Featured
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Article |
Membrane-anchored HDCR nanowires drive hydrogen-powered CO2 fixation
The cryo-electron microscopy structure of the filamentous hydrogen-dependent CO2 reductase (HDCR) enzyme from Thermoanaerobacter kivui, together with enzymatic analysis and in situ cryo-electron tomography, provides insight into the high catalytic activity of HDCR.
- Helge M. Dietrich
- , Ricardo D. Righetto
- & Jan M. Schuller
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Article |
Microbes exploit death-induced nutrient release by gut epithelial cells
Intestinal microorganisms exploit nutrients released by apoptotic gut epithelial cells for growth.
- Christopher J. Anderson
- , Christopher B. Medina
- & Kodi S. Ravichandran
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Article |
Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection
Upon Salmonella invasion of the mammalian cytosol, ubiquitylation of a non-proteinaceous substrate—the lipid A moiety of bacterial lipopolysaccharide—by the E3 ubiquitin ligase RNF213 marks the bacteria as cargo for antibacterial autophagy.
- Elsje G. Otten
- , Emma Werner
- & Felix Randow
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Letter |
The outer membrane is an essential load-bearing element in Gram-negative bacteria
The outer membrane of Gram-negative bacteria is shown to be at least as stiff as the cell wall, and this property enables it to protect cells from mechanical pertubations.
- Enrique R. Rojas
- , Gabriel Billings
- & Kerwyn Casey Huang
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Letter |
Ubiquitination and degradation of GBPs by a Shigella effector to suppress host defence
A Shigella flexneri type III secretion system effector targets cellular proteins for degradation via the ubiquitin/proteasome pathway, suggesting that such effectors help to overcome defences against bacterial infection.
- Peng Li
- , Wei Jiang
- & Feng Shao
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Article |
The mechanism of force transmission at bacterial focal adhesion complexes
The mystery of how bacteria that lack motile structures such as pili or flagella can ‘glide’ along surfaces is solved by a detailed description of the bacterial focal adhesion complex and its associated protein machinery.
- Laura M. Faure
- , Jean-Bernard Fiche
- & Tâm Mignot
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Article |
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
Here, a genome-wide CRISPR–Cas9 screen is used to identify the Wnt receptors frizzled as physiologically relevant Clostridium difficile toxin B receptors, providing new therapeutic targets for treating C. difficile infections.
- Liang Tao
- , Jie Zhang
- & Min Dong
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Article |
SEDS proteins are a widespread family of bacterial cell wall polymerases
SEDS proteins are core peptidoglycan polymerases involved in bacterial cell wall elongation and division.
- Alexander J. Meeske
- , Eammon P. Riley
- & David Z. Rudner
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Letter |
Growth and host interaction of mouse segmented filamentous bacteria in vitro
Development of a segmented filamentous bacteria and host cell co-culturing system that supports filamentation, segmentation, and differentiation to release viable infectious intracellular offspring.
- Pamela Schnupf
- , Valérie Gaboriau-Routhiau
- & Philippe J. Sansonetti
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Letter |
MapZ marks the division sites and positions FtsZ rings in Streptococcus pneumoniae
A new mechanism is identified for correct placement of the division machinery in Streptococcus pneumoniae that relies on the novel factor MapZ to form ring structures at the cell equator; these structures move apart as the cell elongates, acting as permanent markers of division sites.
- Aurore Fleurie
- , Christian Lesterlin
- & Christophe Grangeasse
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Letter |
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
The Pyrin inflammasome detects the presence of a pathogen not through recognition of a microbial molecule but by the activity of a bacterial toxin that modifies host Rho activity.
- Hao Xu
- , Jieling Yang
- & Feng Shao
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Letter |
Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases
Interferon-inducible GTPases are required for the release of vacuolar Gram-negative bacteria into the cytoplasm and subsequent inflammasome-mediated caspase-11 activation.
- Etienne Meunier
- , Mathias S. Dick
- & Petr Broz
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Letter |
Sequential evolution of bacterial morphology by co-option of a developmental regulator
A developmental regulator in Caulobacter evolved to specify the location of cell envelope morphogenesis in a related genus.
- Chao Jiang
- , Pamela J. B. Brown
- & Yves V. Brun
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Letter |
A type III effector antagonizes death receptor signalling during bacterial gut infection
Colonizing enteric bacteria are shown to inhibit the antimicrobial process of host cell apoptosis through the action of NleB1, a type III secretion system effector with N-acetylglucosamine transferase activity, which can bind and modify eukaryotic death-domain-containing proteins.
- Jaclyn S. Pearson
- , Cristina Giogha
- & Elizabeth L. Hartland
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Letter |
Pathogen blocks host death receptor signalling by arginine GlcNAcylation of death domains
Several death-domain-containing proteins are directly inactivated by the enteropathogenic Escherichia coli type III secretion system effector NleB; NleB functions as an N-acetylglucosamine transferase that modifies a conserved death domain arginine residue, blocking the receptor–adapter interaction.
- Shan Li
- , Li Zhang
- & Feng Shao
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Letter |
Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ
An irreversible mechanism of protein demyristoylation catalysed by invasion plasmid antigen J (IpaJ), a Shigella flexneri type III effector protein with cysteine protease activity, is described.
- Nikolay Burnaevskiy
- , Thomas G. Fox
- & Neal M. Alto
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News |
How bacteria break a magnet
A magnetosensing bacterium bends its internal magnet to weaken it before cell division.
- Ewen Callaway
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation