Chaperone-mediated autophagy articles from across Nature Portfolio

A role for ester hydrolase C11orf54 in regulating DNA damage and repair is identified. Loss of C11orf54 reduces Rad51 expression and also promotes degradation of HIF1A by chaperone-mediated autophagy leading to reduced transcription of RRM2.

Rhythmic removal of circadian clock proteins is important for the strength and periodicity of the circadian rhythm. A study now reveals that chaperone-mediated autophagy regulates the degradation of circadian proteins, and is also transcriptionally regulated by the circadian machinery. This feedback loop helps to maintain circadian oscillations.

A report suggests that leucine-rich repeat kinase 2 (LRRK2) can be degraded through chaperone-mediated autophagy (CMA) in the lysosome, and several Parkinson's disease–causing LRRK2 mutants impair CMA-mediated selective degradation of cytosolic substrates.