , John A. Fozard
    •  & Martin Howard

  • Article
    | Open Access

    B chromosomes are supernumerary chromosomes exhibiting dramatic differences between different organs in same species. Here, the authors show programmed B chromosome elimination in goatgrass starts at the onset of embryo differentiation by nondisjunction of chromatids, anaphase lagging, and ends with the degradation of micronucleated DNA.

    • Alevtina Ruban
    • , Thomas Schmutzer
    •  & Andreas Houben

  • Article
    | Open Access

    Meiotic crossovers (COs) are essential for proper chromosome segregation and generating novel combinations of alleles. Here, the authors develop haplotype-specific oligos on maize chromosome 10 for fluorescence in situ hybridization and analyze CO patterns in an intermated recombinant population derived from B73 and Mo17.

    • Lívia do Vale Martins
    • , Fan Yu
    •  & Jiming Jiang

  • Article
    | Open Access

    While X-chromosome gene content tends to be conserved, Y-chromosome evolution is dynamic and difficult to reconstruct. Here, Mahajan and Bachtrog use a subtraction pipeline to identify Y-linked genes in 22 Diptera species, revealing patterns of Y-chromosome gene-content evolution.

    • Shivani Mahajan
    •  & Doris Bachtrog

  • Article
    | Open Access

    The X-chromosome linked long non-coding RNA, Xist, is a master regulator of the X inactivation. Here, the authors report that XistAR, an Xist anti-sense long non-coding RNA encoded within the mouse Xist gene and transcribed only from the inactive X chromosome, regulates Xistexpression.

    • Mrinal K. Sarkar
    • , Srimonta Gayen
    •  & Sundeep Kalantry

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