Cellular neuroscience articles within Nature

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  • Article
    | Open Access

    Signalling by the developmental morphogen BMP2 through the transcription factor SMAD1 has a key role in controlling the glutamatergic innervation of parvalbumin-expressing interneurons and maintaining the balance between excitation and inhibition in the mammalian cortex.

    • Zeynep Okur
    • , Nadia Schlauri
    •  & Peter Scheiffele

  • Article
    | Open Access

    Learning results in persistent double-stranded DNA breaks, nuclear rupture and release of DNA fragments and histones within hippocampal CA1 neurons that, following TLR9-mediated DNA damage repair, results in their recruitment to memory circuits.

    • Vladimir Jovasevic
    • , Elizabeth M. Wood
    •  & Jelena Radulovic

  • Article
    | Open Access

    In response to acute thermal challenge, thermosensing glutamatergic neurons of the parabrachial nucleus in mouse brain activate tanycytes, which reduce the excitability of Flt1-expressing dopamine and agouti-related peptide-containing neurons, thus suppressing appetite.

    • Marco Benevento
    • , Alán Alpár
    •  & Tibor Harkany

  • Article
    | Open Access

    Audio and visual stimulation at 40 Hz promote cerebrospinal and interstitial fluid flux in mouse brain and result in amyloid clearance via the glymphatic system in a mouse model of Alzheimer’s disease.

    • Mitchell H. Murdock
    • , Cheng-Yi Yang
    •  & Li-Huei Tsai

  • Article
    | Open Access

    In mice, a population of astrocytes in the central striatum, characterized by expression of μ-crystallin, has a role in perseveration phenotypes that are often associated with human neuropsychiatric disorders.

    • Matthias Ollivier
    • , Joselyn S. Soto
    •  & Baljit S. Khakh

  • Article
    | Open Access

    A stream of young neurons migrating into the entorhinal cortex (EC) continues postnatally in humans, but not in macaques; these young neurons, which belong to a unique class of local circuit cells, continue to be recruited in the EC during infancy and early childhood.

    • Marcos Assis Nascimento
    • , Sean Biagiotti
    •  & Shawn F. Sorrells

  • Article
    | Open Access

     A transcriptomic cell-type atlas of the whole adult mouse brain with ~5,300 clusters built from single-cell and spatial transcriptomic datasets with more than eight million cells reveals remarkable cell type diversity across the brain and unique cell type characteristics of different brain regions. 

    • Zizhen Yao
    • , Cindy T. J. van Velthoven
    •  & Hongkui Zeng

  • Article
    | Open Access

    To construct a comprehensive atlas of cell types in each brain structure, we paired high-throughput single-nucleus RNA sequencing with Slide-seq, a recently developed spatial transcriptomics method with near-cellular resolution, across the entire mouse brain.

    • Jonah Langlieb
    • , Nina S. Sachdev
    •  & Evan Z. Macosko

  • Article |

    The authors identify a molecular switch that regulates the balance between neurotoxic and neuroprotective astrocyte populations, with potential application in the treatment of glaucoma and other optic neuropathies.

    • Evan G. Cameron
    • , Michael Nahmou
    •  & Jeffrey L. Goldberg

  • Article
    | Open Access

    Calcium-permeable GluA1 AMPA glutamate receptors are structurally and functionally distinct from the prototypical GluA2-containing AMPA receptors, impacting their role in signal transmission, synaptic plasticity and learning.

    • Danyang Zhang
    • , Josip Ivica
    •  & Ingo H. Greger

  • Article
    | Open Access

    Several independent lines of evidence demonstrated long-term potentiation induction by a structural function of calmodulin-dependent protein kinase II rather than by its enzymatic activity.

    • Jonathan E. Tullis
    • , Matthew E. Larsen
    •  & K. Ulrich Bayer

  • Article
    | Open Access

    The authors present two technologies for spatially resolved, genome-wide, joint profiling of the epigenome and transcriptome by cosequencing chromatin accessibility and gene expression, or histone modifications and gene expression on the same tissue section at near-single-cell resolution.

    • Di Zhang
    • , Yanxiang Deng
    •  & Rong Fan

  • Article
    | Open Access

    Analysis of data collected from mice learning a trace conditioning paradigm shows that phasic dopamine activity in the brain can regulate direct learning of behavioural policies, and dopamine sets an adaptive learning rate rather than an error-like teaching signal.

    • Luke T. Coddington
    • , Sarah E. Lindo
    •  & Joshua T. Dudman

  • Article |

    Synaptotagmin-3 is identified as the presynaptic high-affinity calcium sensor to rapidly replenish synaptic vesicles to maintain steady synaptic transmission.

    • Dennis J. Weingarten
    • , Amita Shrestha
    •  & Skyler L. Jackman

  • Article
    | Open Access

    Endocytosis and degradation of plasma membrane proteins in the axon initial segment, together with the diffusion-barrier mechanism, maintain a polarized distribution of plasma membrane proteins in Caenorhabditis elegans, mouse, rat and human neurons.

    • Kelsie Eichel
    • , Takeshi Uenaka
    •  & Kang Shen

  • Article |

    Experiments measuring light-evoked responses in postmortem mouse and human retinas are used to quantify decay of photoreceptors following death and optimise conditions for reviving trans-synaptic transmission.

    • Fatima Abbas
    • , Silke Becker
    •  & Frans Vinberg

  • Article |

    A chromatin accessibility atlas of 240,919 cells in the adult and developing Drosophila brain reveals 95,000 enhancers, which are integrated in cell-type specific enhancer gene regulatory networks and decoded into combinations of functional transcription factor binding sites using deep learning.

    • Jasper Janssens
    • , Sara Aibar
    •  & Stein Aerts

  • Article
    | Open Access

    Sparse labelling and whole-brain imaging are used to reconstruct and classify brain-wide complete morphologies of 1,741 individual neurons in the mouse brain, revealing a dependence on both brain region and transcriptomic profile.

    • Hanchuan Peng
    • , Peng Xie
    •  & Hongkui Zeng

  • Article
    | Open Access

    An examination of motor cortex in humans, marmosets and mice reveals a generally conserved cellular makeup that is likely to extend to many mammalian species, but also differences in gene expression, DNA methylation and chromatin state that lead to species-dependent specializations.

    • Trygve E. Bakken
    • , Nikolas L. Jorstad
    •  & Ed S. Lein

  • Article
    | Open Access

    A comprehensive survey of the epigenome from 45 regions of the mouse cortex, hippocampus, striatum, pallidum and olfactory areas using single-nucleus DNA methylation sequencing enables identification of 161 cell clusters with distinct locations and projection targets and provides insights into the regulatory landscape underlying neuronal diversity and spatial regulation.

    • Hanqing Liu
    • , Jingtian Zhou
    •  & Joseph R. Ecker

  • Article
    | Open Access

    Combined patch clamp recording, biocytin staining and single-cell RNA-sequencing of human neurocortical neurons shows an expansion of glutamatergic neuron types relative to mouse that characterizes the greater complexity of the human neocortex.

    • Jim Berg
    • , Staci A. Sorensen
    •  & Ed S. Lein

  • Article
    | Open Access

    The BRAIN Initiative Cell Census Network has constructed a multimodal cell census and atlas of the mammalian primary motor cortex in a landmark effort towards understanding brain cell-type diversity, neural circuit organization and brain function.

    • Edward M. Callaway
    • , Hong-Wei Dong
    •  & Susan Sunkin

  • Article |

    Single-nucleus transcriptomes of frontal cortex and choroid plexus samples from patients with COVID-19 reveal pathological cell states that are similar to those associated with human neurodegenerative diseases and chronic brain disorders.

    • Andrew C. Yang
    • , Fabian Kern
    •  & Tony Wyss-Coray

  • Article |

    A cell-surface fragment complementation strategy is used to identify the proteome at the junction of astrocytes and synapses in vivo, and shows that NRCAM expressed in astrocytes has a key role in regulating inhibitory synapse function.

    • Tetsuya Takano
    • , John T. Wallace
    •  & Scott H. Soderling

  • Article |

    In the thalamic reticular nucleus there are two neuron types that are segregated into central and edge zones and receive inputs from different thalamocortical nuclei, creating subcircuits with distinct dynamics.

    • Rosa I. Martinez-Garcia
    • , Bettina Voelcker
    •  & Scott J. Cruikshank

  • Article |

    Cryo-electron microscopy structures of heterodimeric and homodimeric full-length GABAB receptors, combined with cellular signalling assays, shed light on the mechanisms that underpin signal transduction mediated by these receptors.

    • Makaía M. Papasergi-Scott
    • , Michael J. Robertson
    •  & Georgios Skiniotis

  • Article |

    Acetate that is produced from the breakdown of alcohol contributes to histone acetylation in the brain, indicating that there is a direct link between alcohol metabolism and gene expression.

    • P. Mews
    • , G. Egervari
    •  & S. L. Berger

  • Article |

    RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.

    • Rebecca D. Hodge
    • , Trygve E. Bakken
    •  & Ed S. Lein

  • Letter |

    Neural blastocyst complementation creates a vacant forebrain niche in host embryos that can be populated by donor embryonic stem cell-derived dorsal telencephalic progenitors, resulting in a mouse brain organogenesis model.

    • Amelia N. Chang
    • , Zhuoyi Liang
    •  & Frederick W. Alt

  • Letter |

    Experimental evidence that global Kctd13 reduction leads to increased RhoA levels that reduce synaptic transmission, implicating RhoA as a potential therapeutic target for neuropsychiatric disorders associated with copy-number variants that include KCTD13.

    • Christine Ochoa Escamilla
    • , Irina Filonova
    •  & Craig M. Powell

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