Computational biology and bioinformatics

  • Article | | open

    The resolution limitations when using the ubiquitous algorithms that process images obtained using modern techniques are not straightforward to define. Here, the authors examine the performance of localization algorithms and use spatial statistics to provide a metric for assessing the resolution limit of such algorithms.

    • Edward A. K. Cohen
    • , Anish V. Abraham
    • , Sreevidhya Ramakrishnan
    •  & Raimund J. Ober
  • Article | | open

    SecB homologs can be associated with stress-responsive type II toxin–antitoxin (TA) systems and form tripartite toxin-antitoxin-chaperone systems (TAC). Here the authors provide structural insights into TACs by presenting the crystal structure of the M. tuberculosis TA-associated SecB chaperone in complex with the C-terminal ChAD (chaperone addiction) extension of the antitoxin HigA1.

    • Valérie Guillet
    • , Patricia Bordes
    • , Cécile Bon
    • , Julien Marcoux
    • , Virginie Gervais
    • , Ambre Julie Sala
    • , Suzana Dos Reis
    • , Nawel Slama
    • , Israel Mares-Mejía
    • , Anne-Marie Cirinesi
    • , Laurent Maveyraud
    • , Pierre Genevaux
    •  & Lionel Mourey
  • Article | | open

    The reinforcement learning literature suggests decisions are based on a model-free system, operating retrospectively, and a model-based system, operating prospectively. Here, the authors show that a model-based retrospective inference of a reward’s cause, guides model-free credit-assignment.

    • Rani Moran
    • , Mehdi Keramati
    • , Peter Dayan
    •  & Raymond J. Dolan
  • Article | | open

    The diurnal cycle exerts influences on various aspects of plant biology. Here, the authors generate and compare diurnal transcriptomics data from nine members of Archaeplastida representing major clades.

    • Camilla Ferrari
    • , Sebastian Proost
    • , Marcin Janowski
    • , Jörg Becker
    • , Zoran Nikoloski
    • , Debashish Bhattacharya
    • , Dana Price
    • , Takayuki Tohge
    • , Arren Bar-Even
    • , Alisdair Fernie
    • , Mark Stitt
    •  & Marek Mutwil
  • Article | | open

    The antitermination factor RfaH adopts two functional states where its C-terminal domain is folded either as an α-helical hairpin or β-barrel. Here the authors employ solution state NMR measurements to show that the C-terminal domain transforms into the β-barrel only upon binding to the elongation complex and refolds back after dissociation.

    • Philipp Konrad Zuber
    • , Kristian Schweimer
    • , Paul Rösch
    • , Irina Artsimovitch
    •  & Stefan H. Knauer
  • Article | | open

    Innate T cells (ITC) contain many subsets and are poised to promptly respond to antigens and pathogens, but how this poised state is maintained is still unclear. Here the authors perform single-cell RNA-seq to align the various ITC subsets along an ‘innateness gradient’ that is associated with changes in proliferation and effector functions.

    • Maria Gutierrez-Arcelus
    • , Nikola Teslovich
    • , Alex R. Mola
    • , Rafael B. Polidoro
    • , Aparna Nathan
    • , Hyun Kim
    • , Susan Hannes
    • , Kamil Slowikowski
    • , Gerald F. M. Watts
    • , Ilya Korsunsky
    • , Michael B. Brenner
    • , Soumya Raychaudhuri
    •  & Patrick J. Brennan
  • Article | | open

    Many 2-Cystein Peroxiredoxins (Prx) can either function as peroxidases or chaperones when exposed to stress. Here the authors present the structures of Leishmania infantum mitochondrial Prx alone and with a bound model client protein, use crosslinking to reveal interaction regions that stabilize the bound client, and provide insights into the mechanism by which Prx’s adopt chaperone activity.

    • Filipa Teixeira
    • , Eric Tse
    • , Helena Castro
    • , Karl A. T. Makepeace
    • , Ben A. Meinen
    • , Christoph H. Borchers
    • , Leslie B. Poole
    • , James C. Bardwell
    • , Ana M. Tomás
    • , Daniel R. Southworth
    •  & Ursula Jakob
  • Article | | open

    A fundamental step in membrane protein biogenesis is their integration into the lipid bilayer with a defined orientation of each transmembrane segment. Here, the authors show that mutations in connexin 32 can cause failures in membrane integration which is detected by the ER chaperone machinery.

    • João P. L. Coelho
    • , Matthias Stahl
    • , Nicolas Bloemeke
    • , Kevin Meighen-Berger
    • , Carlos Piedrafita Alvira
    • , Zai-Rong Zhang
    • , Stephan A. Sieber
    •  & Matthias J. Feige
  • Article | | open

    Zinc ions (Zn2+) are imported by Golgi-resident transporters but the function of zinc in the early secretory pathway has remained unknown. Here the authors find that Zn2+ regulates protein quality control in the early secretory pathway by demonstrating that the pH-sensitive chaperone ERp44 binds Zn2+ and solving the Zn2+-bound ERp44 structure.

    • Satoshi Watanabe
    • , Yuta Amagai
    • , Sara Sannino
    • , Tiziana Tempio
    • , Tiziana Anelli
    • , Manami Harayama
    • , Shoji Masui
    • , Ilaria Sorrentino
    • , Momo Yamada
    • , Roberto Sitia
    •  & Kenji Inaba
  • Article | | open

    N6-methyladenine is involved in many biological pathways for microbial survival and host interaction. Here the authors train a neural network for improved m6A detection in nanopore sequencing data and validate methylomes for a microbial reference community.

    • Alexa B. R. McIntyre
    • , Noah Alexander
    • , Kirill Grigorev
    • , Daniela Bezdan
    • , Heike Sichtig
    • , Charles Y. Chiu
    •  & Christopher E. Mason
  • Article | | open

    Information of genetic architectures of complex traits can be leveraged for predicting phenotypes. Here, the authors develop CTPR (Cross-Trait Penalized Regression), a method for multi-trait polygenic risk prediction using individual-level genotypes and/or summary statistics from large cohorts.

    • Wonil Chung
    • , Jun Chen
    • , Constance Turman
    • , Sara Lindstrom
    • , Zhaozhong Zhu
    • , Po-Ru Loh
    • , Peter Kraft
    •  & Liming Liang
  • Article | | open

    An unresolved problem in neuroscience is to determine the relevant timescale for understanding spatiotemporal dynamics of the brain. Here, the authors introduce a new framework to study the different timescales through binning the output of a generative model of neural activity.

    • Gustavo Deco
    • , Josephine Cruzat
    •  & Morten L. Kringelbach
  • Article | | open

    The role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in maintenance of protein folding homeostasis inside the ER has remained unclear. Here the authors determine the structure of the complex between MANF and the ER-localized chaperone BiP and provide evidence that MANF serves as an anti-nucleotide exchange factor for BiP.

    • Yahui Yan
    • , Claudia Rato
    • , Lukas Rohland
    • , Steffen Preissler
    •  & David Ron
  • Article | | open

    Seasonal malaria chemoprevention provides substantial benefit for young children, but resistance to used drugs will likely develop. Here, Chotsiri et al. evaluate the use of dihydroartemisinin-piperaquine as a regimen in 179 children, and population-based simulations suggest that small children would benefit from a higher and extended dosage.

    • Palang Chotsiri
    • , Issaka Zongo
    • , Paul Milligan
    • , Yves Daniel Compaore
    • , Anyirékun Fabrice Somé
    • , Daniel Chandramohan
    • , Warunee Hanpithakpong
    • , François Nosten
    • , Brian Greenwood
    • , Philip J. Rosenthal
    • , Nicholas J. White
    • , Jean-Bosco Ouédraogo
    •  & Joel Tarning
  • Article | | open

    The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear. Here authors show that nucleoplasmic LDs in hepatocytes are derived from apolipoprotein B (ApoB)-free lumenal LDs and constitute a feedback mechanism to regulate PC synthesis in accordance with ER stress.

    • Kamil Sołtysik
    • , Yuki Ohsaki
    • , Tsuyako Tatematsu
    • , Jinglei Cheng
    •  & Toyoshi Fujimoto
  • Article | | open

    Designing interfaces that can induce protein-protein interactions is a challenging problem. Here the authors show that a five amino acid sequence known to mediate domain swapping in cystatins can drive oligomerization when grafted onto functionally and structurally unrelated host proteins, providing a simple approach to the design of protein assemblies.

    • Neha Nandwani
    • , Parag Surana
    • , Hitendra Negi
    • , Nahren M. Mascarenhas
    • , Jayant B. Udgaonkar
    • , Ranabir Das
    •  & Shachi Gosavi
  • Article | | open

    Transcription factors of the AP-1 family can play diverse roles despite recognizing the same DNA sequence. Here the authors investigate the DNA binding activities of AP-1 members in mouse macrophages and apply a machine learning approach to identify motifs predicted to drive factor-specific binding profiles.

    • Gregory J. Fonseca
    • , Jenhan Tao
    • , Emma M. Westin
    • , Sascha H. Duttke
    • , Nathanael J. Spann
    • , Tobias Strid
    • , Zeyang Shen
    • , Joshua D. Stender
    • , Mashito Sakai
    • , Verena M. Link
    • , Christopher Benner
    •  & Christopher K. Glass
  • Article | | open

    Real-time deformability cytometry (RT-DC) is used for mechanical cell phenotyping but is limited to a single snapshot per cell and can only measure elastic modulus. Here the authors introduce dynamic RT-DC which can measure elasticity and viscosity in single cells by following dynamic cell shape changes.

    • Bob Fregin
    • , Fabian Czerwinski
    • , Doreen Biedenweg
    • , Salvatore Girardo
    • , Stefan Gross
    • , Konstanze Aurich
    •  & Oliver Otto
  • Article | | open

    Single-cell RNA sequencing is a powerful method to study gene expression, but noise in the data can obstruct analysis. Here the authors develop a denoising method based on a deep count autoencoder network that scales linearly with the number of cells, and therefore is compatible with large data sets.

    • Gökcen Eraslan
    • , Lukas M. Simon
    • , Maria Mircea
    • , Nikola S. Mueller
    •  & Fabian J. Theis
  • Article | | open

    Focal amplifications are prevalent in many cancer genomes. Here, the authors present AmpliconArchitect (AA), a computational tool for reconstructing their architecture, and reveal an extrachromosomal origin for focal amplifications, including hybrid human-virus elements in HPV-mediated cancers.

    • Viraj Deshpande
    • , Jens Luebeck
    • , Nam-Phuong D. Nguyen
    • , Mehrdad Bakhtiari
    • , Kristen M. Turner
    • , Richard Schwab
    • , Hannah Carter
    • , Paul S. Mischel
    •  & Vineet Bafna
  • Article | | open

    The Cas12b family of CRISPR nucleases has been underutilized in mammalian cells due to the high temperature requirement of known members. Here the authors engineer BhCas12b to overcome this limitation for robust and specific genome editing applications in human cells.

    • Jonathan Strecker
    • , Sara Jones
    • , Balwina Koopal
    • , Jonathan Schmid-Burgk
    • , Bernd Zetsche
    • , Linyi Gao
    • , Kira S. Makarova
    • , Eugene V. Koonin
    •  & Feng Zhang
  • Article | | open

    Bulk tissue RNA-seq data reveals transcriptomic profiles but masks the contributions of different cell types. Here, the authors develop a new method for estimating cell type proportions from bulk tissue RNA-seq data guided by multi-subject single-cell expression reference.

    • Xuran Wang
    • , Jihwan Park
    • , Katalin Susztak
    • , Nancy R. Zhang
    •  & Mingyao Li
  • Article | | open

    Single-cell transcriptomic profiling allows the exploration of cellular heterogeneity but commonly focuses on the 3′-end of the transcript. Here the authors introduce C1 CAGE, which detects the 5′ transcript end in a multiplexed microfluidic system.

    • Tsukasa Kouno
    • , Jonathan Moody
    • , Andrew Tae-Jun Kwon
    • , Youtaro Shibayama
    • , Sachi Kato
    • , Yi Huang
    • , Michael Böttcher
    • , Efthymios Motakis
    • , Mickaël Mendez
    • , Jessica Severin
    • , Joachim Luginbühl
    • , Imad Abugessaisa
    • , Akira Hasegawa
    • , Satoshi Takizawa
    • , Takahiro Arakawa
    • , Masaaki Furuno
    • , Naveen Ramalingam
    • , Jay West
    • , Harukazu Suzuki
    • , Takeya Kasukawa
    • , Timo Lassmann
    • , Chung-Chau Hon
    • , Erik Arner
    • , Piero Carninci
    • , Charles Plessy
    •  & Jay W. Shin
  • Article | | open

    Prion-forming proteins have been found in animals, plants, fungi, and bacteria. Here, Nan et al. report that a baculovirus-encoded protein behaves as prion in a yeast system and forms aggregates at high multiplicity of infection in insect cells that affect baculovirus replication.

    • Hao Nan
    • , Hongying Chen
    • , Mick F. Tuite
    •  & Xiaodong Xu
  • Article | | open

    Researchers can make use of a variety of computational tools to prioritize genetic variants and predict their pathogenicity. Here, the authors evaluate the performance of six of these tools in three typical biological tasks and find generally low concordance of predictions and experimental confirmation.

    • Li Liu
    • , Maxwell D. Sanderford
    • , Ravi Patel
    • , Pramod Chandrashekar
    • , Greg Gibson
    •  & Sudhir Kumar
  • Article | | open

    How the brain tracks the passage of time remains unclear. Here, the authors show that tracking activation changes in a neural network trained to recognize objects (similar to the human visual system) produces estimates of duration that are subject to human-like biases.

    • Warrick Roseboom
    • , Zafeirios Fountas
    • , Kyriacos Nikiforou
    • , David Bhowmik
    • , Murray Shanahan
    •  & Anil K. Seth
  • Article | | open

    Near-infrared (NIR) fluorescent proteins (FPs) offer advantages for spectral multiplexing and deep-tissue imaging. Here the authors engineer a smaller NIR FP based on the unexplored cyanobacteriochrome photoreceptor and demonstrate its use in various applications in cell culture as well as whole-body imaging in vivo in mice.

    • Olena S. Oliinyk
    • , Anton A. Shemetov
    • , Sergei Pletnev
    • , Daria M. Shcherbakova
    •  & Vladislav V. Verkhusha
  • Article | | open

    Allostery is a fundamental principle of protein regulation that remains challenging to engineer. Here authors screen human Inward Rectifier K + Channel Kir2.1 for permissibility to domain insertions and propose that differential permissibility is a metric of latent allosteric capacity in Kir2.1.

    • Willow Coyote-Maestas
    • , Yungui He
    • , Chad L. Myers
    •  & Daniel Schmidt
  • Article | | open

    Many organs develop through branching morphogenesis, but whether the underlying mechanisms are shared is unknown. Here, the authors show that a ligand-receptor based Turing mechanisms, similar to that observed in lung development, likely underlies branching morphogenesis of the kidney.

    • Denis Menshykau
    • , Odyssé Michos
    • , Christine Lang
    • , Lisa Conrad
    • , Andrew P. McMahon
    •  & Dagmar Iber
  • Article | | open

    Deubiquitinating enzymes (DUBs) are critical regulators of cellular processes by removing ubiquitin from specific targets. Here global kinetic modelling reveals the mechanism by which the low intrinsic activity of USP7 is substantially enhanced on a specific physiological target.

    • Robbert Q. Kim
    • , Paul P. Geurink
    • , Monique P. C. Mulder
    • , Alexander Fish
    • , Reggy Ekkebus
    • , Farid El Oualid
    • , Willem J. van Dijk
    • , Duco van Dalen
    • , Huib Ovaa
    • , Hugo van Ingen
    •  & Titia K. Sixma
  • Article | | open

    To explain the neural correlates of behavior and its variability, one must analyze single-trial population dynamics. Here, the authors develop a statistical method that extracts low-dimensional dynamics that explain behavior better than high-dimensional neural activity revealing unexpected structure.

    • Ziqiang Wei
    • , Hidehiko Inagaki
    • , Nuo Li
    • , Karel Svoboda
    •  & Shaul Druckmann
  • Article | | open

    Little is known about how the reconstruction of a memory unfolds in time in the human brain. Here, the authors provide evidence that the process of reconstructing the memory of an object involves a reversal of the information flow involved in the actual perception of that object.

    • Juan Linde-Domingo
    • , Matthias S. Treder
    • , Casper Kerrén
    •  & Maria Wimber
  • Article | | open

    Memories formed around the same time are linked together by a shared temporal context. Here, the authors show that the ability to selectively retrieve distinct episodic memories formed close together in time is related to how quickly neural representations of temporal context change over time during encoding.

    • Mostafa M. El-Kalliny
    • , John H. Wittig Jr
    • , Timothy C. Sheehan
    • , Vishnu Sreekumar
    • , Sara K. Inati
    •  & Kareem A. Zaghloul
  • Article | | open

    Protein structure determination in complex biological samples is still challenging. Here, the authors develop a computational modeling-guided cross-linking mass spectrometry method, obtaining a high-resolution model of a 1.8 MDa protein assembly from cross-links detected in a mixture of human plasma and bacteria.

    • Simon Hauri
    • , Hamed Khakzad
    • , Lotta Happonen
    • , Johan Teleman
    • , Johan Malmström
    •  & Lars Malmström
  • Article | | open

    Imbalanced proteostasis is associated with diverse diseases, including ischemia/reperfusion injury in the heart. Here the authors show that the ATF6 arm of the unfolded protein response can be pharmacologically activated with a small molecule in vivo, providing protection from ischemia/reperfusion injury in the heart, the brain, and the kidney.

    • Erik A. Blackwood
    • , Khalid Azizi
    • , Donna J. Thuerauf
    • , Ryan J. Paxman
    • , Lars Plate
    • , Jeffery W. Kelly
    • , R. Luke Wiseman
    •  & Christopher C. Glembotski
  • Article | | open

    Salmonella Typhimurium replicates within host phagocytes. Here, the authors show that a known psychoactive drug (metergoline) inhibits growth of the pathogen in macrophages, disrupts the proton motive force at the bacterial cytoplasmic membrane, and extends animal survival during systemic infection.

    • Michael J. Ellis
    • , Caressa N. Tsai
    • , Jarrod W. Johnson
    • , Shawn French
    • , Wael Elhenawy
    • , Steffen Porwollik
    • , Helene Andrews-Polymenis
    • , Michael McClelland
    • , Jakob Magolan
    • , Brian K. Coombes
    •  & Eric D. Brown
  • Article | | open

    Real-time disease surveillance can aid mitigation of outbreaks. Here, Lu et al. combine an approach using Google search and EHR data with an approach leveraging spatiotemporal synchronicities of influenza activity across states to improve state-level influenza activity estimates in the US.

    • Fred S. Lu
    • , Mohammad W. Hattab
    • , Cesar Leonardo Clemente
    • , Matthew Biggerstaff
    •  & Mauricio Santillana
  • Article | | open

    Analyzing the organization of molecular complexes in multi-color single-molecule localization microscopy data requires heavy computation resources that are impractical for laboratory computers. Here the authors develop a coordinate-based Triple-Correlation algorithm with improved speed and reduced computational cost.

    • Yandong Yin
    • , Wei Ting Chelsea Lee
    •  & Eli Rothenberg
  • Article | | open

    Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dynamics which perturb the selectivity filter.

    • Shehrazade Jekhmane
    • , João Medeiros-Silva
    • , Jing Li
    • , Felix Kümmerer
    • , Christoph Müller-Hermes
    • , Marc Baldus
    • , Benoît Roux
    •  & Markus Weingarth
  • Article | | open

    In considering cross-feeding among microbes within communities, it is typically assumed that metabolic secretions are costly to produce. However, Pacheco et al. use metabolic models to show that ‘costless’ secretions could be common in some environments and important for structuring interactions among microbes.

    • Alan R. Pacheco
    • , Mauricio Moel
    •  & Daniel Segrè
  • Article | | open

    Small molecule metabolites like phenylalanine can form amyloid-like structures but so far this has only been demonstrated in vitro. Here the authors generate a yeast in vivo model of adenine self-assembly and characterize the adenine assemblies in cells by indicative amyloid dye and anti-adenine assemblies antibodies.

    • Dana Laor
    • , Dorin Sade
    • , Shira Shaham-Niv
    • , Dor Zaguri
    • , Myra Gartner
    • , Vasantha Basavalingappa
    • , Avi Raveh
    • , Edward Pichinuk
    • , Hamutal Engel
    • , Keita Iwasaki
    • , Tatsuyuki Yamamoto
    • , Hemanth Noothalapati
    •  & Ehud Gazit
  • Article | | open

    The frontal cortex is involved in cognitive control, e.g. cognitive flexibility and behavioral inhibition, but the roles of frontal subdivisions are unclear. Here, the authors used computational modelling of cognitive control task performance to map lesions responsible for impairments in specific cognitive operations.

    • Jan Gläscher
    • , Ralph Adolphs
    •  & Daniel Tranel
  • Article | | open

    Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chemotypes with faster kill rates than existing anti-Wolbachia drugs.

    • Rachel H. Clare
    • , Catherine Bardelle
    • , Paul Harper
    • , W. David Hong
    • , Ulf Börjesson
    • , Kelly L. Johnston
    • , Matthew Collier
    • , Laura Myhill
    • , Andrew Cassidy
    • , Darren Plant
    • , Helen Plant
    • , Roger Clark
    • , Darren A. N. Cook
    • , Andrew Steven
    • , John Archer
    • , Paul McGillan
    • , Sitthivut Charoensutthivarakul
    • , Jaclyn Bibby
    • , Raman Sharma
    • , Gemma L. Nixon
    • , Barton E. Slatko
    • , Lindsey Cantin
    • , Bo Wu
    • , Joseph Turner
    • , Louise Ford
    • , Kirsty Rich
    • , Mark Wigglesworth
    • , Neil G. Berry
    • , Paul M. O’Neill
    • , Mark J. Taylor
    •  & Stephen A. Ward
  • Article | | open

    Due to various structural and sequence complexities, the human Y chromosome is challenging to sequence and characterize. Here, the authors develop a strategy to sequence native, unamplified flow sorted Y chromosomes with a nanopore sequencing platform, and report the first assembly of a human Y chromosome of African origin.

    • Lukas F. K. Kuderna
    • , Esther Lizano
    • , Eva Julià
    • , Jessica Gomez-Garrido
    • , Aitor Serres-Armero
    • , Martin Kuhlwilm
    • , Regina Antoni Alandes
    • , Marina Alvarez-Estape
    • , David Juan
    • , Heath Simon
    • , Tyler Alioto
    • , Marta Gut
    • , Ivo Gut
    • , Mikkel Heide Schierup
    • , Oscar Fornas
    •  & Tomas Marques-Bonet
  • Article | | open

    Genetic variants might exert their functional effects via influencing molecular interaction. Here, the authors present a resource featuring almost 28,000 annotations describing the effect of small sequence changes on physical protein interactions, curated by IMEx Consortium curators.

    • N. del-Toro
    • , M. Duesbury
    • , M. Koch
    • , L. Perfetto
    • , A. Shrivastava
    • , D. Ochoa
    • , O. Wagih
    • , J. Piñero
    • , M. Kotlyar
    • , C. Pastrello
    • , P. Beltrao
    • , L. I. Furlong
    • , I. Jurisica
    • , H. Hermjakob
    • , S. Orchard
    • , P. Porras
    • , J. Khadake
    • , B. Meldal
    • , S. Panni
    • , D. Thorneycroft
    • , K. van Roey
    • , S. Abbani
    • , L. Salwinski
    • , M. Pellegrini
    • , M. Iannuccelli
    • , L. Licata
    • , G. Cesareni
    • , B. Roechert
    • , A. Bridge
    • , M. G. Ammari
    • , F. McCarthy
    • , F. Broackes-Carter
    • , N. H. Campbell
    • , A. N. Melidoni
    • , M. Rodriguez-Lopez
    • , R. C. Lovering
    • , S. Jagannathan
    • , C. Chen
    • , D. J. Lynn
    • , S. Ricard-Blum
    • , U. Mahadevan
    •  & A. Raghunath
  • Article | | open

    Flaviviruses have emerged or re-emerged in several regions, but factors underlying emergence are incompletely understood. Here, Pandit et al. identify potential sylvatic reservoirs of flaviviruses and, in combination with vector distribution data, predict regions of global vulnerability.

    • Pranav S. Pandit
    • , Megan M. Doyle
    • , Katrina M. Smart
    • , Cristin C. W. Young
    • , Gaylen W. Drape
    •  & Christine K. Johnson
  • Article | | open

    Molecular circuits implementing fold-change detection (FCD) allow cells to respond to fold-change in signals regardless of absolute levels. Here, the authors find that meaning, attention and saturation similarly form an FCD circuit and produce the observed dynamics of human behavior in creative search.

    • Yuval Hart
    • , Hagar Goldberg
    • , Ella Striem-Amit
    • , Avraham E. Mayo
    • , Lior Noy
    •  & Uri Alon