Here, by mining 18,521 complete bacterial genomes, the authors construct VFDB 2.0, an expanded database of virulence factor genes, consisting of 62,332 nonredundant orthologues and alleles with annotated host taxa using species-specific average nucleotide identity, and present MetaVF, a toolkit that facilitates precise identification and quantification of virulence factor genes carried by specific pathobionts in human gut metagenomes.
- Wanting Dong
- Xinyue Fan
- Baoli Zhu