Cell vaccines

Cell vaccines are dead or living cells that are used to induce an immune response in the recipient, with the aim of protecting them from future disease or infection.

Latest Research and Reviews

Research
09 December 2021 | Open Access

Enhanced isolation of influenza viruses in qualified cells improves the probability of well-matched vaccines
- Heidi Peck
- , Karen L. Laurie
- & Ian G. Barr
npj Vaccines 6, 149
Research
19 July 2021 | Open Access

Ex vivo dendritic cell-based (DC) vaccine pulsed with a low dose of liposomal antigen and CpG-ODN improved PD-1 blockade immunotherapy
- Mona Yazdani
- , Zahra Gholizadeh
- & Ali Badiee
Scientific Reports 11, 14661
Research | 17 December 2020

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.
- Katie J. Ewer
- , Jordan R. Barrett
- & Elizabeth Stafford
Nature Medicine 27, 270-278
Research
14 October 2020 | Open Access

Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients

The folate receptor alpha (FRα) is overexpressed in the majority of high-grade serous ovarian cancers and has been proposed as a candidate vaccine antigen. Here the authors report the safety and immunogenicity of Th17-inducing dendritic cells pulsed with FRα-derived epitopes in an early phase I clinical trial with ovarian cancer patients.
- Matthew S. Block
- , Allan B. Dietz
- & Martin J. Cannon
Nature Communications 11, 5173
Research
16 January 2020 | Open Access

Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors
- Friedrich Erhart
- , Matthias Hackl
- & Carmen Visus
npj Vaccines 5, 5
Research
29 October 2019 | Open Access

Allogeneic dendritic cells induce potent antitumor immunity by activating KLRG1⁺CD8 T cells
- Chao Wang
- , Zhengyuan Li
- & Minghui Zhang
Scientific Reports 9, 15527

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News and Comment

Editorial | 11 June 2018

Towards advanced cell therapies

For cell therapies to transition from promises to products, increased efforts need to be put into the identification of the factors and biological mechanisms that affect safety and efficacy, and into the design of cost-effective methods for the harvesting, expansion, manipulation and purification of the cells.

Nature Biomedical Engineering 2, 339-340
Comments & Opinion | 11 June 2018

Towards superior dendritic-cell vaccines for cancer therapy

Potent dendritic-cell cancer vaccines could be used to induce functional antitumour immunity without off-target toxicity.
- Mansi Saxena
- , Sreekumar Balan
- & Nina Bhardwaj
Nature Biomedical Engineering 2, 341-346
Research Highlights | 30 May 2018

Personalized cancer vaccines hit the spot
- Megan Cully
Nature Reviews Drug Discovery 17, 393
Research Highlights | 24 April 2015

Primed for a response
- Sarah Seton-Rogers
Nature Reviews Drug Discovery 14, 312
Research Highlights | 02 April 2015

Primed for a response

The efficacy of dendritic cell vaccines can be improved in patients with glioblastoma by pre-conditioning the vaccine site with the tetanus/diphtheria toxoid.
- Sarah Seton-Rogers
Nature Reviews Cancer 15, 258-259
News | 07 January 2013

Cell-based vaccines yield only modest advances for seasonal flu
- Cassandra Willyard
Nature Medicine 19, 4

All News & Comment

Cell vaccines

Latest Research and Reviews

Enhanced isolation of influenza viruses in qualified cells improves the probability of well-matched vaccines

Ex vivo dendritic cell-based (DC) vaccine pulsed with a low dose of liposomal antigen and CpG-ODN improved PD-1 blockade immunotherapy

T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Th17-inducing autologous dendritic cell vaccination promotes antigen-specific cellular and humoral immunity in ovarian cancer patients

Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors

Allogeneic dendritic cells induce potent antitumor immunity by activating KLRG1⁺CD8 T cells

News and Comment

Towards advanced cell therapies

Towards superior dendritic-cell vaccines for cancer therapy

Personalized cancer vaccines hit the spot

Primed for a response

Primed for a response

Cell-based vaccines yield only modest advances for seasonal flu

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