Complement cascade articles within Nature

Featured

• Article | 08 September 2021

  A lymphocyte–microglia–astrocyte axis in chronic active multiple sclerosis

  Single-nucleus transcriptomics defines a diverse set of immune and glial cells at the chronically inflamed leading edge of demyelinated white matter lesions in patients with multiple sclerosis.

  • Martina Absinta
  • , Dragan Maric
  •  & Daniel S. Reich

• Article | 29 July 2020

  Association of COVID-19 inflammation with activation of the C5a–C5aR1 axis

  Blockade of the C5a–C5aR1 axis using anti-C5aR1 monoclonal antibodies prevented inflammation associated with COVID-19.

  • Julien Carvelli
  • , Olivier Demaria
  •  & Eric Vivier

• Article | 11 May 2020

  Complement genes contribute sex-biased vulnerability in diverse disorders

  Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

  • Nolan Kamitaki
  • , Aswin Sekar
  •  & Steven A. McCarroll

• Letter | 22 February 2017

  Complement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease

  Complement-activating glycosylceramide-specific autoantibodies drive a self-propagating cycle of glycosylceramide accumulation and inflammation in Gaucher disease.

  • Manoj K. Pandey
  • , Thomas A. Burrow
  •  & Gregory A. Grabowski