Centrosome articles within Nature Communications

Featured

  • Article
    | Open Access

    Centrioles are characterized by an atypical triplet microtubule structure. Here, the authors discover that the ciliopathy protein HYLS1 promotes the assembly of triplet microtubules within human centrioles.

    • Yutaka Takeda
    • , Takumi Chinen
    •  & Daiju Kitagawa

  • Article
    | Open Access

    Centrioles have a conserved structure and function but have diversified in sperm. Here the authors provide insight into the molecular mechanisms and adaptive evolution underlying this diversification.

    • Sushil Khanal
    • , Ankit Jaiswal
    •  & Tomer Avidor-Reiss

  • Article
    | Open Access

    The dynein motor complex has a variety of important functions in both dividing and non-dividing cells. Here, Gallisà et al. describe a mode of regulation of dynein based on the phosphorylation of its adaptor BICD2 by the kinase PLK1, and how this is central for the regulation of centrosome position in G2 and M.

    • Núria Gallisà-Suñé
    • , Paula Sànchez-Fernàndez-de-Landa
    •  & Joan Roig

  • Article
    | Open Access

    The molecular mechanisms underpinning the organization of microtubule arrays remain unclear. Here the authors show that in human cells, the microtubule polymerase ch-TOG promotes nucleation of microtubules at the interphase centrosome and the Golgi through a mechanism that involves transient interaction with the microtubule nucleator γTuRC.

    • Aamir Ali
    • , Chithran Vineethakumari
    •  & Jens Lüders

  • Article
    | Open Access

    CEP128 is a centrosomal protein important for the organization of centriolar microtubules. Here, the authors show that a CEP128 variant observed in human male siblings causes reduced sperm counts and morphologically abnormal sperm when modeled in mice, suggesting a role for CEP128 in male fertility.

    • Xueguang Zhang
    • , Lingbo Wang
    •  & Ying Shen

  • Article
    | Open Access

    The γ-tubulin ring complex (γTuRC) nucleates microtubules at the centrosome, but how this function is related to γTuRC subcentrosomal distribution is unclear. Here the authors show that γTuRC in the centriole lumen has a nucleation-independent role in centriole integrity and cilium assembly.

    • Nina Schweizer
    • , Laurence Haren
    •  & Jens Lüders

  • Article
    | Open Access

    Centrioles are ancient organelles with a conserved architecture and their rigidity is thought to restrict microtubule sliding. Here authors show that, in mammalian sperm, the atypical distal centriole and its surrounding atypical pericentriolar matrix form a dynamic basal complex that facilitates a cascade of internal sliding deformations, coupling tail beating with asymmetric head kinking.

    • Sushil Khanal
    • , Miguel Ricardo Leung
    •  & Tomer Avidor-Reiss

  • Article
    | Open Access

    How the developing skin epidermis is transformed from a simple single-layered epithelium to a complex and stratified barrier is still an open question. Here, the authors provide a model based on high proliferation and delamination of the keratinocyte progenitors that support the stratification process.

    • Mareike Damen
    • , Lisa Wirtz
    •  & Hisham Bazzi

  • Article
    | Open Access

    Multicilia are complex, and how they achieve accurate assembly is unclear. Here, the authors show that fibrogranular materials condense into spherical cores and function in multicilia formation by tightly associating with deuterosomes and concentrating specific proteins to promote proper assembly.

    • Huijie Zhao
    • , Qingxia Chen
    •  & Xueliang Zhu

  • Article
    | Open Access

    Chromosome instability can be caused by replication stress, although the mechanism is unclear. Here, the authors show that inducing mild replication stress in cancerous and non-cancerous cell lines leads to centriole disengagement and the subsequent formation of lagging chromosomes and micronuclei.

    • Therese Wilhelm
    • , Anna-Maria Olziersky
    •  & Patrick Meraldi

  • Article
    | Open Access

    The Mitotic Exit Network (MEN) promotes mitotic exit and cytokinesis but if and how MEN independently controls these two processes is unclear. Here, the authors report that MEN displaces septins from the cell division site to promote actomyosin ring constriction, independently of MEN control of mitotic exit.

    • Davide Tamborrini
    • , Maria Angeles Juanes
    •  & Simonetta Piatti

  • Article
    | Open Access

    Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to protect centrioles against the shear stress generated by ciliary motility.

    • Alexia Mahuzier
    • , Asm Shihavuddin
    •  & Nathalie Delgehyr

  • Article
    | Open Access

    The two zygote centrioles are paternally inherited; however, their development is incompletely understood. Here, the authors show that the distal centriole is remodeled into an atypical centriole which functions as the zygote’s second centriole.

    • Emily L. Fishman
    • , Kyoung Jo
    •  & Tomer Avidor-Reiss

  • Article
    | Open Access

    Distal appendages (DAPs) at the cilia base mediate membrane docking during ciliogenesis. Here the authors use super-resolution microscopy to map 16 centriole distal end components, revealing the structure of the backbone of the DAP, as well as a previously undescribed distal appendage matrix.

    • T. Tony Yang
    • , Weng Man Chong
    •  & Jung-Chi Liao

  • Article
    | Open Access

    Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates efficient centriolar targeting of STIL, PLK4 activation and centriole assembly.

    • Yi Liu
    • , Gagan D. Gupta
    •  & Mark van Breugel

  • Article
    | Open Access

    Cancer cells are characterised by abnormalities in the number of centrosomes and this phenotype is linked with tumorigenesis. Here the authors report centriole length deregulation in a subset of cancer cell lines and suggest a link with subsequent alterations in centriole numbers and chromosomal instability.

    • Gaëlle Marteil
    • , Adan Guerrero
    •  & Mónica Bettencourt-Dias

  • Article
    | Open Access

    The spindle assembly checkpoint delays mitotic progression until sister chromatids are bi-oriented. Here the authors show that moderate delays in mitotic progression induce centrosome fragmentation and centriole disengagement and that spindle bipolarity is ensured by HSET-mediated spindle pole clustering.

    • Menuka Karki
    • , Neda Keyhaninejad
    •  & Charles B. Shuster

  • Article
    | Open Access

    Cancer cells have amplified centrosomes and deal with this abnormality by clustering them together so that they can be segregated in daughter cells. Here the authors perform a screening looking for inhibitors of this clustering process and find that STAT3 regulates this process independently of its transcriptional function.

    • Edward J. Morris
    • , Eiko Kawamura
    •  & Shoukat Dedhar

  • Article
    | Open Access

    The centriole is an organelle composed of rings of SAS-6 proteins that form a cartwheel structure. Here the authors develop a cell-free system to examine core cartwheel assembly ofC. reinhardtiiproteins and discover that CrSAS-6 has autonomous properties that facilitates self-organized stacking of pairs of rings.

    • P. Guichard
    • , V. Hamel
    •  & P. Gönczy

  • Article
    | Open Access

    The ubiquitin-proteasome system is thought to be the primary regulator of centrosome number. Here, Watanabe et al. show that selective autophagy also plays a role in regulating centrosome number via p62-dependent recruitment of centrosomal protein 63 to autophagosomes.

    • Yuichiro Watanabe
    • , Shinya Honda
    •  & Shigeomi Shimizu

  • Article
    | Open Access

    The centrosome is a large intracellular structure that serves as the microtubule-organising center, but how it is accurately assembled is not known. Here the authors generate a ‘domain-level’ centrosome interactome and show that Plk4 positions the essential centriole component Asterless by phosphorylating Cep135.

    • Brian J. Galletta
    • , Carey J. Fagerstrom
    •  & Nasser M. Rusan

  • Article
    | Open Access

    The Golgi mitotic checkpoint couples Golgi inheritance with cell cycle transition, and regulates centrosomal recruitment of the mitotic kinase Aurora-A. Here the authors show that upon Golgi ribbon fragmentation in G2, Src phosphorylates Aurora-A at the Golgi, driving its localization to the centrosomes.

    • Maria Luisa Barretta
    • , Daniela Spano
    •  & Antonino Colanzi

  • Article
    | Open Access

    Cell polarity is marked by re-orientation of the centrosome, but the mechanisms governing centrosome polarization are poorly understood. Here Obino et al. show that in lymphocytes centrosome-associated Arp2/3 nucleates actin that tethers the centrosome to the nucleus; activation depletes Arp2/3 from the centrosome and frees it from the nucleus.

    • Dorian Obino
    • , Francesca Farina
    •  & Ana-Maria Lennon-Duménil

  • Article
    | Open Access

    Centrosome amplification is common in cancer, but the mechanism is not clear. Here the authors uncover a role for Kruppel-like factor 14 (KLF14) as a transcriptional repressor of polo-like kinase 4 (PLK4); KLF14 depletion correlates with increased PLK4 in human samples and leads to centrosome amplification and tumorigenesis in mice.

    • Guangjian Fan
    • , Lianhui Sun
    •  & Chuangui Wang

  • Article
    | Open Access

    The orthogonal orientation between centrioles is thought to prevent their reduplication. Shukla et al.show that Polo-like kinase 1-dependent daughter centriole maturation, reflected in increasing inter-centriolar distance, allows centriole reduplication prior to loss of orthogonal orientation.

    • Anil Shukla
    • , Dong Kong
    •  & Jadranka Loncarek

  • Article |

    CEP63 is a centrosomal protein that is mutated in the microcephaly disease Seckel syndrome. Here the authors disrupt Cep63 in the mouse and find that neural progenitor cells undergo p53-dependent cell death, and uncover a role for CEP63 in ensuring correct meiotic recombination in male gametes.

    • Marko Marjanović
    • , Carlos Sánchez-Huertas
    •  & Travis H. Stracker

  • Article
    | Open Access

    Centrosome separation, promoted by the kinesin Eg5, is antagonized by the guanine nucleotide exchange factor Tiam1 through an unknown mechanism. Here Whalley et al. show that Tiam1 is phosphorylated by cyclin-dependent kinase 1 in prophase, leading to downstream activation of p21-activated kinases (PAKs).

    • Helen J. Whalley
    • , Andrew P. Porter
    •  & Angeliki Malliri

  • Article |

    Mutations in the deubiquitinase gene CYLD are associated with cylindromatosis, a disease characterized by the development of skin appendage tumours. Eguether et al.discover that CYLD localizes to centrosomes and is required for basal body migration and docking, providing insight into its tumour suppressor activity.

    • Thibaut Eguether
    • , Maria A. Ermolaeva
    •  & Anne-Marie Tassin

  • Article |

    Cells with multiple centrosomes, as are often observed in cancer, can still divide successfully because the centrosomes cluster to form a single spindle pole body. Drosopoulos et al.show that degradation of the kinesin Eg5 by APC/C-CDH1 is required for centrosome clustering.

    • Konstantinos Drosopoulos
    • , Chan Tang
    •  & Spiros Linardopoulos

  • Article |

    Centrosome duplication during cell division is controlled by the polo-like kinase PLK4. Nakamura et al. reveal how stress-activated protein kinase and the tumour suppressor p53 act together to regulate PLK4, and show that their combined loss in cancer cells leads to the appearance of supernumerary centrosomes.

    • Takanori Nakamura
    • , Haruo Saito
    •  & Mutsuhiro Takekawa

  • Article |

    Dysregulation of centrosome size and number is frequently associated with cancer. Fogeron et al. construct a protein-interaction network to identify proteins that are relevant for centrosome abnormalities in cancer, and show that deregulation of LGALS3BP affects centrosomal biogenesis.

    • Marie-Laure Fogeron
    • , Hannah Müller
    •  & Bodo M.H. Lange

  • Article |

    Cell division and cilium formation are dependent on centrosomes that consist of two centrioles and pericentriolar material (PCM). In this study, the Sas-4 protein is shown to be important in mediating the formation of cytoplasmic PCM complexes and the incorporation of this material into centrosomes.

    • Jayachandran Gopalakrishnan
    • , Vito Mennella
    •  & Tomer Avidor-Reiss

  • Article
    | Open Access

    Asymmetric partitioning of centrosomes has been reported inDrosophilaneuroblasts, but whether this type of division has implications for stem cell self-renewal is unclear. In this study, the authors show that the asymmetric division of the centrosomes correlates with the asymmetric fate of the cells and that the daughter centrosome is retained by the neuroblast.

    • Jens Januschke
    • , Salud Llamazares
    •  & Cayetano Gonzalez

Browse broader subjects

Browse Centrosome across other nature.com journals