Corneal diseases articles within Nature Communications

Featured

• Article
  17 June 2023 | Open Access

  Snowflake-inspired and blink-driven flexible piezoelectric contact lenses for effective corneal injury repair

  The cornea is susceptible to various injuries with a complicated repair process. Here, the authors propose a snowflake-inspired, blink-driven flexible piezoelectric contact lens for corneal injury repair.

  • Guang Yao
  • , Xiaoyi Mo
  •  & Yuan Lin

• Article
  30 November 2022 | Open Access

  Perfluorodecalin-based oxygenated emulsion as a topical treatment for chemical burn to the eye

  Chemical injuries to the eye are medical emergencies with limited acute treatment options and can cause permanent vision loss. Here, the authors show that perfluorodecalin-based supersaturated oxygen emulsion is a safe and effective topical therapeutic in treating acute ocular chemical burn by reducing tissue hypoxia and inflammation.

  • Sanming Li
  • , Kunpeng Pang
  •  & Jia Yin

• Article
  12 December 2019 | Open Access

  TRPV1 activity and substance P release are required for corneal cold nociception

  The eye shows protective responses to noxious stimuli including cold. Here, the authors show that TRPV1, found co-expressed on TRPM8 + fibres in the cornea, is necessary for cold nociception in the eye.

  • Fengxian Li
  • , Weishan Yang
  •  & Qin Liu

• Article
  03 April 2019 | Open Access

  Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

  The link between how the stiffness of the cornea affects stem cells is unclear. Here, the authors use Brillouin spectro-microscopy to show that mechanical properties of the cornea affect epithelial stem cells and after injury, treating the cornea with collagenase suppresses YAP activation, assisting in regeneration.

  • Ricardo M. Gouveia
  • , Guillaume Lepert
  •  & Che J. Connon

• Article
  20 March 2019 | Open Access

  Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density

  The corneal endothelium is crucial for proper vision. Here, Ivarsdottir et al. perform genome-wide association studies for various corneal endothelial cell measurements and find that an intergenic variant near ANAPC1 explains 24% of the variance of endothelial cell density and associates with corneal hysteresis.

  • Erna V. Ivarsdottir
  • , Stefania Benonisdottir
  •  & Kari Stefansson

• Article
  30 March 2017 | Open Access

  Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy

  Fuchs endothelial corneal dystrophy (FECD) is one of the most common reasons for corneal transplantation, and is known to cluster in families. Here, the authors discover new genetic loci associated with FECD with sex-specific effects and implications for disease mechanism.

  • Natalie A. Afshari
  • , Robert P. Igo Jr
  •  & Sudha K. Iyengar