Computational biology and bioinformatics

Computational biology and bioinformatics is an interdisciplinary field that develops and applies computational methods to analyse large collections of biological data, such as genetic sequences, cell populations or protein samples, to make new predictions or discover new biology. The computational methods used include analytical methods, mathematical modelling and simulation.

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Latest Research and Reviews

  • Research | | open

    Integration of omics data remains a challenge. Here, the authors introduce iCell, a framework to integrate tissue-specific protein–protein interaction, co-expression and genetic interaction data, enabling identification of the most rewired genes in cancer, unidentifiable in individual data layers.

    • Noël Malod-Dognin
    • , Julia Petschnigg
    • , Sam F. L. Windels
    • , Janez Povh
    • , Harry Hemmingway
    • , Robin Ketteler
    •  & Nataša Pržulj
  • Research | | open

    Analogue regulation of gene expression is important for normal function in mammals but existing genetic technologies are designed to achieve ON/OFF control. Here the authors develop synthetic microRNA silencing-mediated fine-tuners (miSFITs) to precisely control target gene expression levels.

    • Yale S. Michaels
    • , Mike B. Barnkob
    • , Hector Barbosa
    • , Toni A. Baeumler
    • , Mary K. Thompson
    • , Violaine Andre
    • , Huw Colin-York
    • , Marco Fritzsche
    • , Uzi Gileadi
    • , Hilary M. Sheppard
    • , David J. H. F. Knapp
    • , Thomas A. Milne
    • , Vincenzo Cerundolo
    •  & Tudor A. Fulga
  • Research | | open

    The resolution limitations when using the ubiquitous algorithms that process images obtained using modern techniques are not straightforward to define. Here, the authors examine the performance of localization algorithms and use spatial statistics to provide a metric for assessing the resolution limit of such algorithms.

    • Edward A. K. Cohen
    • , Anish V. Abraham
    • , Sreevidhya Ramakrishnan
    •  & Raimund J. Ober
  • Research | | open

    Shape transformation of proteins created by design in the laboratory is challenging. Here, the authors present a disulfide-mediated approach for the preparation of 16-mer, 24-mer, and 48-mer nanocages from an 8-mer bowl-like protein building block.

    • Jiachen Zang
    • , Hai Chen
    • , Xiaorong Zhang
    • , Chenxi Zhang
    • , Jing Guo
    • , Ming Du
    •  & Guanghua Zhao
  • Research |

    • Maxim Signaevsky
    • , Marcel Prastawa
    • , Kurt Farrell
    • , Nabil Tabish
    • , Elena Baldwin
    • , Natalia Han
    • , Megan A. Iida
    • , John Koll
    • , Clare Bryce
    • , Dushyant Purohit
    • , Vahram Haroutunian
    • , Ann C. McKee
    • , Thor D. Stein
    • , Charles L. White III
    • , Jamie Walker
    • , Timothy E. Richardson
    • , Russell Hanson
    • , Michael J. Donovan
    • , Carlos Cordon-Cardo
    • , Jack Zeineh
    • , Gerardo Fernandez
    •  & John F. Crary

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