Colorectal cancer

Colorectal cancer, also known as bowel cancer, is a cancer formed by uncontrolled cell growth in the colon or rectum (parts of the large intestine), or in the appendix. Genetic analysis shows that colon and rectal tumours are genetically the same cancer.

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Latest Research and Reviews

  • Research | | open

    In tumours aberrant epigenetic modifications can alter the transcriptional state. Here, the authors identify a common tumour-specific shift to transcriptional repression associated with DNA methylation and chromatin dysregulation at the transcription start site.

    • Mizuo Ando
    • , Yuki Saito
    • , Guorong Xu
    • , Nam Q. Bui
    • , Kate Medetgul-Ernar
    • , Minya Pu
    • , Kathleen Fisch
    • , Shuling Ren
    • , Akihiro Sakai
    • , Takahito Fukusumi
    • , Chao Liu
    • , Sunny Haft
    • , John Pang
    • , Adam Mark
    • , Daria A. Gaykalova
    • , Theresa Guo
    • , Alexander V. Favorov
    • , Srinivasan Yegnasubramanian
    • , Elana J. Fertig
    • , Patrick Ha
    • , Pablo Tamayo
    • , Tatsuya Yamasoba
    • , Trey Ideker
    • , Karen Messer
    •  & Joseph A. Califano
  • Research | | open

    In colorectal cancer (CRC), finding loci associated with risk may give insight into disease aetiology. Here, the authors report a genome-wide association analysis in Europeans of 34,627 CRC cases and 71,379 controls, and find 31 new risk loci and 17 new risk SNPs at previously reported loci.

    • Philip J. Law
    • , Maria Timofeeva
    • , Ceres Fernandez-Rozadilla
    • , Peter Broderick
    • , James Studd
    • , Juan Fernandez-Tajes
    • , Susan Farrington
    • , Victoria Svinti
    • , Claire Palles
    • , Giulia Orlando
    • , Amit Sud
    • , Amy Holroyd
    • , Steven Penegar
    • , Evropi Theodoratou
    • , Peter Vaughan-Shaw
    • , Harry Campbell
    • , Lina Zgaga
    • , Caroline Hayward
    • , Archie Campbell
    • , Sarah Harris
    • , Ian J. Deary
    • , John Starr
    • , Laura Gatcombe
    • , Maria Pinna
    • , Sarah Briggs
    • , Lynn Martin
    • , Emma Jaeger
    • , Archana Sharma-Oates
    • , James East
    • , Simon Leedham
    • , Roland Arnold
    • , Elaine Johnstone
    • , Haitao Wang
    • , David Kerr
    • , Rachel Kerr
    • , Tim Maughan
    • , Richard Kaplan
    • , Nada Al-Tassan
    • , Kimmo Palin
    • , Ulrika A. Hänninen
    • , Tatiana Cajuso
    • , Tomas Tanskanen
    • , Johanna Kondelin
    • , Eevi Kaasinen
    • , Antti-Pekka Sarin
    • , Johan G. Eriksson
    • , Harri Rissanen
    • , Paul Knekt
    • , Eero Pukkala
    • , Pekka Jousilahti
    • , Veikko Salomaa
    • , Samuli Ripatti
    • , Aarno Palotie
    • , Laura Renkonen-Sinisalo
    • , Anna Lepistö
    • , Jan Böhm
    • , Jukka-Pekka Mecklin
    • , Daniel D. Buchanan
    • , Aung-Ko Win
    • , John Hopper
    • , Mark E. Jenkins
    • , Noralane M. Lindor
    • , Polly A. Newcomb
    • , Steven Gallinger
    • , David Duggan
    • , Graham Casey
    • , Per Hoffmann
    • , Markus M. Nöthen
    • , Karl-Heinz Jöckel
    • , Douglas F. Easton
    • , Paul D. P. Pharoah
    • , Julian Peto
    • , Federico Canzian
    • , Anthony Swerdlow
    • , Rosalind A. Eeles
    • , Zsofia Kote-Jarai
    • , Kenneth Muir
    • , Nora Pashayan
    • , Brian E. Henderson
    • , Christopher A. Haiman
    • , Fredrick R. Schumacher
    • , Ali Amin Al Olama
    • , Sara Benlloch
    • , Sonja I. Berndt
    • , David V. Conti
    • , Fredrik Wiklund
    • , Stephen Chanock
    • , Susan Gapstur
    • , Victoria L. Stevens
    • , Catherine M. Tangen
    • , Jyotsna Batra
    • , Judith Clements
    • , Henrik Gronberg
    • , Johanna Schleutker
    • , Demetrius Albanes
    • , Alicja Wolk
    • , Catharine West
    • , Lorelei Mucci
    • , Géraldine Cancel-Tassin
    • , Stella Koutros
    • , Karina Dalsgaard Sorensen
    • , Eli Marie Grindedal
    • , David E. Neal
    • , Freddie C. Hamdy
    • , Jenny L. Donovan
    • , Ruth C. Travis
    • , Robert J. Hamilton
    • , Sue Ann Ingles
    • , Barry S. Rosenstein
    • , Yong-Jie Lu
    • , Graham G. Giles
    • , Adam S. Kibel
    • , Ana Vega
    • , Manolis Kogevinas
    • , Kathryn L. Penney
    • , Jong Y. Park
    • , Janet L. Stanford
    • , Cezary Cybulski
    • , Børge G. Nordestgaard
    • , Christiane Maier
    • , Jeri Kim
    • , Esther M. John
    • , Manuel R. Teixeira
    • , Susan L. Neuhausen
    • , Kim De Ruyck
    • , Azad Razack
    • , Lisa F. Newcomb
    • , Marija Gamulin
    • , Radka Kaneva
    • , Nawaid Usmani
    • , Frank Claessens
    • , Paul A. Townsend
    • , Manuela Gago-Dominguez
    • , Monique J. Roobol
    • , Florence Menegaux
    • , Kay-Tee Khaw
    • , Lisa Cannon-Albright
    • , Hardev Pandha
    • , Stephen N. Thibodeau
    • , Andrea Harkin
    • , Karen Allan
    • , John McQueen
    • , James Paul
    • , Timothy Iveson
    • , Mark Saunders
    • , Katja Butterbach
    • , Jenny Chang-Claude
    • , Michael Hoffmeister
    • , Hermann Brenner
    • , Iva Kirac
    • , Petar Matošević
    • , Philipp Hofer
    • , Stefanie Brezina
    • , Andrea Gsur
    • , Jeremy P. Cheadle
    • , Lauri A. Aaltonen
    • , Ian Tomlinson
    • , Richard S. Houlston
    •  & Malcolm G. Dunlop

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