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Staphylococcus aureus is a facultative pathogen that colonizes the human nares. In this Review, Peschel and colleagues discuss the mechanisms that are used by S. aureus to prevail in the human nose and the counter-strategies that are used by other commensals to interfere with its colonization.
In this Review, Stoodley and colleagues discuss current therapeutic strategies and those under development for the treatment of pathogenic biofilms. They explore novel technologies that promise to enhance the efficacy of current therapeutics or provide novel effects and argue that treating biofilm infections requires combination therapies.
This month's Genome Watch explores recent advances in the identification of species-level and strain-level diversity in microbiome studies, and highlights how these have provided insights into the tropism and persistence of Neisseria spp. in the human oral cavity.
The intestinal microbiota and its interactions with host immunity have been
intensely studied in many disease states. This knowledge could ultimately modify
clinical management of allogeneic haematopoietic stem cell transplantation,
which is accompanied by dramatic immunological and microbiota perturbations.