Chemistry

Definition

Chemistry is a branch of science that involves the study of the composition, structure and properties of matter. Often known as the central science, it is a creative discipline chiefly concerned with atomic and molecular structure and its change, for instance through chemical reactions.

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Latest Research and Reviews

  • Research |

    The development of selective ubiquitin-specific protease-7 (USP7) inhibitors GNE-6640 and GNE-6776, which induce tumour cell death and reveal differential kinetics of Lys-48 and Lys-63-linked ubiquitin chain depolymerization by USP7.

    • Lorna Kategaya
    • , Paola Di Lello
    • , Lionel Rougé
    • , Richard Pastor
    • , Kevin R. Clark
    • , Jason Drummond
    • , Tracy Kleinheinz
    • , Eva Lin
    • , John-Paul Upton
    • , Sumit Prakash
    • , Johanna Heideker
    • , Mark McCleland
    • , Maria Stella Ritorto
    • , Dario R. Alessi
    • , Matthias Trost
    • , Travis W. Bainbridge
    • , Michael C. M. Kwok
    • , Taylur P. Ma
    • , Zachary Stiffler
    • , Bradley Brasher
    • , Yinyan Tang
    • , Priyadarshini Jaishankar
    • , Brian R. Hearn
    • , Adam R. Renslo
    • , Michelle R. Arkin
    • , Frederick Cohen
    • , Kebing Yu
    • , Frank Peale
    • , Florian Gnad
    • , Matthew T. Chang
    • , Christiaan Klijn
    • , Elizabeth Blackwood
    • , Scott E. Martin
    • , William F. Forrest
    • , James A. Ernst
    • , Chudi Ndubaku
    • , Xiaojing Wang
    • , Maureen H. Beresini
    • , Vickie Tsui
    • , Carsten Schwerdtfeger
    • , Robert A. Blake
    • , Jeremy Murray
    • , Till Maurer
    •  & Ingrid E. Wertz
  • Research |

    Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.

    • Sheng Hui
    • , Jonathan M. Ghergurovich
    • , Raphael J. Morscher
    • , Cholsoon Jang
    • , Xin Teng
    • , Wenyun Lu
    • , Lourdes A. Esparza
    • , Tannishtha Reya
    • , Le Zhan
    • , Jessie Yanxiang Guo
    • , Eileen White
    •  & Joshua D. Rabinowitz
  • Research |

    Identification of a transmembrane protein, Mfsd2b, that is essential for the export of the signalling molecule sphingosine-1-phosphate (S1P) from red blood cells and platelets.

    • Thiet M. Vu
    • , Ayako-Nakamura Ishizu
    • , Juat Chin Foo
    • , Xiu Ru Toh
    • , Fangyu Zhang
    • , Ding Ming Whee
    • , Federico Torta
    • , Amaury Cazenave-Gassiot
    • , Takayoshi Matsumura
    • , Sangho Kim
    • , Sue-Anne E. S. Toh
    • , Toshio Suda
    • , David L. Silver
    • , Markus R. Wenk
    •  & Long N. Nguyen
  • Research |

    Small molecules are identified that inhibit the ubiquitin-specific protease USP7 with high affinity and specificity as explained by co-crystal structures, and are shown to reduce tumour growth in mice.

    • Andrew P. Turnbull
    • , Stephanos Ioannidis
    • , Wojciech W. Krajewski
    • , Adan Pinto-Fernandez
    • , Claire Heride
    • , Agnes C. L. Martin
    • , Louise M. Tonkin
    • , Elizabeth C. Townsend
    • , Shane M. Buker
    • , David R. Lancia
    • , Justin A. Caravella
    • , Angela V. Toms
    • , Thomas M. Charlton
    • , Johanna Lahdenranta
    • , Erik Wilker
    • , Bruce C. Follows
    • , Nicola J. Evans
    • , Lucy Stead
    • , Cristina Alli
    • , Vladislav V. Zarayskiy
    • , Adam C. Talbot
    • , Alexandre J. Buckmelter
    • , Minghua Wang
    • , Crystal L. McKinnon
    • , Fabienne Saab
    • , Joanna F. McGouran
    • , Hannah Century
    • , Malte Gersch
    • , Marc S. Pittman
    • , C. Gary Marshall
    • , Tony M. Raynham
    • , Mary Simcox
    • , Lorna M. D. Stewart
    • , Sheila B. McLoughlin
    • , Jaime A. Escobedo
    • , Kenneth W. Bair
    • , Christopher J. Dinsmore
    • , Tim R. Hammonds
    • , Sunkyu Kim
    • , Sylvie Urbé
    • , Michael J. Clague
    • , Benedikt M. Kessler
    •  & David Komander

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