Clostridium difficile articles within Nature Communications

Featured

• Article
  14 April 2021 | Open Access

  Incidence and predictive biomarkers of Clostridioides difficile infection in hospitalized patients receiving broad-spectrum antibiotics

  Here, the authors report the incidence of Clostridioides difficile infection (CDI) and assess potential clinical characteristics and biomarkers to predict CDI in 1,007 patients of 50 years and above receiving newly initiated antibiotic treatment.

  • Cornelis H. van Werkhoven
  • , Annie Ducher
  •  & Odile Launay

• Article
  02 February 2021 | Open Access

  Host immunity modulates the efficacy of microbiota transplantation for treatment of Clostridioides difficile infection

  Transfer of a host’s microbiota by faecal microbiota transplantation has shown benefit in the context of recurrent Clostridioides difficle infection. Here the authors shows the inflammatory status of the recipient can impact on engraftment and the efficacy of the introduced microbiota in a model of C.difficile infection.

  • Eric R. Littmann
  • , Jung-Jin Lee
  •  & Michael C. Abt

• Article
  20 June 2019 | Open Access

  IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection

  Here, Frisbee et al. show that hypervirulent Clostridium difficile induces IL-33 expression in the gut and IL-33 reduces mortality and morbidity via group 2 innate lymphoid cells. Furthermore, serum levels of the soluble IL-33 decoy receptor, sST2, are associated with enhanced disease severity in human C. difficile patients.

  • Alyse L. Frisbee
  • , Mahmoud M. Saleh
  •  & William A. Petri Jr.

• Article
  19 November 2018 | Open Access

  Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis

  The enterotoxins TcdA and TcdB induce cytotoxicity of epithelial cells during Clostridium difficile infection. Here the authors show that bacterial induced epithelial cell death occurs via activation of caspases 3 and 7, resulting in apoptotic cell death.

  • Pedro H. V. Saavedra
  • , Linyan Huang
  •  & Mohamed Lamkanfi

• Article
  21 August 2018 | Open Access

  A low-cost paper-based synthetic biology platform for analyzing gut microbiota and host biomarkers

  Currently, gut microbiome profiling largely relies on next-generation sequencing, which is slow and expensive. Here, the authors develop a low-cost, paper-based synthetic biology platform that allows species-specific quantification of bacterial mRNAs and clinically relevant host biomarkers.

  • Melissa K. Takahashi
  • , Xiao Tan
  •  & James J. Collins

• Article
  19 April 2016 | Open Access

  Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans

  Immunologically-active glycans are promising vaccine candidates but can be difficult to synthesize. Here, the authors show that pentavalent display of a minimal disaccharde epitope on a chemical scaffold can mimic a native C. difficileglycan antigen, representing a simple approach to synthetic vaccine production.

  • Felix Broecker
  • , Jonas Hanske
  •  & Peter H. Seeberger