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| Open AccessA role for spindles in the onset of rapid eye movement sleep
During NREM sleep, spindles emerge from thalamocortical interactions. Here the authors carry out multisite thalamic and cortical recordings in freely behaving mice, to investigate the role of other non-classical thalamic sites in sleep spindle generation.
- Mojtaba Bandarabadi
- , Carolina Gutierrez Herrera
- & Antoine R. Adamantidis
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Article
| Open AccessLanguage prediction mechanisms in human auditory cortex
The human brain fluently parses continuous speech during perception and production. Using direct brain recordings coupled with stimulation, the authors identify separable substrates underlying two distinct predictive mechanisms of “when” in Heschl’s gyrus and “what” in planum temporale.
- K. J. Forseth
- , G. Hickok
- & N. Tandon
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Article
| Open AccessSingle-neuron representation of learned complex sounds in the auditory cortex
Using a combination of two-photon imaging and single-cell electrophysiology, the authors discover that associative learning induces the emergence of a unique subset of neurons in the auditory cortex, exhibiting high-rate bursting responses to the learned complex sounds but not to any of the constituents.
- Meng Wang
- , Xiang Liao
- & Xiaowei Chen
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Article
| Open AccessGlobal reward state affects learning and activity in raphe nucleus and anterior insula in monkeys
Wittmann and colleagues show that not only single outcome events but also the global reward state (GRS) impact learning in macaques; low GRS drives explorative choices. Analyses of macaque BOLD signal reveals that GRS impacts activity in the anterior insula as well as the dorsal raphe nucleus.
- Marco K. Wittmann
- , Elsa Fouragnan
- & Matthew F. S. Rushworth
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Article
| Open AccessFeature-specific neural reactivation during episodic memory
Memory recollection involves reactivation of neural activity that occurred during the recalled experience. Here, the authors show that neural reactivation can be decomposed into visual-semantic features, is widely synchronized throughout the brain, and predicts memory vividness and accuracy.
- Michael B. Bone
- , Fahad Ahmad
- & Bradley R. Buchsbaum
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Article
| Open AccessOlfactory memory representations are stored in the anterior olfactory nucleus
Odours are powerful stimuli used by most organisms to guide behaviour. Here, the authors identify populations of neurons within the anterior olfactory nucleus (AON) which are necessary and sufficient for the behavioural expression of odour memory.
- Afif J. Aqrabawi
- & Jun Chul Kim
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Article
| Open AccessStimulus dependent transformations between synaptic and spiking receptive fields in auditory cortex
The authors compare receptive fields and nonlinearities of synaptic inputs, membrane potentials, and spiking activity in the auditory cortex for broadband stimuli revealing distinct differences, which lead to an increase in feature selectivity from neuron input to output. Frequency selectivity is distinctly higher for spectrotemporal receptive fields (STRFs) than for tonal receptive fields (TRFs).
- Kyunghee X. Kim
- , Craig A. Atencio
- & Christoph E. Schreiner
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Article
| Open AccessNeural circuits underlying auditory contrast gain control and their perceptual implications
Auditory contrast gain control helps us perceive sounds as constant despite changes in the environment or background noise. Here, the authors show that neurons in the auditory thalamus and midbrain of mice display independent contrast gain control, not just the cortex as previously thought.
- Michael Lohse
- , Victoria M. Bajo
- & Ben D. B. Willmore
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Article
| Open AccessCerebral oxygenation during locomotion is modulated by respiration
Understanding mechanisms of cerebral oxygen regulation is critical for healthy brain function. Here the authors show that respiration is a key modulator of cerebral oxygenation, which will be helpful in better resolving neurally-generated functional brain imaging signals, such as BOLD fMRI.
- Qingguang Zhang
- , Morgane Roche
- & Patrick J. Drew
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Article
| Open AccessMultiple associative structures created by reinforcement and incidental statistical learning mechanisms
Associative learning occurs through reinforcement mechanisms as well as incidentally through experience of statistical relationships. Here, the authors report that these two learning processes are associated with specialized anatomical regions that operate at different time scales.
- Miriam C. Klein-Flügge
- , Marco K. Wittmann
- & Matthew F. S. Rushworth
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Article
| Open AccessContributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty
The degree of subjective confidence in deciding based on ambiguous sensory cues facilitates learning. Here, the authors report distinct functions of the basolateral amygdala and anterior cingulate cortex on implicit confidence judgements as well as flexible learning under uncertain conditions in rats.
- A. Stolyarova
- , M. Rakhshan
- & A. Izquierdo
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Article
| Open AccessHighly structured, partner-sex- and subject-sex-dependent cortical responses during social facial touch
Touch is an important sensory modality during social encounters. Here the authors report that during naturalistic social encounters in rats, the cortical activity in widespread areas at the level of single neurons is modulated by sociosexual characteristics such as the subject and partner sex.
- Christian L. Ebbesen
- , Evgeny Bobrov
- & Michael Brecht
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Article
| Open AccessSensory representations in the striatum provide a temporal reference for learning and executing motor habits
The authors combine anatomical mapping, electrophysiological recordings, lesions, and pharmacological and optogenetic manipulations in rats to examine the role of forelimb somatosensory flow in the dorsolateral striatum in the learning and execution of motor habits.
- Ana E. Hidalgo-Balbuena
- , Annie Y. Luma
- & Pavel E. Rueda-Orozco
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Article
| Open AccessAnti-relapse neurons in the infralimbic cortex of rats drive relapse-suppression by drug omission cues
Drug addiction is a chronic disorder and many sufferers experience relapses even after a period of successful abstinence. Here, the authors reveal a subset of neurons in the rat infralimbic cortex that suppresses relapse into cocaine or alcohol use by responding to drug-omission cues.
- Amanda Laque
- , Genna L. De Ness
- & Nobuyoshi Suto
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Article
| Open AccessCortical reliability amid noise and chaos
Whether cortical neurons can fire reliable spikes amid cellular noise and chaotic network dynamics remains debated. Here the authors simulate a detailed neocortical microcircuit model and show that noisy and chaotic cortical network dynamics are compatible with stimulus-evoked, millisecond spike-time reliability.
- Max Nolte
- , Michael W. Reimann
- & Eilif B. Muller
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Article
| Open AccessThe rough sound of salience enhances aversion through neural synchronisation
Certain sounds are especially attention-grabbing and often unpleasant as well. Here, the authors show that fast but perceptible amplitude modulations in the ‘roughness range' (30–150 Hz) are temporally salient and synchronise not just brain auditory networks but also salience-related networks.
- Luc H. Arnal
- , Andreas Kleinschmidt
- & Pierre Mégevand
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Article
| Open AccessVentral midbrain stimulation induces perceptual learning and cortical plasticity in primates
Practice can improve the perception of stimuli used to achieve a task (perceptual learning). Here, the authors show in monkeys that perceptual learning can be produced even for irrelevant stimuli if the stimuli are paired with stimulation of a dopaminergic centre, the ventral tegmental area (VTA).
- John T. Arsenault
- & Wim Vanduffel
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Article
| Open AccessAutomatic and feature-specific prediction-related neural activity in the human auditory system
After listening to a predictable sequence of sounds, we can anticipate and predict the next sound in the sequence. Here, the authors show that during expectation of a sound, the brain generates neural activity matching that which is produced by actually hearing the same sound.
- Gianpaolo Demarchi
- , Gaëtan Sanchez
- & Nathan Weisz
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Article
| Open AccessNeurons in primary auditory cortex represent sound source location in a cue-invariant manner
The brain's auditory cortex is involved not just in detection of sounds, but also in localizing them. Here, the authors show that neurons in ferret primary auditory cortex (A1) encode the location of sound sources, as opposed to merely reflecting spatial cues.
- Katherine C. Wood
- , Stephen M. Town
- & Jennifer K. Bizley
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Article
| Open AccessCircuit asymmetries underlie functional lateralization in the mouse auditory cortex
The left hemisphere of the brain is especially involved in processing social vocalizations and (in humans) language, but the mechanisms of this lateralization of function are unclear. Here, the authors compared left and right auditory cortex in mice and show lateralized, experience-dependent circuit-motifs.
- Robert B. Levy
- , Tiemo Marquarding
- & Hysell V. Oviedo
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Article
| Open AccessAdaptation of the human auditory cortex to changing background noise
How does the auditory system allow for accurate speech perception against changes in background noise? Here, using neural activity in the auditory cortex as people listen to speech, the authors provide evidence that background noise is selectively suppressed to enhance representations of speech.
- Bahar Khalighinejad
- , Jose L. Herrero
- & Nima Mesgarani
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Article
| Open AccessSpeaker-normalized sound representations in the human auditory cortex
Our perception of a speech sound tends to remain stable despite variation in people’s vocal characteristics. Here, by measuring neural activity as people listened to speech from different voices, the authors provide evidence for speaker normalization processes in the human auditory cortex.
- Matthias J. Sjerps
- , Neal P. Fox
- & Edward F. Chang
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Article
| Open AccessMemory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory
Little is known about mechanisms that regulate the involvement of cortical engram cells in remote memory. Here, authors demonstrate that memory consolidation by mPFC engram cells requires CREB-mediated transcription, with the functionality of this network hub being gated by memory strength.
- Mariana R. Matos
- , Esther Visser
- & Michel C. van den Oever
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Article
| Open AccessCortical recruitment determines learning dynamics and strategy
Sounds vary in the strength of behavioural conditioning they can evoke, a property attributed to stimulus salience. Here, the authors show that stimulus salience the overall level of neuronal activity recruited in the auditory cortex is strongly related with its reinforcing strength.
- Sebastian Ceballo
- , Jacques Bourg
- & Brice Bathellier
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Article
| Open AccessOptimal features for auditory categorization
Vocalizations such as speech or animal calls have high variability in production. Here, the authors report that a few mid-level acoustic features provide sufficient information to generalize across this variability and classify vocalization types and auditory cortical neurons exhibit tuning to these features.
- Shi Tong Liu
- , Pilar Montes-Lourido
- & Srivatsun Sadagopan
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Article
| Open AccessPath integration maintains spatial periodicity of grid cell firing in a 1D circular track
In an open field, the preferential firing of grid cells on a hexagonal lattice is formed by integrating external as well as self-motion cues. Here, the authors show that on a 1D circular track, path integration cues shape the spatial selectivity of grid cells while external cues determine the scale of the grid.
- Pierre-Yves Jacob
- , Fabrizio Capitano
- & Francesca Sargolini
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Article
| Open AccessEye activity tracks task-relevant structures during speech and auditory sequence perception
Our eyes constantly follow objects we see, but do they also move in synchrony with auditory inputs? Here, the authors show that eyelid movements track the temporal structure of speech and other sound sequences, which could reflect a role of motor systems in temporal attention and sequence processing.
- Peiqing Jin
- , Jiajie Zou
- & Nai Ding
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Article
| Open AccessSound identity is represented robustly in auditory cortex during perceptual constancy
Perceptual constancy requires neural representations selective for object identity, yet tolerant of identity-preserving transformations. Here, the authors show that sound identity is represented robustly in auditory cortex and that behavioral generalization requires precise timing of identity information.
- Stephen M. Town
- , Katherine C. Wood
- & Jennifer K. Bizley
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Article
| Open AccessA retrieval-specific mechanism of adaptive forgetting in the mammalian brain
Forgetting is ubiquitous across the animal kingdom, but neuroscience is only beginning to address its mechanisms. This study shows that rats, like humans, actively forget memories that interfere with retrieval, and that this retrieval-induced forgetting requires the prefrontal cortex.
- Pedro Bekinschtein
- , Noelia V. Weisstaub
- & Michael C. Anderson
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Article
| Open AccessEncoding of long-term associations through neural unitization in the human medial temporal lobe
In this work, the authors recorded single neurons and field potentials from the human medial temporal lobe (MTL) and show indistinguishable responses to associated stimuli. This coding mechanism provides a simple and flexible way of encoding memories in the human MTL.
- Hernan G. Rey
- , Emanuela De Falco
- & Rodrigo Quian Quiroga
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Article
| Open AccessDopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
The success of extinction learning is not predictive of long-term retrieval of an extinction memory. Using fMRI to study consolidation of fear extinction in human subjects, the authors show that reactivation in the ventromedial prefrontal cortex during memory retrieval predicts extinction memory retrieval, and that increasing dopaminergic signaling increases the number of these activations.
- A. M. V. Gerlicher
- , O. Tüscher
- & R. Kalisch
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Article
| Open AccessPerceptual learning of fine contrast discrimination changes neuronal tuning and population coding in macaque V4
Perceptual learning, the improvement in perceptual abilities with training, is thought to involve changes in neuronal 'tuning'. Here, the authors show that perceptual learning works by making neurons increasingly sensitive to task-relevant differences in stimuli, and by improving population coding mechanisms.
- Mehdi Sanayei
- , Xing Chen
- & Alexander Thiele
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Article
| Open AccessRich spatio-temporal stimulus dynamics unveil sensory specialization in cortical area S2
Sensory tuning properties of neurons in the secondary whisker somatosensory cortex (wS2) are not well understood. Here, the authors report that wS2 neurons supralinearly integrate concurrent multi-whisker input with larger temporal windows than primary somatosensory cortex.
- Matías A. Goldin
- , Evan R. Harrell
- & Daniel E. Shulz
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Article
| Open AccessKetamine reduces aversion in rodent pain models by suppressing hyperactivity of the anterior cingulate cortex
Ketamine is a short-acting analgesic that also has anti-depressant effects. Here the authors show in rat models of chronic pain that low-dose ketamine can induce an anti-aversive state that persists after the initial short term analgesia has ended.
- Haocheng Zhou
- , Qiaosheng Zhang
- & Jing Wang
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Article
| Open AccessSaccade metrics reflect decision-making dynamics during urgent choices
Saccades have been extensively used to report choices in perceptual decision making studies yet little is known about the influence of covert decision-related processes on saccade metrics. Here, the authors demonstrate that saccade kinematics is a reliable tell about the degree of decision certainty.
- Joshua A. Seideman
- , Terrence R. Stanford
- & Emilio Salinas
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Article
| Open AccessAuditory cortical activity drives feedback-dependent vocal control in marmosets
During vocalization, mammals change their vocal production to compensate for altered auditory feedback. Here, Eliades and Tsunada show that neural activity in the marmoset’s auditory cortex mediates this effect, and that stimulation of the auditory cortex evokes similar changes in vocalization.
- Steven J. Eliades
- & Joji Tsunada
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Article
| Open AccessGo/No-Go task engagement enhances population representation of target stimuli in primary auditory cortex
Sensory areas are thought to process stimulus information while higher-order processing occurs in association cortices. Here the authors report that during task engagement population activity in ferret primary auditory cortex shifts away from encoding stimulus features toward detection of the behaviourally relevant targets.
- Sophie Bagur
- , Martin Averseng
- & Srdjan Ostojic
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Article
| Open AccessSensory overamplification in layer 5 auditory corticofugal projection neurons following cochlear nerve synaptic damage
Deep layer auditory cortex neurons project to a number of limbic and subcortical auditory structures. Here, the authors show how these corticofugal projections adjust response gain following noise-induced cochlear damage.
- Meenakshi M. Asokan
- , Ross S. Williamson
- & Daniel B. Polley
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Article
| Open AccessNeural mechanisms for selectively tuning in to the target speaker in a naturalistic noisy situation
When many people are speaking, e.g. at a party, we can selectively attend to just one speaker. Here, using ‘hyperscanning’, the authors show that interpersonal neural synchronization is selectively increased between a listener and the attended speaker, compared to between the listener and an unattended speaker.
- Bohan Dai
- , Chuansheng Chen
- & Chunming Lu
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Article
| Open AccessSpecific hippocampal representations are linked to generalized cortical representations in memory
Memory representations in cortex and hippocampus are reactivated during sharp-wave ripple (SWR) events. Here, the authors show that, in a familiar environment, this activity preferentially links spatially selective hippocampal cells and task general PFC representations, pointing to a potential neural mechanism for generalization of individual experiences.
- Jai Y. Yu
- , Daniel F. Liu
- & Loren M. Frank
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Article
| Open AccessON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity
Auditory cortex neurons exhibit distinct frequency tuning to sound onset and offset. Here the authors demonstrate that during development ON-OFF receptive fields diverge to occupy adjacent frequency ranges that may underlie their direction selective responses to frequency modulated sweeps.
- Joseph Sollini
- , Gaëlle A. Chapuis
- & Paul Chadderton
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Article
| Open AccessAsynchronous suppression of visual cortex during absence seizures in stargazer mice
Absence epilepsy is associated with frequent generalized spike-wave seizures and loss of awareness. Here the authors use 2-photon calcium imaging of primary visual cortex in a genetic mouse model of absence epilepsy and find that cortical neurons are less active and more loosely coupled to the seizure EEG signature than previously believed.
- Jochen Meyer
- , Atul Maheshwari
- & Stelios Smirnakis
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Article
| Open AccessNeural encoding and production of functional morphemes in the posterior temporal lobe
Functional morphemes allow us to express details about objects, events, and their relationships. Here, authors show that inhibiting a small cortical area within left posterior superior temporal lobe selectively impairs the ability to produce functional morphemes but does not impair other linguistic abilities.
- Daniel K. Lee
- , Evelina Fedorenko
- & Ziv M. Williams
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Article
| Open AccessLayer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers
Several studies have suggested that astrocytes in the neocortex are more diverse than previously thought. Here, the authors describe layer-specific differences in morphology and molecular characteristics of astrocytes that depend on the neurons within those layers.
- Darin Lanjakornsiripan
- , Baek-Jun Pior
- & Yukiko Gotoh
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Review Article
| Open AccessProgress and challenges for understanding the function of cortical microcircuits in auditory processing
Advances in multi-neuron recordings and optogenetic manipulation have resulted in an interrogation of the function of specific cortical cell types in auditory cortex during sound processing. Here, the authors review this literature and discuss the merits of integrating computational approaches from dynamic network science.
- Jennifer M. Blackwell
- & Maria N. Geffen
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Article
| Open AccessNeurons along the auditory pathway exhibit a hierarchical organization of prediction error
Perception can be explained by predictive coding, but it is unclear how this theory applies at the single-neuron level. Here, authors describe how auditory patterns are encoded and detected by single neurons along the auditory pathway, demonstrating that prediction error exists in single auditory neurons.
- Gloria G. Parras
- , Javier Nieto-Diego
- & Manuel S. Malmierca
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Article
| Open AccessPerturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior
Functional consequence of transient delay in neuronal migration is unclear. This study shows that Wnt/C-Kit signaling regulates radial migration in rat somatosensory cortex, and that transient delay of L2/3 neuronal migration leads to interhemispheric connectivity alteration and abnormal social behavior.
- Riccardo Bocchi
- , Kristof Egervari
- & Jozsef Z. Kiss
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Article
| Open AccessCortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents
Different stages of sleep, marked by particular electroencephalographic (EEG) signatures, have been linked to memory consolidation, but underlying mechanisms are poorly understood. Here, the authors show that dendritic calcium synchronisation correlates with spindle-rich sleep phases.
- Julie Seibt
- , Clément J. Richard
- & Matthew E. Larkum
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Article
| Open AccessSparse orthogonal population representation of spatial context in the retrosplenial cortex
Neurons in the retrosplenial cortex (RSC) encode spatial and navigational signals. Here the authors use calcium imaging to show that, similar to the hippocampus, RSC neurons also encode place cell-like activity in a sparse orthogonal representation, partially anchored to the allocentric cues on the linear track.
- Dun Mao
- , Steffen Kandler
- & Vincent Bonin