Computational biophysics

Computational biophysics uses numerical algorithms to study the physical principles underlying biological phenomena and processes. It provides a means of approximating solutions for theoretical biophysical problems lacking closed-form solutions, and simulating systems for which experiments are deemed infeasible.

Latest Research and Reviews

News and Comment

  • News and Views |

    Whether a cell divides symmetrically or asymmetrically during early development determines the fate of its progeny. Now cell size has emerged as a key player in making this decision.

    • Alexandra Jilkine
    Nature Physics 15, 987
  • News and Views |

    Misfolded protein aggregates are a classical hallmark of many neurodegenerative diseases. By combining a mouse model of misfolded protein injection and a brain network model of misfolded protein diffusion, a study now finds a strong link between the stereotypical spreading patterns of neurodegeneration, protein expression and anatomical connectivity.

    • Ellen Kuhl
    Nature Neuroscience 22, 1200-1202
  • News and Views |

    A strategy using pressure was devised to structurally identify conformational transitions in protein ensembles, allowing the rational prediction of mutations that induce pressure-driven enzyme activation. These results highlight the power of flexibility–function analyses in protein engineering design and applications.

    • Nicolas Doucet
    Nature Catalysis 2, 646-647