Class switch recombination articles from across Nature Portfolio

Class switch recombination is a process by which proliferating B cells rearrange the constant region genes in the immunoglobulin heavy chain locus to switch from expressing one class of immunoglobulin (such as IgM) to another (such as IgG). This produces an antibody with different effector properties, without altering its antigen specificity.

Latest Research and Reviews

Research
16 March 2023 | Open Access

B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation

Class switch recombination (CSR) is a process by which B cells switch their immunoglobulin isotype and develop pathogen-eliminating antibodies. Here, the authors show that a protein kinase DYRK1A is required for protection from viral infection through the regulation of CSR and effective clonal expansion.
- Liat Stoler-Barak
- , Ethan Harris
- & Ziv Shulman
Nature Communications 14, 1462
Research
28 June 2022 | Open Access

SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination

SHLD1, as a component of the Shieldin (SHLD) complex, mediates DNA repair via non-homologous end-joining (NHEJ), an essential process during lymphocyte development. Here the authors show that SHLD1 is actually dispensable for lymphocyte development and V(D)J recombination, but is essential for class-switching recombination in activated B cells.
- Estelle Vincendeau
- , Wenming Wei
- & Ludovic Deriano
Nature Communications 13, 3707
Research
27 June 2022 | Open Access

Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts

Lanzavecchia and colleagues use single-cell B cell receptor sequencing to examine the clonal structure, stability and dynamics of the B cell repertoire and the relationship between memory B cells and newly generated plasma cells in humans.
- Ganesh E. Phad
- , Dora Pinto
- & Antonio Lanzavecchia
Nature Immunology 23, 1-10
Research
21 February 2022 | Open Access

Rad52 mediates class-switch DNA recombination to IgD

IgD is expressed, predominantly together with IgM, via mRNA alternative splicing, but IgD class switch recombination (IgD CSR) has also been reported. Here the authors show, using Rad52-deficient mouse and human B cells, that IgD CSR is mediated by Rad52 through an alternative, microhomology-based end-joining pathway of DNA repair.
- Yijiang Xu
- , Hang Zhou
- & Paolo Casali
Nature Communications 13, 980
Reviews | 15 February 2022

The role of chromatin loop extrusion in antibody diversification

Alt and colleagues review recent advances in our understanding of the mechanistic role of cohesin-mediated chromatin loop extrusion in V(D)J recombination and class-switch recombination at the immunoglobulin heavy chain locus.
- Yu Zhang
- , Xuefei Zhang
- & Frederick W. Alt
Nature Reviews Immunology 22, 550-566
Research | 24 November 2021

Fam72a enforces error-prone DNA repair during antibody diversification

FAM72A interacts with UNG2 to regulate the balance between error-prone and error-free DNA repair.
- Mélanie Rogier
- , Jacques Moritz
- & Bernardo Reina-San-Martin
Nature 600, 329-333

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News and Comment

News & Views | 05 July 2022

Long-term study of the human memory B cell pool reveals high stability and recurrent plasmablasts

A single-cell sequencing study shows that the human memory B cell repertoire is dominated by large IgM, IgG2 and IgA immunoglobulin families, whereas IgG1 families, including those specific for recall antigens, are of a small size. Multi-year analysis shows that memory B cell families are highly stable and that plasmablasts of T cell–independent and T cell–dependent isotypes are produced in a recurrent manner.

Nature Immunology 23, 1002-1003
Correspondence | 16 April 2020

Interleukin 7 regulates switch transcription in developing B cells
- Audrey Dauba
- , Fatima-Zohra Braikia
- & Ahmed Amine Khamlichi
Cellular & Molecular Immunology 18, 776-778
Research Highlights | 19 August 2019

Class-switch recombination revised

Class-switch recombination was thought to take place in B cells that enter germinal centres, but this study shows that it actually occurs earlier than previously thought.
- Alexandra Flemming
Nature Reviews Immunology 19, 596-597
Correspondence | 05 August 2019

A novel regulatory region controls IgH locus transcription and switch recombination to a subset of isotypes
- Rocío Amoretti-Villa
- , Mélanie Rogier
- & Bernardo Reina-San-Martin
Cellular & Molecular Immunology 16, 887-889
Research Highlights | 26 April 2018

Shieldin the ends for 53BP1

Shieldin is a newly characterized protein complex that functions downstream of 53BP1 in promoting NHEJ
- Eytan Zlotorynski
Nature Reviews Molecular Cell Biology 19, 346-347
Research Highlights | 19 October 2016

Hypoxic germinal centers
- Ioana Visan
Nature Immunology 17, 1243

All News & Comment

Class switch recombination articles from across Nature Portfolio

Latest Research and Reviews

B cell class switch recombination is regulated by DYRK1A through MSH6 phosphorylation

SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination

Clonal structure, stability and dynamics of human memory B cells and circulating plasmablasts

Rad52 mediates class-switch DNA recombination to IgD

The role of chromatin loop extrusion in antibody diversification

Fam72a enforces error-prone DNA repair during antibody diversification

News and Comment

Long-term study of the human memory B cell pool reveals high stability and recurrent plasmablasts

Interleukin 7 regulates switch transcription in developing B cells

Class-switch recombination revised

A novel regulatory region controls IgH locus transcription and switch recombination to a subset of isotypes

Shieldin the ends for 53BP1

Hypoxic germinal centers

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