Centrosome articles from across Nature Portfolio

The centrosome is the major microtubule-organising centre of the cell and consists of two centrioles surrounded by pericentriolar material. The centrosome is duplicated during the cell cycle and in mitosis the two centrosomes form the poles of the mitotic spindle, which segregates the chromosomes into two daughter cells.

Latest Research and Reviews

News and Comment

  • News & Views |

    Overload of proteasomal clearance triggers formation of a large protein inclusion called the aggresome, which shares similarities with protein aggregates seen in neurodegenerative diseases such as Huntington’s. A new study uncovers how centrosome and centriolar satellite components facilitate stepwise assembly of aggresomes.

    • Elisa Vitiello
    •  & Fanni Gergely
    Nature Cell Biology 24, 408-410
  • News & Views |

    Assembly of the mitotic spindle requires timely separation of the centrosomes. Their movement apart is driven by the plus-end-directed kinesin Eg5. A new study demonstrates that the kinesin KIFC3 provides an opposing microtubule-based cohesive force that modulates centrosome separation and ensures accurate chromosome segregation.

    • Ciaran G. Morrison
    Nature Cell Biology 21, 1057-1059
  • Research Highlights |

    Two papers demonstrate that centrosome amplification can cause cancer in mammals and that a PIDDosome–p53-dependent control mechanism acts to prevent cell proliferation in the presence of extra centrosomes.

    • Anna Dart