Computational biology and bioinformatics

Definition

Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology. The computational methods used include analytical methods, mathematical modelling and simulation.

Featured

Latest Research and Reviews

  • Research | | open

    Cybergenetics aims to monitor and regulate cellular processes in real-time using computer monitoring and feedback of biological readouts. Here the authors use a feedback loop and periodic forcing to maintain cells with a bistable synthetic circuit near its unstable state.

    • Jean-Baptiste Lugagne
    • , Sebastián Sosa Carrillo
    • , Melanie Kirch
    • , Agnes Köhler
    • , Gregory Batt
    •  & Pascal Hersen
  • Research | | open

    The effect of knots on protein stability and folding kinetics is not well understood. Here the authors combine optical tweezer experiments and calculations to experimentally determine the energy cost for knot formation, which indicates that knotted proteins evolved specific folding pathways because knot formation in unfolded chains is unfavorable.

    • Andrés Bustamante
    • , Juan Sotelo-Campos
    • , Daniel G. Guerra
    • , Martin Floor
    • , Christian M. A. Wilson
    • , Carlos Bustamante
    •  & Mauricio Báez
  • Research | | open

    The role of lncRNA is unclear with respect to epithelial-to-mesenchymal transition (EMT), which is linked to ovarian cancer metastasis. Here, the authors show lncRNA DNM3OS expression contributes to ovarian cancer EMT, cell migration/invasion, and correlates with worse overall patient survival.

    • Ramkrishna Mitra
    • , Xi Chen
    • , Evan J. Greenawalt
    • , Ujjwal Maulik
    • , Wei Jiang
    • , Zhongming Zhao
    •  & Christine M. Eischen
  • Research | | open

    Individual bacteria interact with each other and their environment to produce population-level patterns of gene expression. Here the authors use an automated platform combined with optogenetic feedback to manipulate population behaviors through dynamic control of individual cells.

    • Remy Chait
    • , Jakob Ruess
    • , Tobias Bergmiller
    • , Gašper Tkačik
    •  & Călin C. Guet
  • Research | | open

    Esophageal squamous cell carcinoma (ESCC) exhibits differences in incidence and survival patterns among races. Here, analysis of Chinese and TCGA ESCC patients reveals that Asian patients exhibit higher TP53, EP300 and NFE2L2 mutational frequencies, and mutated CSMD3 associates with better prognosis.

    • Jiaying Deng
    • , Hu Chen
    • , Daizhan Zhou
    • , Junhua Zhang
    • , Yun Chen
    • , Qi Liu
    • , Dashan Ai
    • , Hanting Zhu
    • , Li Chu
    • , Wenjia Ren
    • , Xiaofei Zhang
    • , Yi Xia
    • , Menghong Sun
    • , Huiwen Zhang
    • , Jun Li
    • , Xinxin Peng
    • , Liang Li
    • , Leng Han
    • , Hui Lin
    • , Xiujun Cai
    • , Jiaqing Xiang
    • , Shufeng Chen
    • , Yihua Sun
    • , Yawei Zhang
    • , Jie Zhang
    • , Haiquan Chen
    • , Shijian Zhang
    • , Yi Zhao
    • , Yun Liu
    • , Han Liang
    •  & Kuaile Zhao

News and Comment