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Checkpoint signalling blocks the cell cycle at specific transition points, checkpoints, to ensure that the events of the cell cycle take place in the correct order. Checkpoint signalling is also activated for example by damage to the DNA so that the cell cycle does not proceed until the damage is repaired.
The plant DNA damage response ensures genomic stability by controlling interconnected networks of DNA repair and cell division proteins. Decoding these networks offers potential solutions to the challenges of climate-related stress and food security.
Aberrant expression of the human hexokinase HKDC1 has been observed in patients with cancer. Here the authors report that HKDC1 expression is associated with hepatocellular carcinoma progression and PD-L1 mediated immune evasion.
This Perspective discusses recent discoveries in DNA replication initiation, specifically focusing on minichromosome maintenance protein complexes, including details on their functioning, regulatory pathways, and implications for cancer therapies.
David Barford discusses how the template model for MAD2 activation in the spindle assembly checkpoint represented a new concept for generating and propagating intracellular signals.
Proteins of the mitotic checkpoint regulate insulin receptor internalization through clathrin-mediated endocytosis, thereby modulating insulin signalling and systemic glucose metabolism.
