Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer).
The cortex refers to the outermost layer of the cerebral hemispheres or cerebrum. The cerebral cortex in humans is folded into gyri and consists of six horizontal layers of neurons, with distinct connections among the layers and neuronal subtypes of cells.
Advances in multi-neuron recordings and optogenetic manipulation have resulted in an interrogation of the function of specific cortical cell types in auditory cortex during sound processing. Here, the authors review this literature and discuss the merits of integrating computational approaches from dynamic network science.
Perception can be explained by predictive coding, but it is unclear how this theory applies at the single-neuron level. Here, authors describe how auditory patterns are encoded and detected by single neurons along the auditory pathway, demonstrating that prediction error exists in single auditory neurons.
A combination of computational modeling, neuroimaging and a causal manipulation of brain activity in humans reveals how the brain represents beliefs about how our choices will affect those of others we interact with.
A new study in mice shows that memory engram cells associated with long-term memories form in the prefrontal cortex early during learning in a contextual fear conditioning paradigm and reveals details of the circuitry involved in long-term memory consolidation.
Connectivity patterns of neocortex exhibit several odd properties: for example, most neighboring excitatory neurons do not connect, which seems curiously wasteful. Brunel's elegant theoretical treatment reveals how optimal information storage can naturally impose these peculiar properties.