Cervical cancer

  • Article
    | Open Access

    Persistent infection with human papillomavirus can lead to cervical intraepithelial neoplasia (CIN). Here, the authors profile the vaginal microbiota in a cohort of non-pregnant young women diagnosed with CIN2 and find that absence of Lactobacillusspp. and presence of a diverse population of strict anaerobes associates with a decreased regression of untreated CIN2 lesions.

    • Anita Mitra
    • , David A. MacIntyre
    •  & Maria Kyrgiou
  • Article
    | Open Access

    The APOBEC mutational signature is prevalent in different tumour types. Here, using HPV16- positive cervical samples, the authors show that the signature is more prevalent in the viral genome of benign or clearing HPV16 infections compared to the viral genomes of the more advanced precancerous lesions or cervical cancer.

    • Bin Zhu
    • , Yanzi Xiao
    •  & Lisa Mirabello
  • Article
    | Open Access

    High-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and current evidences link E7 to HPV-associated carcinogenesis. Here the authors propose a model in which the infection of epithelial cells with high risk HPV results in a burst of reactive oxygen species, translocation of LDHA to the nucleus and activation of a gene profile that supports the growth of cervical cancer.

    • Yuan Liu
    • , Ji-Zheng Guo
    •  & Qun-Ying Lei
  • Article
    | Open Access

    Mutations and post-translational modifications of the PI3K/AKT pathway inhibitor PTEN are a feature of many cancers, but these have not been associated with cervical cancer. Here, the authors identify a PI3K/AKT-mediated ubiquitination degradation pathway of PTEN that occurs in patients with cervical cancer.

    • Min-Sik Lee
    • , Man-Hyung Jeong
    •  & Jaewhan Song
  • Article
    | Open Access

    The cross-talk between constitutively active EGFR- and NF-κB-dependent pathways in cancer is poorly understood. Here, the authors identify KIAA1199 as a BCL3 and NF-κB-regulated protein that is expressed in cervical lesions and promotes tumorigenesis through Plexin A2 binding and regulation of EGFR stability.

    • Kateryna Shostak
    • , Xin Zhang
    •  & Alain Chariot
  • Article
    | Open Access

    While several human papilloma virus (HPV) vaccines exist, a highly effective vaccine that mediates regression of HPV-induced tumours is lacking. Here the authors show that a therapeutic DNA vaccine-induced HPV-specific polyfunctional CD8 T cell in 7 out of 9 patients who all exhibited complete regression of lesions and viral clearance.

    • Tae Jin Kim
    • , Hyun-Tak Jin
    •  & Young Chul Sung